Effects of radiation dose reduction in Volume Perfusion CT imaging of acute ischemic stroke
Purpose To examine the influence of radiation dose reduction on image quality and sensitivity of Volume Perfusion CT (VPCT) maps regarding the detection of ischemic brain lesions. Methods and materials VPCT data of 20 patients with suspected ischemic stroke acquired at 80 kV and 180 mAs were include...
Gespeichert in:
| Veröffentlicht in: | European radiology 2015-12, Vol.25 (12), p.3415-3422 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3422 |
|---|---|
| container_issue | 12 |
| container_start_page | 3415 |
| container_title | European radiology |
| container_volume | 25 |
| creator | Othman, Ahmed E. Brockmann, Carolin Yang, Zepa Kim, Changwon Afat, Saif Pjontek, Rastislav Nikobashman, Omid Brockmann, Marc A. Kim, Jong Hyo Wiesmann, Martin |
| description | Purpose
To examine the influence of radiation dose reduction on image quality and sensitivity of Volume Perfusion CT (VPCT) maps regarding the detection of ischemic brain lesions.
Methods and materials
VPCT data of 20 patients with suspected ischemic stroke acquired at 80 kV and 180 mAs were included. Using realistic reduced-dose simulation, low-dose VPCT datasets with 144 mAs, 108 mAs, 72 mAs and 36 mAs (80 %, 60 %, 40 % and 20 % of the original levels) were generated, resulting in a total of 100 datasets. Perfusion maps were created and signal-to-noise-ratio (SNR) measurements were performed. Qualitative analyses were conducted by two blinded readers, who also assessed the presence/absence of ischemic lesions and scored CBV and CBF maps using a modified ASPECTS-score.
Results
SNR of all low-dose datasets were significantly lower than those of the original datasets (p |
| doi_str_mv | 10.1007/s00330-015-3763-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1837341543</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1837341543</sourcerecordid><originalsourceid>FETCH-LOGICAL-c516t-be63b00b9e07512f3b2049d59f8bd300e63cd3e5556ac52ae3b4d2f34462ff4e3</originalsourceid><addsrcrecordid>eNqFkU9P3DAQxa2qVdnSfgAulaVeegmMPXYcH9GK_pGQyoFy4WAlzngbuompnRz67fGyUKFKiJM1nt97Y89j7EjAsQAwJxkAESoQukJTY2VesZVQKCsBjXrNVmCxqYy16oC9y_kGAKxQ5i07kNoCGlGv2PVZCOTnzGPgqe2Hdh7ixPuYiSfqF39fDhO_ittlJH5BKSx5d7e-5MPYboZps5O2fpmJD9n_onHwPM8p_qb37E1ot5k-PJyH7OeXs8v1t-r8x9fv69PzymtRz1VHNXYAnSUwWsiAnQRle21D0_UIUNq-R9Ja163XsiXsVF8wpWoZgiI8ZJ_3vrcp_lkoz24sL6Http0oLtmJBg0qoRW-jBoUpkFpdUE__YfexCVN5SP3lGqkklAosad8ijknCu42lb2kv06A24Xk9iG5EpLbheRM0Xx8cF66kfp_isdUCiD3QC6taUPpyehnXe8A2qCbFg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1731482420</pqid></control><display><type>article</type><title>Effects of radiation dose reduction in Volume Perfusion CT imaging of acute ischemic stroke</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Othman, Ahmed E. ; Brockmann, Carolin ; Yang, Zepa ; Kim, Changwon ; Afat, Saif ; Pjontek, Rastislav ; Nikobashman, Omid ; Brockmann, Marc A. ; Kim, Jong Hyo ; Wiesmann, Martin</creator><creatorcontrib>Othman, Ahmed E. ; Brockmann, Carolin ; Yang, Zepa ; Kim, Changwon ; Afat, Saif ; Pjontek, Rastislav ; Nikobashman, Omid ; Brockmann, Marc A. ; Kim, Jong Hyo ; Wiesmann, Martin</creatorcontrib><description>Purpose
To examine the influence of radiation dose reduction on image quality and sensitivity of Volume Perfusion CT (VPCT) maps regarding the detection of ischemic brain lesions.
Methods and materials
VPCT data of 20 patients with suspected ischemic stroke acquired at 80 kV and 180 mAs were included. Using realistic reduced-dose simulation, low-dose VPCT datasets with 144 mAs, 108 mAs, 72 mAs and 36 mAs (80 %, 60 %, 40 % and 20 % of the original levels) were generated, resulting in a total of 100 datasets. Perfusion maps were created and signal-to-noise-ratio (SNR) measurements were performed. Qualitative analyses were conducted by two blinded readers, who also assessed the presence/absence of ischemic lesions and scored CBV and CBF maps using a modified ASPECTS-score.
Results
SNR of all low-dose datasets were significantly lower than those of the original datasets (p < .05). All datasets down to 72 mAs (40 %) yielded sufficient image quality and high sensitivity with excellent inter-observer-agreements, whereas 36 mAs datasets (20 %) yielded poor image quality in 15 % of the cases with lower sensitivity and inter-observer-agreements.
Conclusion
Low-dose VPCT using decreased tube currents down to 72 mAs (40 % of original radiation dose) produces sufficient perfusion maps for the detection of ischemic brain lesions.
Key Points
•
Perfusion CT is highly accurate for the detection of ischemic brain lesions
•
Perfusion CT results in high radiation exposure, therefore low-dose protocols are required
•
Reduction of tube current down to 72 mAs produces sufficient perfusion maps</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-015-3763-7</identifier><identifier>PMID: 25903716</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Blood ; Brain - blood supply ; Brain - diagnostic imaging ; Cone-Beam Computed Tomography - methods ; Datasets ; Diagnostic Radiology ; Female ; Hospitals ; Humans ; Imaging ; Internal Medicine ; Interventional Radiology ; Ischemia ; Male ; Medical imaging ; Medicine ; Medicine & Public Health ; Neuro ; Neuroradiology ; Observer Variation ; Patients ; Radiation ; Radiation Dosage ; Radiology ; Reproducibility of Results ; Retrospective Studies ; Sensitivity and Specificity ; Signal-To-Noise Ratio ; Simulation ; Stroke ; Stroke - diagnostic imaging ; Ultrasound</subject><ispartof>European radiology, 2015-12, Vol.25 (12), p.3415-3422</ispartof><rights>European Society of Radiology 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-be63b00b9e07512f3b2049d59f8bd300e63cd3e5556ac52ae3b4d2f34462ff4e3</citedby><cites>FETCH-LOGICAL-c516t-be63b00b9e07512f3b2049d59f8bd300e63cd3e5556ac52ae3b4d2f34462ff4e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-015-3763-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-015-3763-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25903716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Othman, Ahmed E.</creatorcontrib><creatorcontrib>Brockmann, Carolin</creatorcontrib><creatorcontrib>Yang, Zepa</creatorcontrib><creatorcontrib>Kim, Changwon</creatorcontrib><creatorcontrib>Afat, Saif</creatorcontrib><creatorcontrib>Pjontek, Rastislav</creatorcontrib><creatorcontrib>Nikobashman, Omid</creatorcontrib><creatorcontrib>Brockmann, Marc A.</creatorcontrib><creatorcontrib>Kim, Jong Hyo</creatorcontrib><creatorcontrib>Wiesmann, Martin</creatorcontrib><title>Effects of radiation dose reduction in Volume Perfusion CT imaging of acute ischemic stroke</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Purpose
To examine the influence of radiation dose reduction on image quality and sensitivity of Volume Perfusion CT (VPCT) maps regarding the detection of ischemic brain lesions.
Methods and materials
VPCT data of 20 patients with suspected ischemic stroke acquired at 80 kV and 180 mAs were included. Using realistic reduced-dose simulation, low-dose VPCT datasets with 144 mAs, 108 mAs, 72 mAs and 36 mAs (80 %, 60 %, 40 % and 20 % of the original levels) were generated, resulting in a total of 100 datasets. Perfusion maps were created and signal-to-noise-ratio (SNR) measurements were performed. Qualitative analyses were conducted by two blinded readers, who also assessed the presence/absence of ischemic lesions and scored CBV and CBF maps using a modified ASPECTS-score.
Results
SNR of all low-dose datasets were significantly lower than those of the original datasets (p < .05). All datasets down to 72 mAs (40 %) yielded sufficient image quality and high sensitivity with excellent inter-observer-agreements, whereas 36 mAs datasets (20 %) yielded poor image quality in 15 % of the cases with lower sensitivity and inter-observer-agreements.
Conclusion
Low-dose VPCT using decreased tube currents down to 72 mAs (40 % of original radiation dose) produces sufficient perfusion maps for the detection of ischemic brain lesions.
Key Points
•
Perfusion CT is highly accurate for the detection of ischemic brain lesions
•
Perfusion CT results in high radiation exposure, therefore low-dose protocols are required
•
Reduction of tube current down to 72 mAs produces sufficient perfusion maps</description><subject>Aged</subject><subject>Blood</subject><subject>Brain - blood supply</subject><subject>Brain - diagnostic imaging</subject><subject>Cone-Beam Computed Tomography - methods</subject><subject>Datasets</subject><subject>Diagnostic Radiology</subject><subject>Female</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Ischemia</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuro</subject><subject>Neuroradiology</subject><subject>Observer Variation</subject><subject>Patients</subject><subject>Radiation</subject><subject>Radiation Dosage</subject><subject>Radiology</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Signal-To-Noise Ratio</subject><subject>Simulation</subject><subject>Stroke</subject><subject>Stroke - diagnostic imaging</subject><subject>Ultrasound</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU9P3DAQxa2qVdnSfgAulaVeegmMPXYcH9GK_pGQyoFy4WAlzngbuompnRz67fGyUKFKiJM1nt97Y89j7EjAsQAwJxkAESoQukJTY2VesZVQKCsBjXrNVmCxqYy16oC9y_kGAKxQ5i07kNoCGlGv2PVZCOTnzGPgqe2Hdh7ixPuYiSfqF39fDhO_ittlJH5BKSx5d7e-5MPYboZps5O2fpmJD9n_onHwPM8p_qb37E1ot5k-PJyH7OeXs8v1t-r8x9fv69PzymtRz1VHNXYAnSUwWsiAnQRle21D0_UIUNq-R9Ja163XsiXsVF8wpWoZgiI8ZJ_3vrcp_lkoz24sL6Http0oLtmJBg0qoRW-jBoUpkFpdUE__YfexCVN5SP3lGqkklAosad8ijknCu42lb2kv06A24Xk9iG5EpLbheRM0Xx8cF66kfp_isdUCiD3QC6taUPpyehnXe8A2qCbFg</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Othman, Ahmed E.</creator><creator>Brockmann, Carolin</creator><creator>Yang, Zepa</creator><creator>Kim, Changwon</creator><creator>Afat, Saif</creator><creator>Pjontek, Rastislav</creator><creator>Nikobashman, Omid</creator><creator>Brockmann, Marc A.</creator><creator>Kim, Jong Hyo</creator><creator>Wiesmann, Martin</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20151201</creationdate><title>Effects of radiation dose reduction in Volume Perfusion CT imaging of acute ischemic stroke</title><author>Othman, Ahmed E. ; Brockmann, Carolin ; Yang, Zepa ; Kim, Changwon ; Afat, Saif ; Pjontek, Rastislav ; Nikobashman, Omid ; Brockmann, Marc A. ; Kim, Jong Hyo ; Wiesmann, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-be63b00b9e07512f3b2049d59f8bd300e63cd3e5556ac52ae3b4d2f34462ff4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Blood</topic><topic>Brain - blood supply</topic><topic>Brain - diagnostic imaging</topic><topic>Cone-Beam Computed Tomography - methods</topic><topic>Datasets</topic><topic>Diagnostic Radiology</topic><topic>Female</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Ischemia</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neuro</topic><topic>Neuroradiology</topic><topic>Observer Variation</topic><topic>Patients</topic><topic>Radiation</topic><topic>Radiation Dosage</topic><topic>Radiology</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Signal-To-Noise Ratio</topic><topic>Simulation</topic><topic>Stroke</topic><topic>Stroke - diagnostic imaging</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Othman, Ahmed E.</creatorcontrib><creatorcontrib>Brockmann, Carolin</creatorcontrib><creatorcontrib>Yang, Zepa</creatorcontrib><creatorcontrib>Kim, Changwon</creatorcontrib><creatorcontrib>Afat, Saif</creatorcontrib><creatorcontrib>Pjontek, Rastislav</creatorcontrib><creatorcontrib>Nikobashman, Omid</creatorcontrib><creatorcontrib>Brockmann, Marc A.</creatorcontrib><creatorcontrib>Kim, Jong Hyo</creatorcontrib><creatorcontrib>Wiesmann, Martin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Othman, Ahmed E.</au><au>Brockmann, Carolin</au><au>Yang, Zepa</au><au>Kim, Changwon</au><au>Afat, Saif</au><au>Pjontek, Rastislav</au><au>Nikobashman, Omid</au><au>Brockmann, Marc A.</au><au>Kim, Jong Hyo</au><au>Wiesmann, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of radiation dose reduction in Volume Perfusion CT imaging of acute ischemic stroke</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>25</volume><issue>12</issue><spage>3415</spage><epage>3422</epage><pages>3415-3422</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Purpose
To examine the influence of radiation dose reduction on image quality and sensitivity of Volume Perfusion CT (VPCT) maps regarding the detection of ischemic brain lesions.
Methods and materials
VPCT data of 20 patients with suspected ischemic stroke acquired at 80 kV and 180 mAs were included. Using realistic reduced-dose simulation, low-dose VPCT datasets with 144 mAs, 108 mAs, 72 mAs and 36 mAs (80 %, 60 %, 40 % and 20 % of the original levels) were generated, resulting in a total of 100 datasets. Perfusion maps were created and signal-to-noise-ratio (SNR) measurements were performed. Qualitative analyses were conducted by two blinded readers, who also assessed the presence/absence of ischemic lesions and scored CBV and CBF maps using a modified ASPECTS-score.
Results
SNR of all low-dose datasets were significantly lower than those of the original datasets (p < .05). All datasets down to 72 mAs (40 %) yielded sufficient image quality and high sensitivity with excellent inter-observer-agreements, whereas 36 mAs datasets (20 %) yielded poor image quality in 15 % of the cases with lower sensitivity and inter-observer-agreements.
Conclusion
Low-dose VPCT using decreased tube currents down to 72 mAs (40 % of original radiation dose) produces sufficient perfusion maps for the detection of ischemic brain lesions.
Key Points
•
Perfusion CT is highly accurate for the detection of ischemic brain lesions
•
Perfusion CT results in high radiation exposure, therefore low-dose protocols are required
•
Reduction of tube current down to 72 mAs produces sufficient perfusion maps</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25903716</pmid><doi>10.1007/s00330-015-3763-7</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0938-7994 |
| ispartof | European radiology, 2015-12, Vol.25 (12), p.3415-3422 |
| issn | 0938-7994 1432-1084 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1837341543 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Aged Blood Brain - blood supply Brain - diagnostic imaging Cone-Beam Computed Tomography - methods Datasets Diagnostic Radiology Female Hospitals Humans Imaging Internal Medicine Interventional Radiology Ischemia Male Medical imaging Medicine Medicine & Public Health Neuro Neuroradiology Observer Variation Patients Radiation Radiation Dosage Radiology Reproducibility of Results Retrospective Studies Sensitivity and Specificity Signal-To-Noise Ratio Simulation Stroke Stroke - diagnostic imaging Ultrasound |
| title | Effects of radiation dose reduction in Volume Perfusion CT imaging of acute ischemic stroke |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T22%3A14%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20radiation%20dose%20reduction%20in%20Volume%20Perfusion%20CT%20imaging%20of%20acute%20ischemic%20stroke&rft.jtitle=European%20radiology&rft.au=Othman,%20Ahmed%20E.&rft.date=2015-12-01&rft.volume=25&rft.issue=12&rft.spage=3415&rft.epage=3422&rft.pages=3415-3422&rft.issn=0938-7994&rft.eissn=1432-1084&rft_id=info:doi/10.1007/s00330-015-3763-7&rft_dat=%3Cproquest_cross%3E1837341543%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1731482420&rft_id=info:pmid/25903716&rfr_iscdi=true |