Putative risk factors for postoperative pneumonia which affects poor prognosis in patients with gastric cancer
Background and objectives Several recent studies identified that postoperative infectious complications contribute to recurrence and poor outcome in patients with gastric cancer. This study was designed to investigate the prognostic impact of postoperative pneumonia, and to identify the putative ris...
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| Veröffentlicht in: | International journal of clinical oncology 2016-10, Vol.21 (5), p.920-926 |
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| container_title | International journal of clinical oncology |
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| creator | Kiuchi, Jun Komatsu, Shuhei Ichikawa, Daisuke Kosuga, Toshiyuki Okamoto, Kazuma Konishi, Hirotaka Shiozaki, Atsushi Fujiwara, Hitoshi Yasuda, Tomoyo Otsuji, Eigo |
| description | Background and objectives
Several recent studies identified that postoperative infectious complications contribute to recurrence and poor outcome in patients with gastric cancer. This study was designed to investigate the prognostic impact of postoperative pneumonia, and to identify the putative risk factors for its occurrence.
Methods
We retrospectively analyzed 1,415 consecutive patients who underwent curative gastrectomy for gastric cancer between 1997 and 2013.
Results
A total of 31 (2.2 %) patients developed postoperative pneumonia (Clavien–Dindo classification ≥II). Patients with postoperative pneumonia showed a significantly poorer prognosis than patients without (
P
|
| doi_str_mv | 10.1007/s10147-016-0987-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1837339936</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1837339936</sourcerecordid><originalsourceid>FETCH-LOGICAL-c429t-a8170915fc04643c6c27a9c5f5bfc04ae53c38dfcfa88240baecea5e206eeb453</originalsourceid><addsrcrecordid>eNqNkU1rFTEYhYMotrb-ADcScONmbL4mH0sp1QoFu7DrkJu-uTf13mRMMi3-ezNOFREEV3nJec5JXg5Cryh5RwlRZ5USKtRAqByI0WrQT9AxFVwNSin2tM9c0MFINh6hF7XeEUKVHNlzdMQUVdwIc4zS9dxci_eAS6xfcXC-5VJxyAVPubY8QVnlKcF8yCk6_LCLfoddCOBb7dSClrxNucaKY8JTN0Dq0kNsO7x1tZXosXfJQzlFz4LbV3j5eJ6gmw8XX84vh6vPHz-dv78avGCmDU5TRQwdgydCCu6lZ8oZP4Zxs1w5GLnn-jb44LRmgmwceHAjMCIBNmLkJ-jtmtt_9m2G2uwhVg_7vUuQ52qp5opzY7j8D5RJqaRipqNv_kLv8lxSX-QnpTUlSneKrpQvudYCwU4lHlz5bimxS2927c323uzSm108rx-T580Bbn87fhXVAbYCtUtpC-WPp_-Z-gOvlaTz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1826881078</pqid></control><display><type>article</type><title>Putative risk factors for postoperative pneumonia which affects poor prognosis in patients with gastric cancer</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Kiuchi, Jun ; Komatsu, Shuhei ; Ichikawa, Daisuke ; Kosuga, Toshiyuki ; Okamoto, Kazuma ; Konishi, Hirotaka ; Shiozaki, Atsushi ; Fujiwara, Hitoshi ; Yasuda, Tomoyo ; Otsuji, Eigo</creator><creatorcontrib>Kiuchi, Jun ; Komatsu, Shuhei ; Ichikawa, Daisuke ; Kosuga, Toshiyuki ; Okamoto, Kazuma ; Konishi, Hirotaka ; Shiozaki, Atsushi ; Fujiwara, Hitoshi ; Yasuda, Tomoyo ; Otsuji, Eigo</creatorcontrib><description>Background and objectives
Several recent studies identified that postoperative infectious complications contribute to recurrence and poor outcome in patients with gastric cancer. This study was designed to investigate the prognostic impact of postoperative pneumonia, and to identify the putative risk factors for its occurrence.
Methods
We retrospectively analyzed 1,415 consecutive patients who underwent curative gastrectomy for gastric cancer between 1997 and 2013.
Results
A total of 31 (2.2 %) patients developed postoperative pneumonia (Clavien–Dindo classification ≥II). Patients with postoperative pneumonia showed a significantly poorer prognosis than patients without (
P
< 0.001). Concerning the occurrence of postoperative pneumonia, univariate and multivariate analyses identified older age (≥65 years;
P
= 0.010; odds ratio [OR] 3.59), lower nutritious status (albumin <3 0;
P
= 0.029; OR 4.51), advanced stage (pStage ≥II;
P
= 0.045; OR 2.35), concurrent hypertension (
P
= 0.042; OR 2.21) and total gastrectomy (
P
= 0.026; OR 2.42) as independent risk factors.
Conclusions
Postoperative pneumonia was shown to be associated with long-term poor outcome in patients with gastric cancer. Care should be taken for patients with clinical factors such as older age, lower nutritional status, advanced stage, concurrent hypertension, and total gastrectomy.</description><identifier>ISSN: 1341-9625</identifier><identifier>EISSN: 1437-7772</identifier><identifier>DOI: 10.1007/s10147-016-0987-8</identifier><identifier>PMID: 27173949</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Age Factors ; Aged ; Cancer Research ; Female ; Gastrectomy - adverse effects ; Gastrectomy - methods ; Gastric cancer ; Humans ; Hypertension - complications ; Male ; Medical prognosis ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Staging ; Nutritional Status ; Older people ; Oncology ; Original Article ; Pneumonia ; Pneumonia - etiology ; Postoperative Complications ; Prognosis ; Retrospective Studies ; Risk Factors ; Stomach Neoplasms - complications ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Surgical Oncology ; Surgical outcomes</subject><ispartof>International journal of clinical oncology, 2016-10, Vol.21 (5), p.920-926</ispartof><rights>Japan Society of Clinical Oncology 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-a8170915fc04643c6c27a9c5f5bfc04ae53c38dfcfa88240baecea5e206eeb453</citedby><cites>FETCH-LOGICAL-c429t-a8170915fc04643c6c27a9c5f5bfc04ae53c38dfcfa88240baecea5e206eeb453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10147-016-0987-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10147-016-0987-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27173949$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kiuchi, Jun</creatorcontrib><creatorcontrib>Komatsu, Shuhei</creatorcontrib><creatorcontrib>Ichikawa, Daisuke</creatorcontrib><creatorcontrib>Kosuga, Toshiyuki</creatorcontrib><creatorcontrib>Okamoto, Kazuma</creatorcontrib><creatorcontrib>Konishi, Hirotaka</creatorcontrib><creatorcontrib>Shiozaki, Atsushi</creatorcontrib><creatorcontrib>Fujiwara, Hitoshi</creatorcontrib><creatorcontrib>Yasuda, Tomoyo</creatorcontrib><creatorcontrib>Otsuji, Eigo</creatorcontrib><title>Putative risk factors for postoperative pneumonia which affects poor prognosis in patients with gastric cancer</title><title>International journal of clinical oncology</title><addtitle>Int J Clin Oncol</addtitle><addtitle>Int J Clin Oncol</addtitle><description>Background and objectives
Several recent studies identified that postoperative infectious complications contribute to recurrence and poor outcome in patients with gastric cancer. This study was designed to investigate the prognostic impact of postoperative pneumonia, and to identify the putative risk factors for its occurrence.
Methods
We retrospectively analyzed 1,415 consecutive patients who underwent curative gastrectomy for gastric cancer between 1997 and 2013.
Results
A total of 31 (2.2 %) patients developed postoperative pneumonia (Clavien–Dindo classification ≥II). Patients with postoperative pneumonia showed a significantly poorer prognosis than patients without (
P
< 0.001). Concerning the occurrence of postoperative pneumonia, univariate and multivariate analyses identified older age (≥65 years;
P
= 0.010; odds ratio [OR] 3.59), lower nutritious status (albumin <3 0;
P
= 0.029; OR 4.51), advanced stage (pStage ≥II;
P
= 0.045; OR 2.35), concurrent hypertension (
P
= 0.042; OR 2.21) and total gastrectomy (
P
= 0.026; OR 2.42) as independent risk factors.
Conclusions
Postoperative pneumonia was shown to be associated with long-term poor outcome in patients with gastric cancer. Care should be taken for patients with clinical factors such as older age, lower nutritional status, advanced stage, concurrent hypertension, and total gastrectomy.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Cancer Research</subject><subject>Female</subject><subject>Gastrectomy - adverse effects</subject><subject>Gastrectomy - methods</subject><subject>Gastric cancer</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Nutritional Status</subject><subject>Older people</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pneumonia</subject><subject>Pneumonia - etiology</subject><subject>Postoperative Complications</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Stomach Neoplasms - complications</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>Surgical Oncology</subject><subject>Surgical outcomes</subject><issn>1341-9625</issn><issn>1437-7772</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkU1rFTEYhYMotrb-ADcScONmbL4mH0sp1QoFu7DrkJu-uTf13mRMMi3-ezNOFREEV3nJec5JXg5Cryh5RwlRZ5USKtRAqByI0WrQT9AxFVwNSin2tM9c0MFINh6hF7XeEUKVHNlzdMQUVdwIc4zS9dxci_eAS6xfcXC-5VJxyAVPubY8QVnlKcF8yCk6_LCLfoddCOBb7dSClrxNucaKY8JTN0Dq0kNsO7x1tZXosXfJQzlFz4LbV3j5eJ6gmw8XX84vh6vPHz-dv78avGCmDU5TRQwdgydCCu6lZ8oZP4Zxs1w5GLnn-jb44LRmgmwceHAjMCIBNmLkJ-jtmtt_9m2G2uwhVg_7vUuQ52qp5opzY7j8D5RJqaRipqNv_kLv8lxSX-QnpTUlSneKrpQvudYCwU4lHlz5bimxS2927c323uzSm108rx-T580Bbn87fhXVAbYCtUtpC-WPp_-Z-gOvlaTz</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Kiuchi, Jun</creator><creator>Komatsu, Shuhei</creator><creator>Ichikawa, Daisuke</creator><creator>Kosuga, Toshiyuki</creator><creator>Okamoto, Kazuma</creator><creator>Konishi, Hirotaka</creator><creator>Shiozaki, Atsushi</creator><creator>Fujiwara, Hitoshi</creator><creator>Yasuda, Tomoyo</creator><creator>Otsuji, Eigo</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20161001</creationdate><title>Putative risk factors for postoperative pneumonia which affects poor prognosis in patients with gastric cancer</title><author>Kiuchi, Jun ; Komatsu, Shuhei ; Ichikawa, Daisuke ; Kosuga, Toshiyuki ; Okamoto, Kazuma ; Konishi, Hirotaka ; Shiozaki, Atsushi ; Fujiwara, Hitoshi ; Yasuda, Tomoyo ; Otsuji, Eigo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-a8170915fc04643c6c27a9c5f5bfc04ae53c38dfcfa88240baecea5e206eeb453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Cancer Research</topic><topic>Female</topic><topic>Gastrectomy - adverse effects</topic><topic>Gastrectomy - methods</topic><topic>Gastric cancer</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Nutritional Status</topic><topic>Older people</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pneumonia</topic><topic>Pneumonia - etiology</topic><topic>Postoperative Complications</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Stomach Neoplasms - complications</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - surgery</topic><topic>Surgical Oncology</topic><topic>Surgical outcomes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kiuchi, Jun</creatorcontrib><creatorcontrib>Komatsu, Shuhei</creatorcontrib><creatorcontrib>Ichikawa, Daisuke</creatorcontrib><creatorcontrib>Kosuga, Toshiyuki</creatorcontrib><creatorcontrib>Okamoto, Kazuma</creatorcontrib><creatorcontrib>Konishi, Hirotaka</creatorcontrib><creatorcontrib>Shiozaki, Atsushi</creatorcontrib><creatorcontrib>Fujiwara, Hitoshi</creatorcontrib><creatorcontrib>Yasuda, Tomoyo</creatorcontrib><creatorcontrib>Otsuji, Eigo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kiuchi, Jun</au><au>Komatsu, Shuhei</au><au>Ichikawa, Daisuke</au><au>Kosuga, Toshiyuki</au><au>Okamoto, Kazuma</au><au>Konishi, Hirotaka</au><au>Shiozaki, Atsushi</au><au>Fujiwara, Hitoshi</au><au>Yasuda, Tomoyo</au><au>Otsuji, Eigo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Putative risk factors for postoperative pneumonia which affects poor prognosis in patients with gastric cancer</atitle><jtitle>International journal of clinical oncology</jtitle><stitle>Int J Clin Oncol</stitle><addtitle>Int J Clin Oncol</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>21</volume><issue>5</issue><spage>920</spage><epage>926</epage><pages>920-926</pages><issn>1341-9625</issn><eissn>1437-7772</eissn><abstract>Background and objectives
Several recent studies identified that postoperative infectious complications contribute to recurrence and poor outcome in patients with gastric cancer. This study was designed to investigate the prognostic impact of postoperative pneumonia, and to identify the putative risk factors for its occurrence.
Methods
We retrospectively analyzed 1,415 consecutive patients who underwent curative gastrectomy for gastric cancer between 1997 and 2013.
Results
A total of 31 (2.2 %) patients developed postoperative pneumonia (Clavien–Dindo classification ≥II). Patients with postoperative pneumonia showed a significantly poorer prognosis than patients without (
P
< 0.001). Concerning the occurrence of postoperative pneumonia, univariate and multivariate analyses identified older age (≥65 years;
P
= 0.010; odds ratio [OR] 3.59), lower nutritious status (albumin <3 0;
P
= 0.029; OR 4.51), advanced stage (pStage ≥II;
P
= 0.045; OR 2.35), concurrent hypertension (
P
= 0.042; OR 2.21) and total gastrectomy (
P
= 0.026; OR 2.42) as independent risk factors.
Conclusions
Postoperative pneumonia was shown to be associated with long-term poor outcome in patients with gastric cancer. Care should be taken for patients with clinical factors such as older age, lower nutritional status, advanced stage, concurrent hypertension, and total gastrectomy.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>27173949</pmid><doi>10.1007/s10147-016-0987-8</doi><tpages>7</tpages></addata></record> |
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| subjects | Age Factors Aged Cancer Research Female Gastrectomy - adverse effects Gastrectomy - methods Gastric cancer Humans Hypertension - complications Male Medical prognosis Medicine Medicine & Public Health Middle Aged Neoplasm Staging Nutritional Status Older people Oncology Original Article Pneumonia Pneumonia - etiology Postoperative Complications Prognosis Retrospective Studies Risk Factors Stomach Neoplasms - complications Stomach Neoplasms - pathology Stomach Neoplasms - surgery Surgical Oncology Surgical outcomes |
| title | Putative risk factors for postoperative pneumonia which affects poor prognosis in patients with gastric cancer |
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