The Dual-specificity phosphatase Dusp15 is regulated by Sox10 and Myrf in Myelinating Oligodendrocytes

Differentiation of oligodendrocytes and myelin production in the vertebrate central nervous system require highly concerted changes in gene expression. The transcription factors Sox10 and Myrf are both central to this process and jointly regulate expression of myelin genes. Here we show that Sox10 a...

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Veröffentlicht in:	Glia 2016-12, Vol.64 (12), p.2120-2132
Hauptverfasser:	Muth, Katharina N., Piefke, Sandra, Weider, Matthias, Sock, Elisabeth, Hermans-Borgmeyer, Irm, Wegner, Michael, Küspert, Melanie
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Animals, Newborn Binding sites Brain - cytology Cell Line, Tumor Cell Proliferation - drug effects Cell Proliferation - physiology Cells, Cultured Dual-Specificity Phosphatases - genetics Dual-Specificity Phosphatases - metabolism Gene expression Gene Expression Regulation, Developmental - genetics Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Humans Mice myelin Myelin Basic Protein - genetics Myelin Basic Protein - metabolism Myelin Sheath - metabolism Myrf oligodendrocytes Oligodendroglia - metabolism Phosphatase Promoter Regions, Genetic - genetics Rats RNA, Messenger - metabolism signalling Sox10 SOXE Transcription Factors - genetics SOXE Transcription Factors - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transfection
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