Influence of virtual intervention and blood rheology on mass transfer through thoracic aortic aneurysm

Abstract Computational fluid dynamics tools have been used to investigate blood flow through the human thoracic aortic models with aneurysm before and after virtual stent graft operation. The impact of blood rheology and aortic geometry on the wall shear stress (WSS), luminal surface low-density lip...

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Veröffentlicht in:Journal of biomechanics 2015-09, Vol.48 (12), p.3312-3322
Hauptverfasser: Lei, Yu, Chen, Ming, Xiong, Guanglei, Chen, Jie
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creator Lei, Yu
Chen, Ming
Xiong, Guanglei
Chen, Jie
description Abstract Computational fluid dynamics tools have been used to investigate blood flow through the human thoracic aortic models with aneurysm before and after virtual stent graft operation. The impact of blood rheology and aortic geometry on the wall shear stress (WSS), luminal surface low-density lipoproteins (LDL) concentration, and oxygen flux along the arterial wall is investigated. The stent graft at the aneurysm has significant effects on WSS and mass transport in blood flow. Due to the low flow rate, Newtonian blood assumption generally under-estimates the WSS. The non-Newtonian blood rheology play an important role in the LDL transport as well as oxygen transport. It is found that WSS alone is insufficient to correctly predict the location with high risk of atherogenesis. The results suggest that WSS, luminal surface LDL concentration, and the oxygen flux on the wall have to be considered together to evaluate the performance of virtual operation.
doi_str_mv 10.1016/j.jbiomech.2015.06.022
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The impact of blood rheology and aortic geometry on the wall shear stress (WSS), luminal surface low-density lipoproteins (LDL) concentration, and oxygen flux along the arterial wall is investigated. The stent graft at the aneurysm has significant effects on WSS and mass transport in blood flow. Due to the low flow rate, Newtonian blood assumption generally under-estimates the WSS. The non-Newtonian blood rheology play an important role in the LDL transport as well as oxygen transport. It is found that WSS alone is insufficient to correctly predict the location with high risk of atherogenesis. 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The impact of blood rheology and aortic geometry on the wall shear stress (WSS), luminal surface low-density lipoproteins (LDL) concentration, and oxygen flux along the arterial wall is investigated. The stent graft at the aneurysm has significant effects on WSS and mass transport in blood flow. Due to the low flow rate, Newtonian blood assumption generally under-estimates the WSS. The non-Newtonian blood rheology play an important role in the LDL transport as well as oxygen transport. It is found that WSS alone is insufficient to correctly predict the location with high risk of atherogenesis. 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subjects Aneurysm
Aneurysms
Aorta, Thoracic - physiopathology
Aortic Aneurysm, Thoracic - physiopathology
Aortic Aneurysm, Thoracic - therapy
Atherosclerosis
Atherosclerosis - physiopathology
Biomechanical Phenomena
Blood
Blood flow
Computer Simulation
Coronary vessels
Fluid dynamics
Flux
Grafting
Hemodynamics
Humans
Hydrodynamics
Hypoxia
Low-density lipoprotein
Mass transfer
Models, Biological
Non-Newtonian
Oxygen transport
Permeability
Physical Medicine and Rehabilitation
Regional Blood Flow
Reynolds number
Rheology
Shear stress
Stent graft
Stents
Studies
Surgical implants
Transport
Veins & arteries
Wall shear stress
title Influence of virtual intervention and blood rheology on mass transfer through thoracic aortic aneurysm
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