Down-regulation of neuronal L1 cell adhesion molecule expression alleviates inflammatory neuronal injury

In multiple sclerosis (MS), the immune cell attack leads to axonal injury as a major cause for neurological disability. Here, we report a novel role of the cell adhesion molecule L1 in the crosstalk between the immune and nervous systems. L1 was found to be expressed by CNS axons of MS patients and...

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Veröffentlicht in:	Acta neuropathologica 2016-11, Vol.132 (5), p.703-720
Hauptverfasser:	Menzel, Lutz, Paterka, Magdalena, Bittner, Stefan, White, Robin, Bobkiewicz, Wiesia, van Horssen, Jack, Schachner, Melitta, Witsch, Esther, Kuhlmann, Tanja, Zipp, Frauke, Schäfer, Michael K. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Antibodies Axons - drug effects Axons - pathology Cell adhesion & migration Coculture Techniques Disease Models, Animal Down-Regulation - drug effects Down-Regulation - physiology Encephalomyelitis, Autoimmune, Experimental - chemically induced Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - pathology Female HEK293 Cells House mouse Humans Hypotheses Lymphocytes Male Medicine Medicine & Public Health Mice Mice, Inbred C57BL Mice, Transgenic Middle Aged Multiple sclerosis Myelin Proteolipid Protein - pharmacology Myelin-Oligodendrocyte Glycoprotein - pharmacology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neural Cell Adhesion Molecule L1 - genetics Neural Cell Adhesion Molecule L1 - metabolism Neurons Neurons - drug effects Neurons - metabolism Neurosciences Original Paper Pathology Peptide Fragments - pharmacology Peptides Prevention Self defense Spinal cord Synapsins - genetics Synapsins - metabolism T cells T-Lymphocytes - drug effects T-Lymphocytes - pathology T-Lymphocytes - physiology
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