Abstract 2642: Evaluation of the mechanism of MET-dependent cellular transformation and potent cytoreductive activity of MGCD265 in novel MET exon 14 mutation positive cancer models

MET splice site mutations that result in the deletion of exon 14 (METex14del) are implicated as oncogenic drivers in a subset of non-small cell lung cancer (NSCLC). MET exon 14 contains the Y1003 CBL ubiquitin ligase regulatory binding site that normally mediates CBL-dependent MET degradation and si...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2016-07, Vol.76 (14_Supplement), p.2642-2642
Hauptverfasser:	Engstrom, Lars D., Tang, Ruth W., Briere, David M., Chiang, Harrah, Olson, Peter, Christensen, James G.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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