Prognostic nomogram for refining the prognostication of the proposed 8th edition of the AJCC/UICC staging system for nasopharyngeal cancer in the era of intensity‐modulated radiotherapy
BACKGROUND The objective of this study was to develop a nomogram for refining prognostication for patients with nondisseminated nasopharyngeal cancer (NPC) staged with the proposed 8th edition of the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) staging syst...
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| Veröffentlicht in: | Cancer 2016-11, Vol.122 (21), p.3307-3315 |
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| creator | Pan, Jian Ji Ng, Wai Tong Zong, Jing Feng Lee, Sarah W. M. Choi, Horace C. W. Chan, Lucy L. K. Lin, Shao Jun Guo, Qiao Juan Sze, Henry C. K. Chen, Yun Bin Xiao, You Ping Kan, Wai Kuen O'Sullivan, Brian Xu, Wei Le, Quynh Thu Glastonbury, Christine M. Colevas, A. Dimitrios Weber, Randal S. Lydiatt, William Shah, Jatin P. Lee, Anne W. M. |
| description | BACKGROUND
The objective of this study was to develop a nomogram for refining prognostication for patients with nondisseminated nasopharyngeal cancer (NPC) staged with the proposed 8th edition of the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) staging system.
METHODS
Consecutive patients who had been investigated with magnetic resonance imaging, staged with the proposed 8th edition of the AJCC/UICC staging system, and irradiated with intensity‐modulated radiotherapy from June 2005 to December 2010 were analyzed. A cohort of 1197 patients treated at Fujian Provincial Cancer Hospital was used as the training set, and the results were validated with 412 patients from Pamela Youde Nethersole Eastern Hospital. Cox regression analyses were performed to identify significant prognostic factors for developing a nomogram to predict overall survival (OS). The discriminative ability was assessed with the concordance index (c‐index). A recursive partitioning algorithm was applied to the survival scores of the combined set to categorize the patients into 3 risk groups.
RESULTS
A multivariate analysis showed that age, gross primary tumor volume, and lactate dehydrogenase were independent prognostic factors for OS in addition to the stage group. The OS nomogram based on all these factors had a statistically higher bias‐corrected c‐index than prognostication based on the stage group alone (0.712 vs 0.622, P |
| doi_str_mv | 10.1002/cncr.30198 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1837342295</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1837342295</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4648-22655b9f14bdec2ddbf154801f9eccf73ca9769467ab77a6723fd6bb305b340b3</originalsourceid><addsrcrecordid>eNqNkUtu1TAUhi1ERS-FCQtAHqJKaf1KnAyrqJSiqiBEJWaRX8k1Suxg-wpl1iV0P-yGleDbtBUjxMg69ne-I58fgDcYnWCEyKlyKpxQhJv6Gdhg1PACYUaegw1CqC5KRr8dgpcxfs8lJyV9AQ4JZ5RlZgN-fQ5-cD4mq6Dzkx-CmGDvAwymt866AaatgfMTJJL1Dvr-8Xr20WhYpy002v79dvaxbU9vLtsWxiSGvSguMZlV7kT081aExQ1GjFAJp0yA1t13miD2EuuScdGm5fft3eT1bhQpTwpCW5-pIOblFTjoxRjN64fzCNy8P__afiiuPl1ctmdXhWIVqwtCqrKUTY-Z1EYRrWWPS1Yj3DdGqZ5TJRpeNaziQnIuKk5oryspKSolZUjSI_Bu9eb__tiZmLrJRmXGUTjjd7HDNeWUEdKU_4GS7G94STJ6vKIq-Bjzurs52CnvpMOo2-fa7XPt7nPN8NsH705ORj-hj0FmAK_ATzua5R-qrr1uv6zSP12BsrA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1826729752</pqid></control><display><type>article</type><title>Prognostic nomogram for refining the prognostication of the proposed 8th edition of the AJCC/UICC staging system for nasopharyngeal cancer in the era of intensity‐modulated radiotherapy</title><source>Wiley-Blackwell Journals</source><source>MEDLINE</source><source>Wiley Online Library Free Content</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Pan, Jian Ji ; Ng, Wai Tong ; Zong, Jing Feng ; Lee, Sarah W. M. ; Choi, Horace C. W. ; Chan, Lucy L. K. ; Lin, Shao Jun ; Guo, Qiao Juan ; Sze, Henry C. K. ; Chen, Yun Bin ; Xiao, You Ping ; Kan, Wai Kuen ; O'Sullivan, Brian ; Xu, Wei ; Le, Quynh Thu ; Glastonbury, Christine M. ; Colevas, A. Dimitrios ; Weber, Randal S. ; Lydiatt, William ; Shah, Jatin P. ; Lee, Anne W. M.</creator><creatorcontrib>Pan, Jian Ji ; Ng, Wai Tong ; Zong, Jing Feng ; Lee, Sarah W. M. ; Choi, Horace C. W. ; Chan, Lucy L. K. ; Lin, Shao Jun ; Guo, Qiao Juan ; Sze, Henry C. K. ; Chen, Yun Bin ; Xiao, You Ping ; Kan, Wai Kuen ; O'Sullivan, Brian ; Xu, Wei ; Le, Quynh Thu ; Glastonbury, Christine M. ; Colevas, A. Dimitrios ; Weber, Randal S. ; Lydiatt, William ; Shah, Jatin P. ; Lee, Anne W. M.</creatorcontrib><description>BACKGROUND
The objective of this study was to develop a nomogram for refining prognostication for patients with nondisseminated nasopharyngeal cancer (NPC) staged with the proposed 8th edition of the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) staging system.
METHODS
Consecutive patients who had been investigated with magnetic resonance imaging, staged with the proposed 8th edition of the AJCC/UICC staging system, and irradiated with intensity‐modulated radiotherapy from June 2005 to December 2010 were analyzed. A cohort of 1197 patients treated at Fujian Provincial Cancer Hospital was used as the training set, and the results were validated with 412 patients from Pamela Youde Nethersole Eastern Hospital. Cox regression analyses were performed to identify significant prognostic factors for developing a nomogram to predict overall survival (OS). The discriminative ability was assessed with the concordance index (c‐index). A recursive partitioning algorithm was applied to the survival scores of the combined set to categorize the patients into 3 risk groups.
RESULTS
A multivariate analysis showed that age, gross primary tumor volume, and lactate dehydrogenase were independent prognostic factors for OS in addition to the stage group. The OS nomogram based on all these factors had a statistically higher bias‐corrected c‐index than prognostication based on the stage group alone (0.712 vs 0.622, P <.01). These results were consistent for both the training cohort and the validation cohort. Patients with <135 points were categorized as low‐risk, patients with 135 to <160 points were categorized as intermediate‐risk, and patients with ≥160 points were categorized as high‐risk. Their 5‐year OS rates were 92%, 84%, and 58%, respectively.
CONCLUSIONS
The proposed nomogram could improve prognostication in comparison with the TNM stage group. This could aid in risk stratification for individual NPC patients. Cancer 2016;122:3307–3315. © 2016 American Cancer Society.
A nomogram incorporating the TNM stage group, age, gross primary tumor volume, and lactate dehydrogenase level significantly improves prognostic power in comparison with the TNM stage group alone. More personalized treatment decisions can be achieved with this refinement of risk stratification for individual patients with nasopharyngeal cancer.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.30198</identifier><identifier>PMID: 27434142</identifier><language>eng</language><publisher>United States</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Female ; Follow-Up Studies ; Humans ; intensity‐modulated radiotherapy ; L-Lactate Dehydrogenase - metabolism ; Male ; Middle Aged ; nasopharyngeal carcinoma ; Nasopharyngeal Neoplasms - metabolism ; Nasopharyngeal Neoplasms - pathology ; Nasopharyngeal Neoplasms - radiotherapy ; Neoplasm Staging - standards ; nomogram ; Nomograms ; Prognosis ; prognostication ; Radiotherapy, Intensity-Modulated - methods ; Retrospective Studies ; Survival Rate ; TNM staging ; Young Adult</subject><ispartof>Cancer, 2016-11, Vol.122 (21), p.3307-3315</ispartof><rights>2016 American Cancer Society</rights><rights>2016 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4648-22655b9f14bdec2ddbf154801f9eccf73ca9769467ab77a6723fd6bb305b340b3</citedby><cites>FETCH-LOGICAL-c4648-22655b9f14bdec2ddbf154801f9eccf73ca9769467ab77a6723fd6bb305b340b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.30198$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.30198$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27434142$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pan, Jian Ji</creatorcontrib><creatorcontrib>Ng, Wai Tong</creatorcontrib><creatorcontrib>Zong, Jing Feng</creatorcontrib><creatorcontrib>Lee, Sarah W. M.</creatorcontrib><creatorcontrib>Choi, Horace C. W.</creatorcontrib><creatorcontrib>Chan, Lucy L. K.</creatorcontrib><creatorcontrib>Lin, Shao Jun</creatorcontrib><creatorcontrib>Guo, Qiao Juan</creatorcontrib><creatorcontrib>Sze, Henry C. K.</creatorcontrib><creatorcontrib>Chen, Yun Bin</creatorcontrib><creatorcontrib>Xiao, You Ping</creatorcontrib><creatorcontrib>Kan, Wai Kuen</creatorcontrib><creatorcontrib>O'Sullivan, Brian</creatorcontrib><creatorcontrib>Xu, Wei</creatorcontrib><creatorcontrib>Le, Quynh Thu</creatorcontrib><creatorcontrib>Glastonbury, Christine M.</creatorcontrib><creatorcontrib>Colevas, A. Dimitrios</creatorcontrib><creatorcontrib>Weber, Randal S.</creatorcontrib><creatorcontrib>Lydiatt, William</creatorcontrib><creatorcontrib>Shah, Jatin P.</creatorcontrib><creatorcontrib>Lee, Anne W. M.</creatorcontrib><title>Prognostic nomogram for refining the prognostication of the proposed 8th edition of the AJCC/UICC staging system for nasopharyngeal cancer in the era of intensity‐modulated radiotherapy</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
The objective of this study was to develop a nomogram for refining prognostication for patients with nondisseminated nasopharyngeal cancer (NPC) staged with the proposed 8th edition of the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) staging system.
METHODS
Consecutive patients who had been investigated with magnetic resonance imaging, staged with the proposed 8th edition of the AJCC/UICC staging system, and irradiated with intensity‐modulated radiotherapy from June 2005 to December 2010 were analyzed. A cohort of 1197 patients treated at Fujian Provincial Cancer Hospital was used as the training set, and the results were validated with 412 patients from Pamela Youde Nethersole Eastern Hospital. Cox regression analyses were performed to identify significant prognostic factors for developing a nomogram to predict overall survival (OS). The discriminative ability was assessed with the concordance index (c‐index). A recursive partitioning algorithm was applied to the survival scores of the combined set to categorize the patients into 3 risk groups.
RESULTS
A multivariate analysis showed that age, gross primary tumor volume, and lactate dehydrogenase were independent prognostic factors for OS in addition to the stage group. The OS nomogram based on all these factors had a statistically higher bias‐corrected c‐index than prognostication based on the stage group alone (0.712 vs 0.622, P <.01). These results were consistent for both the training cohort and the validation cohort. Patients with <135 points were categorized as low‐risk, patients with 135 to <160 points were categorized as intermediate‐risk, and patients with ≥160 points were categorized as high‐risk. Their 5‐year OS rates were 92%, 84%, and 58%, respectively.
CONCLUSIONS
The proposed nomogram could improve prognostication in comparison with the TNM stage group. This could aid in risk stratification for individual NPC patients. Cancer 2016;122:3307–3315. © 2016 American Cancer Society.
A nomogram incorporating the TNM stage group, age, gross primary tumor volume, and lactate dehydrogenase level significantly improves prognostic power in comparison with the TNM stage group alone. More personalized treatment decisions can be achieved with this refinement of risk stratification for individual patients with nasopharyngeal cancer.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Child</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>intensity‐modulated radiotherapy</subject><subject>L-Lactate Dehydrogenase - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>nasopharyngeal carcinoma</subject><subject>Nasopharyngeal Neoplasms - metabolism</subject><subject>Nasopharyngeal Neoplasms - pathology</subject><subject>Nasopharyngeal Neoplasms - radiotherapy</subject><subject>Neoplasm Staging - standards</subject><subject>nomogram</subject><subject>Nomograms</subject><subject>Prognosis</subject><subject>prognostication</subject><subject>Radiotherapy, Intensity-Modulated - methods</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>TNM staging</subject><subject>Young Adult</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtu1TAUhi1ERS-FCQtAHqJKaf1KnAyrqJSiqiBEJWaRX8k1Suxg-wpl1iV0P-yGleDbtBUjxMg69ne-I58fgDcYnWCEyKlyKpxQhJv6Gdhg1PACYUaegw1CqC5KRr8dgpcxfs8lJyV9AQ4JZ5RlZgN-fQ5-cD4mq6Dzkx-CmGDvAwymt866AaatgfMTJJL1Dvr-8Xr20WhYpy002v79dvaxbU9vLtsWxiSGvSguMZlV7kT081aExQ1GjFAJp0yA1t13miD2EuuScdGm5fft3eT1bhQpTwpCW5-pIOblFTjoxRjN64fzCNy8P__afiiuPl1ctmdXhWIVqwtCqrKUTY-Z1EYRrWWPS1Yj3DdGqZ5TJRpeNaziQnIuKk5oryspKSolZUjSI_Bu9eb__tiZmLrJRmXGUTjjd7HDNeWUEdKU_4GS7G94STJ6vKIq-Bjzurs52CnvpMOo2-fa7XPt7nPN8NsH705ORj-hj0FmAK_ATzua5R-qrr1uv6zSP12BsrA</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Pan, Jian Ji</creator><creator>Ng, Wai Tong</creator><creator>Zong, Jing Feng</creator><creator>Lee, Sarah W. M.</creator><creator>Choi, Horace C. W.</creator><creator>Chan, Lucy L. K.</creator><creator>Lin, Shao Jun</creator><creator>Guo, Qiao Juan</creator><creator>Sze, Henry C. K.</creator><creator>Chen, Yun Bin</creator><creator>Xiao, You Ping</creator><creator>Kan, Wai Kuen</creator><creator>O'Sullivan, Brian</creator><creator>Xu, Wei</creator><creator>Le, Quynh Thu</creator><creator>Glastonbury, Christine M.</creator><creator>Colevas, A. Dimitrios</creator><creator>Weber, Randal S.</creator><creator>Lydiatt, William</creator><creator>Shah, Jatin P.</creator><creator>Lee, Anne W. M.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TO</scope><scope>H94</scope></search><sort><creationdate>20161101</creationdate><title>Prognostic nomogram for refining the prognostication of the proposed 8th edition of the AJCC/UICC staging system for nasopharyngeal cancer in the era of intensity‐modulated radiotherapy</title><author>Pan, Jian Ji ; Ng, Wai Tong ; Zong, Jing Feng ; Lee, Sarah W. M. ; Choi, Horace C. W. ; Chan, Lucy L. K. ; Lin, Shao Jun ; Guo, Qiao Juan ; Sze, Henry C. K. ; Chen, Yun Bin ; Xiao, You Ping ; Kan, Wai Kuen ; O'Sullivan, Brian ; Xu, Wei ; Le, Quynh Thu ; Glastonbury, Christine M. ; Colevas, A. Dimitrios ; Weber, Randal S. ; Lydiatt, William ; Shah, Jatin P. ; Lee, Anne W. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4648-22655b9f14bdec2ddbf154801f9eccf73ca9769467ab77a6723fd6bb305b340b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Child</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>intensity‐modulated radiotherapy</topic><topic>L-Lactate Dehydrogenase - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>nasopharyngeal carcinoma</topic><topic>Nasopharyngeal Neoplasms - metabolism</topic><topic>Nasopharyngeal Neoplasms - pathology</topic><topic>Nasopharyngeal Neoplasms - radiotherapy</topic><topic>Neoplasm Staging - standards</topic><topic>nomogram</topic><topic>Nomograms</topic><topic>Prognosis</topic><topic>prognostication</topic><topic>Radiotherapy, Intensity-Modulated - methods</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>TNM staging</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pan, Jian Ji</creatorcontrib><creatorcontrib>Ng, Wai Tong</creatorcontrib><creatorcontrib>Zong, Jing Feng</creatorcontrib><creatorcontrib>Lee, Sarah W. M.</creatorcontrib><creatorcontrib>Choi, Horace C. W.</creatorcontrib><creatorcontrib>Chan, Lucy L. K.</creatorcontrib><creatorcontrib>Lin, Shao Jun</creatorcontrib><creatorcontrib>Guo, Qiao Juan</creatorcontrib><creatorcontrib>Sze, Henry C. K.</creatorcontrib><creatorcontrib>Chen, Yun Bin</creatorcontrib><creatorcontrib>Xiao, You Ping</creatorcontrib><creatorcontrib>Kan, Wai Kuen</creatorcontrib><creatorcontrib>O'Sullivan, Brian</creatorcontrib><creatorcontrib>Xu, Wei</creatorcontrib><creatorcontrib>Le, Quynh Thu</creatorcontrib><creatorcontrib>Glastonbury, Christine M.</creatorcontrib><creatorcontrib>Colevas, A. Dimitrios</creatorcontrib><creatorcontrib>Weber, Randal S.</creatorcontrib><creatorcontrib>Lydiatt, William</creatorcontrib><creatorcontrib>Shah, Jatin P.</creatorcontrib><creatorcontrib>Lee, Anne W. M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pan, Jian Ji</au><au>Ng, Wai Tong</au><au>Zong, Jing Feng</au><au>Lee, Sarah W. M.</au><au>Choi, Horace C. W.</au><au>Chan, Lucy L. K.</au><au>Lin, Shao Jun</au><au>Guo, Qiao Juan</au><au>Sze, Henry C. K.</au><au>Chen, Yun Bin</au><au>Xiao, You Ping</au><au>Kan, Wai Kuen</au><au>O'Sullivan, Brian</au><au>Xu, Wei</au><au>Le, Quynh Thu</au><au>Glastonbury, Christine M.</au><au>Colevas, A. Dimitrios</au><au>Weber, Randal S.</au><au>Lydiatt, William</au><au>Shah, Jatin P.</au><au>Lee, Anne W. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic nomogram for refining the prognostication of the proposed 8th edition of the AJCC/UICC staging system for nasopharyngeal cancer in the era of intensity‐modulated radiotherapy</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>122</volume><issue>21</issue><spage>3307</spage><epage>3315</epage><pages>3307-3315</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>BACKGROUND
The objective of this study was to develop a nomogram for refining prognostication for patients with nondisseminated nasopharyngeal cancer (NPC) staged with the proposed 8th edition of the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) staging system.
METHODS
Consecutive patients who had been investigated with magnetic resonance imaging, staged with the proposed 8th edition of the AJCC/UICC staging system, and irradiated with intensity‐modulated radiotherapy from June 2005 to December 2010 were analyzed. A cohort of 1197 patients treated at Fujian Provincial Cancer Hospital was used as the training set, and the results were validated with 412 patients from Pamela Youde Nethersole Eastern Hospital. Cox regression analyses were performed to identify significant prognostic factors for developing a nomogram to predict overall survival (OS). The discriminative ability was assessed with the concordance index (c‐index). A recursive partitioning algorithm was applied to the survival scores of the combined set to categorize the patients into 3 risk groups.
RESULTS
A multivariate analysis showed that age, gross primary tumor volume, and lactate dehydrogenase were independent prognostic factors for OS in addition to the stage group. The OS nomogram based on all these factors had a statistically higher bias‐corrected c‐index than prognostication based on the stage group alone (0.712 vs 0.622, P <.01). These results were consistent for both the training cohort and the validation cohort. Patients with <135 points were categorized as low‐risk, patients with 135 to <160 points were categorized as intermediate‐risk, and patients with ≥160 points were categorized as high‐risk. Their 5‐year OS rates were 92%, 84%, and 58%, respectively.
CONCLUSIONS
The proposed nomogram could improve prognostication in comparison with the TNM stage group. This could aid in risk stratification for individual NPC patients. Cancer 2016;122:3307–3315. © 2016 American Cancer Society.
A nomogram incorporating the TNM stage group, age, gross primary tumor volume, and lactate dehydrogenase level significantly improves prognostic power in comparison with the TNM stage group alone. More personalized treatment decisions can be achieved with this refinement of risk stratification for individual patients with nasopharyngeal cancer.</abstract><cop>United States</cop><pmid>27434142</pmid><doi>10.1002/cncr.30198</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer, 2016-11, Vol.122 (21), p.3307-3315 |
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| source | Wiley-Blackwell Journals; MEDLINE; Wiley Online Library Free Content; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Adolescent Adult Aged Aged, 80 and over Child Female Follow-Up Studies Humans intensity‐modulated radiotherapy L-Lactate Dehydrogenase - metabolism Male Middle Aged nasopharyngeal carcinoma Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - pathology Nasopharyngeal Neoplasms - radiotherapy Neoplasm Staging - standards nomogram Nomograms Prognosis prognostication Radiotherapy, Intensity-Modulated - methods Retrospective Studies Survival Rate TNM staging Young Adult |
| title | Prognostic nomogram for refining the prognostication of the proposed 8th edition of the AJCC/UICC staging system for nasopharyngeal cancer in the era of intensity‐modulated radiotherapy |
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