Site-Dependent Effect of O-Glycosylation on the Conformation and Biological Activity of Calcitonin

We synthesized seven O-glycosylated calcitonin derivatives, each with a single GalNAc residue attached to either Ser or Thr, and studied their three-dimensional structure and biological activity to examine site-dependent effects of O-glycosylation. The CD spectra in an aqueous trifluoroethanol solut...

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Veröffentlicht in:	Biochemistry (Easton) 2001-09, Vol.40 (37), p.11090-11095
Hauptverfasser:	Tagashira, Mizuka, Iijima, Hideki, Isogai, Yukihiro, Hori, Masayuki, Takamatsu, Shinji, Fujibayashi, Yasuhisa, Yoshizawa-Kumagaye, Kumiko, Isaka, Shuji, Nakajima, Kiichiro, Yamamoto, Toshihiro, Teshima, Tadashi, Toma, Kazunori
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylgalactosamine - chemistry Amino Acid Sequence Animals Biological Assay Calcitonin - analogs & derivatives Calcitonin - metabolism Calcitonin - pharmacology Eels Glycosylation Hypocalcemia - chemically induced Male Molecular Sequence Data Rats Rats, Sprague-Dawley Receptors, Calcitonin - metabolism Serine - analogs & derivatives Structure-Activity Relationship Threonine - analogs & derivatives
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