Capacities of metabotropic glutamate modulators in counteracting soman-induced seizures in rats

Current treatment of nerve agent poisoning with ionotropic drugs proves inadequate, and alternative treatment strategies are searched for. Based on positive findings with metabotropic glutamate modulators in microinfusion studies, the present study was initiated to examine anticonvulsant effects of...

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Veröffentlicht in:	European journal of pharmacology 2013-10, Vol.718 (1-3), p.253-260
Hauptverfasser:	Myhrer, Trond, Mariussen, Espen, Enger, Siri, Aas, Pål
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism agonists Animals antagonists anticonvulsants Anticonvulsants - pharmacology Anticonvulsants - therapeutic use brain Butyrylcholinesterase - metabolism Cyclopropanes - pharmacology Cyclopropanes - therapeutic use DCG-IV Drug Interactions glutamic acid Glycine - analogs & derivatives Glycine - pharmacology Glycine - therapeutic use HI-6 Levetiracetam Male MPEP nerve tissue Oximes - pharmacology Piracetam - analogs & derivatives Piracetam - pharmacology poisoning Procyclidine Procyclidine - pharmacology pyridines Pyridines - pharmacology Pyridines - therapeutic use Pyridinium Compounds - pharmacology Rats Rats, Wistar Receptor, Metabotropic Glutamate 5 - agonists Receptor, Metabotropic Glutamate 5 - antagonists & inhibitors seizures Seizures - chemically induced Seizures - drug therapy Seizures - enzymology Soman Soman - adverse effects
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