Anticoagulants Prevent Monocrotaline-Induced Hepatic Parenchymal Cell Injury but Not Endothelial Cell Injury in the Rat

Monocrotaline (MCT) is a pyrrolizidine alkaloid plant toxin that produces hepatotoxicity in humans and animals. Human exposure to MCT occurs through consumption of contaminated grains and herbal medicines. Administration of MCT to rats stimulates activation of the coagulation system and fibrin depos...

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Veröffentlicht in:	Toxicology and applied pharmacology 2002-05, Vol.180 (3), p.186-196
Hauptverfasser:	Copple, Bryan L., Woolley, Brook, Banes, Amy, Ganey, Patricia E., Roth, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Anticoagulants - therapeutic use Biological and medical sciences Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology Chemical and Drug Induced Liver Injury - prevention & control coagulation endothelial cell injury Endothelium - drug effects Fibrin - metabolism fibrin deposition heparin Heparin - therapeutic use hepatotoxicity liver liver injury Male Medical sciences monocrotaline Monocrotaline - antagonists & inhibitors Monocrotaline - toxicity parenchymal cell injury Plant poisons toxicology pyrrolizidine alkaloid rat Rats Rats, Sprague-Dawley thrombin Toxicology warfarin Warfarin - therapeutic use
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