Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western countries and is currently incurable due, in part, to difficulty in eliminating the leukemia cells protected by stromal microenvironment. Based on previous observations that CLL cells exhibit mitochondrial dysfunctio...

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Veröffentlicht in:	Oncogene 2016-10, Vol.35 (43), p.5663-5673
Hauptverfasser:	Liu, P-P, Liu, J, Jiang, W-Q, Carew, J S, Ogasawara, M A, Pelicano, H, Croce, C M, Estrov, Z, Xu, R-H, Keating, M J, Huang, P
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/31 38/77 631/67/1990/283/1895 631/67/2327 64/60 Animals Antiangina agents Antineoplastic Agents - pharmacology Apoptosis Cardiolipin Cardiolipins - metabolism Care and treatment Carnitine Carnitine O-Palmitoyltransferase - antagonists & inhibitors Carnitine O-Palmitoyltransferase - genetics Carnitine O-Palmitoyltransferase - metabolism Cell Biology Cell death Cell Line Cell Survival - drug effects Cells Chronic illnesses Chronic lymphocytic leukemia Depolarization Development and progression Diphosphatidylglycerol Disease Models, Animal Drug metabolism Drug therapy Fatty acids Gene Expression Genetic aspects Glucose - metabolism Health aspects Human Genetics Humans Internal Medicine Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Leukemia, Lymphocytic, Chronic, B-Cell - mortality Leukemia, Lymphocytic, Chronic, B-Cell - pathology Lipid metabolism Lymphatic leukemia Lymphocytes Medicine Medicine & Public Health Metabolism Mice Mice, Knockout Microenvironments Mitochondria Mitochondria - metabolism Mitochondrial Membranes - metabolism Models, Biological Oncology original-article Oxygen Consumption Patient outcomes Perhexiline - pharmacology Stromal cells Stromal Cells - drug effects Stromal Cells - metabolism Toxicity Transferases Transgenic mice Tumor Microenvironment - drug effects Xenograft Model Antitumor Assays
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