Inhibitory Effect of Hydroxypropyl Methylcellulose Acetate Succinate on Drug Recrystallization from a Supersaturated Solution Assessed Using Nuclear Magnetic Resonance Measurements

We examined the inhibitory effect of hydroxypropyl methylcellulose acetate succinate (HPMC-AS) on drug recrystallization from a supersaturated solution using carbamazepine (CBZ) and phenytoin (PHT) as model drugs. HPMC-AS HF grade (HF) inhibited the recrystallization of CBZ more strongly than that b...

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Veröffentlicht in:	Molecular pharmaceutics 2013-10, Vol.10 (10), p.3801-3811
Hauptverfasser:	Ueda, Keisuke, Higashi, Kenjirou, Yamamoto, Keiji, Moribe, Kunikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbamazepine - chemistry Chromatography, High Pressure Liquid Crystallization Magnetic Resonance Spectroscopy - methods Methylcellulose - analogs & derivatives Methylcellulose - chemistry Molecular Structure Phenytoin - chemistry
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