Internal hazards: baseline DNA damage by endogenous products of normal metabolism
Recent improvements in the ability to detect chemically modified bases in DNA have revealed that not only does the genetic material incur damage by foreign chemicals, but that it also sustains injury by reactive products of normal physiological processes. This review summarises current understanding...
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| Veröffentlicht in: | Mutation research 1999-07, Vol.443 (1), p.11-36 |
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| container_title | Mutation research |
| container_volume | 443 |
| creator | Burcham, Philip C |
| description | Recent improvements in the ability to detect chemically modified bases in DNA have revealed that not only does the genetic material incur damage by foreign chemicals, but that it also sustains injury by reactive products of normal physiological processes. This review summarises current understanding of the DNA-damaging potential of various substances of endogenous origin, including oxidants, lipid peroxidation products, alkylating agents, estrogens, chlorinating agents, reactive nitrogen species, and certain intermediates of various metabolic pathways. The strengths and weaknesses of the existing database for DNA damage by each class of substance are discussed, as are future strategies for resolving the difficult question of whether endogenous chemicals are significant contributors to spontaneous mutagenesis and cancer development in vivo. |
| doi_str_mv | 10.1016/S1383-5742(99)00008-3 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1383-5718 |
| ispartof | Mutation research, 1999-07, Vol.443 (1), p.11-36 |
| issn | 1383-5718 0027-5107 1879-3592 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aldehydes - chemistry Aldehydes - metabolism Alkylating Agents - chemistry Alkylating Agents - metabolism Amino Acids - metabolism Chlorine - metabolism DNA alkylation DNA Damage DNA oxidation Endogenous DNA adduct Estrogen Estrogens - metabolism Free Radicals - metabolism Heme - metabolism Humans Lipid Peroxidation Lipid Peroxides - metabolism Mutagenicity Nitrogen - metabolism |
| title | Internal hazards: baseline DNA damage by endogenous products of normal metabolism |
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