Impact of CYP2C19 Metabolizer Status on Patients With ACS Treated With Prasugrel Versus Clopidogrel

Abstract Background Certain alleles of the CYP2C19 gene are associated with higher platelet reactivity and increased ischemic events among patients treated with clopidogrel. However, the relationship of CYP2C19 genotype and outcomes in medically managed patients with acute coronary syndromes (ACS) i...

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Veröffentlicht in:	Journal of the American College of Cardiology 2016-03, Vol.67 (8), p.936-947
Hauptverfasser:	Doll, Jacob A., MD, Neely, Megan L., PhD, Roe, Matthew T., MD, MHS, Armstrong, Paul W., MD, White, Harvey D., MB, ChB, DSc, Prabhakaran, Dorairaj, MD, DM, MSc, Winters, Kenneth J., MD, Duvvuru, Suman, PhD, Sundseth, Scott S., PhD, Jakubowski, Joseph A., PhD, Gurbel, Paul A., MD, Bhatt, Deepak L., MD, MPH, Ohman, E. Magnus, MD, Fox, Keith A.A., MB, ChB
Format:	Artikel
Sprache:	eng
Schlagworte:	acute coronary syndrome Acute Coronary Syndrome - blood Acute Coronary Syndrome - drug therapy Acute Coronary Syndrome - genetics Acute coronary syndromes Aged Alleles Angina pectoris Blood platelets Cardiology Cardiovascular Cardiovascular disease Clinical outcomes Confidence intervals Coronary vessels Cytochrome P-450 CYP2C19 - genetics Cytochrome P-450 CYP2C19 - metabolism Deoxyribonucleic acid DNA DNA - genetics Dose-Response Relationship, Drug Double-Blind Method Drug dosages dual antiplatelet therapy Enzymes Female Follow-Up Studies Genetics Genotype Genotype & phenotype Heart attacks Humans Internal Medicine Male Metabolism Metabolites Middle Aged Platelet Aggregation Inhibitors - administration & dosage Platelet Function Tests platelets Polymorphism, Genetic Prasugrel Hydrochloride - administration & dosage Purinergic P2Y Receptor Antagonists - administration & dosage Retrospective Studies Stroke Ticlopidine - administration & dosage Ticlopidine - analogs & derivatives Treatment Outcome
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