Solidified Self-Nanoemulsifying Formulation for Oral Delivery of Combinatorial Therapeutic Regimen: Part II In vivo Pharmacokinetics, Antitumor Efficacy and Hepatotoxicity

Purpose The present work focuses on the in vivo evaluation of tamoxifen and quercetin combination loaded into solid self-nanoemulsifying drug delivery system (s-Tmx-QT-SNEDDS). Methods Lyophilization was employed to prepare s-Tmx-QT-SNEDDS using Aerosil 200 as carrier. The developed formulation was...

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Veröffentlicht in:	Pharmaceutical research 2014-04, Vol.31 (4), p.946-958
Hauptverfasser:	Jain, Amit K., Thanki, Kaushik, Jain, Sanyog
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - toxicity Antioxidants Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Breast cancer Chemistry, Pharmaceutical Combinatorial Chemistry Techniques - methods Drug delivery systems Drug Delivery Systems - methods Drugs Emulsifying Agents - administration & dosage Emulsifying Agents - pharmacokinetics Emulsifying Agents - toxicity Female Humans Liver - drug effects Liver - metabolism Liver - pathology MCF-7 Cells Medical Law Nanoparticles - administration & dosage Nanoparticles - metabolism Nanoparticles - toxicity Pharmaceutical sciences Pharmacology/Toxicology Pharmacy Random Allocation Rats Rats, Sprague-Dawley Research Paper Tamoxifen - administration & dosage Tamoxifen - pharmacokinetics Tamoxifen - toxicity Toxicity
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