Predictors of pathological upgrading in low-risk prostate cancer patients without hypointense lesions on an apparent diffusion coefficient map of multiparametric magnetic resonance imaging
Purpose To examine the clinicopathological features and identify the predictors of pathological upgrading in low-risk prostate cancer (PCa) patients without hypointense lesions on the apparent diffusion coefficient (ADC) map calculated from multiparametric magnetic resonance imaging. Methods We revi...
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| Veröffentlicht in: | World journal of urology 2016-11, Vol.34 (11), p.1541-1546 |
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| container_title | World journal of urology |
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| creator | Kang, Minyong Song, Byeongdo Lee, Injae Lee, Sang Eun Byun, Seok-Soo Hong, Sung Kyu |
| description | Purpose
To examine the clinicopathological features and identify the predictors of pathological upgrading in low-risk prostate cancer (PCa) patients without hypointense lesions on the apparent diffusion coefficient (ADC) map calculated from multiparametric magnetic resonance imaging.
Methods
We reviewed the medical records of 1905 PCa patients who underwent radical prostatectomy between 2007 and 2015. All ADC images were graded using the five-grade Likert scale; the positive hypointense lesions were graded 4–5. We analyzed 256 patients with low-risk classifications according to D’Amico criteria. Patients were classified into two groups according to the pathologic upgrading in the surgical specimens. The predictive factors for pathologic upgrading were evaluated using a multivariate logistic regression analysis.
Results
In 256 patients with low-risk PCa, the percentage of positive cores [odds ratio (OR) 1.09; 95 % confidence interval (CI) 1.02–1.16], the percentage of cancer in the positive cores (OR 1.07, 95 % CI 1.03–1.12), and the presence of hypointensity on an ADC map (OR 2.28; 95 % CI 1.23–4.22) were independent predictors of pathologic upgrading. Notably, 138 of low-risk patients (53.9 %) had no hypointense lesions on an ADC map. Of these 138 patients, the percentage of positive cores (OR 1.09; 95 % CI 1.01–1.18) and the percentage of cancer in the positive cores (OR 1.06; 95 % CI 1.01–1.12) remained independent predictors of pathologic upgrading.
Conclusions
In low-risk PCa patients without hypointense lesions on an ADC map, biopsy-related parameters such as the percentage of positive cores and the percentage of cancer in the positive cores were independent predictors of pathological upgrading following radical prostatectomy. |
| doi_str_mv | 10.1007/s00345-016-1829-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1837332577</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4213590131</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-1cc51f276506df2cfc48b186281179e07588494ac1f170d781b40f70d88fcbfb3</originalsourceid><addsrcrecordid>eNqNklFr1jAUhoMo7tv0B3gjAW-8qSZp2qSXMqYOBnqh1yVNT7rMNqlJyth-mz_OU74pIgiGQMLJ8745JzmEvODsDWdMvc2M1bKpGG8rrkVX3T8iBy7rutJKtI_JgSkhK9np-oSc5nzDGFcta56SE6GYkl2tDuTH5wSjtyWmTKOjqynXcY6Tt2am2zolM_owUR_oHG-r5PM3uqaYiylArQkW0i7xEEqmtx61W6HXd2v0oUDIQGfIPga0DtTgXFeTkKWjd27bT6iN4Jy3uwNdzLrnsGxz8QiaBUryFsNTgIKbBDmG_VLqMYZ5PSNPnJkzPH9Yz8jX9xdfzj9WV58-XJ6_u6qsZE2puLUNd0K1DWtHJ6yzUg9ct0JzrjpgqtFadtJY7rhio9J8kMzhTmtnBzfUZ-T10Rdr_75BLv3is4V5NgHilnuua1XXolHqP1DR4uCaIfrqL_QmbilgITulhVRtuxvyI2Xx3XMC168Jy093PWf93gX9sQt67IJd1_X3qHn54LwNC4y_Fb--HQFxBDIehQnSH1f_0_UnymHCdw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1828247667</pqid></control><display><type>article</type><title>Predictors of pathological upgrading in low-risk prostate cancer patients without hypointense lesions on an apparent diffusion coefficient map of multiparametric magnetic resonance imaging</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Kang, Minyong ; Song, Byeongdo ; Lee, Injae ; Lee, Sang Eun ; Byun, Seok-Soo ; Hong, Sung Kyu</creator><creatorcontrib>Kang, Minyong ; Song, Byeongdo ; Lee, Injae ; Lee, Sang Eun ; Byun, Seok-Soo ; Hong, Sung Kyu</creatorcontrib><description>Purpose
To examine the clinicopathological features and identify the predictors of pathological upgrading in low-risk prostate cancer (PCa) patients without hypointense lesions on the apparent diffusion coefficient (ADC) map calculated from multiparametric magnetic resonance imaging.
Methods
We reviewed the medical records of 1905 PCa patients who underwent radical prostatectomy between 2007 and 2015. All ADC images were graded using the five-grade Likert scale; the positive hypointense lesions were graded 4–5. We analyzed 256 patients with low-risk classifications according to D’Amico criteria. Patients were classified into two groups according to the pathologic upgrading in the surgical specimens. The predictive factors for pathologic upgrading were evaluated using a multivariate logistic regression analysis.
Results
In 256 patients with low-risk PCa, the percentage of positive cores [odds ratio (OR) 1.09; 95 % confidence interval (CI) 1.02–1.16], the percentage of cancer in the positive cores (OR 1.07, 95 % CI 1.03–1.12), and the presence of hypointensity on an ADC map (OR 2.28; 95 % CI 1.23–4.22) were independent predictors of pathologic upgrading. Notably, 138 of low-risk patients (53.9 %) had no hypointense lesions on an ADC map. Of these 138 patients, the percentage of positive cores (OR 1.09; 95 % CI 1.01–1.18) and the percentage of cancer in the positive cores (OR 1.06; 95 % CI 1.01–1.12) remained independent predictors of pathologic upgrading.
Conclusions
In low-risk PCa patients without hypointense lesions on an ADC map, biopsy-related parameters such as the percentage of positive cores and the percentage of cancer in the positive cores were independent predictors of pathological upgrading following radical prostatectomy.</description><identifier>ISSN: 0724-4983</identifier><identifier>EISSN: 1433-8726</identifier><identifier>DOI: 10.1007/s00345-016-1829-z</identifier><identifier>PMID: 27074937</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging - methods ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Grading - methods ; Nephrology ; Odds Ratio ; Oncology ; Original Article ; Predictive Value of Tests ; Prostate - diagnostic imaging ; Prostatic Neoplasms - diagnosis ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Urology</subject><ispartof>World journal of urology, 2016-11, Vol.34 (11), p.1541-1546</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-1cc51f276506df2cfc48b186281179e07588494ac1f170d781b40f70d88fcbfb3</citedby><cites>FETCH-LOGICAL-c405t-1cc51f276506df2cfc48b186281179e07588494ac1f170d781b40f70d88fcbfb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00345-016-1829-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00345-016-1829-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27074937$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Minyong</creatorcontrib><creatorcontrib>Song, Byeongdo</creatorcontrib><creatorcontrib>Lee, Injae</creatorcontrib><creatorcontrib>Lee, Sang Eun</creatorcontrib><creatorcontrib>Byun, Seok-Soo</creatorcontrib><creatorcontrib>Hong, Sung Kyu</creatorcontrib><title>Predictors of pathological upgrading in low-risk prostate cancer patients without hypointense lesions on an apparent diffusion coefficient map of multiparametric magnetic resonance imaging</title><title>World journal of urology</title><addtitle>World J Urol</addtitle><addtitle>World J Urol</addtitle><description>Purpose
To examine the clinicopathological features and identify the predictors of pathological upgrading in low-risk prostate cancer (PCa) patients without hypointense lesions on the apparent diffusion coefficient (ADC) map calculated from multiparametric magnetic resonance imaging.
Methods
We reviewed the medical records of 1905 PCa patients who underwent radical prostatectomy between 2007 and 2015. All ADC images were graded using the five-grade Likert scale; the positive hypointense lesions were graded 4–5. We analyzed 256 patients with low-risk classifications according to D’Amico criteria. Patients were classified into two groups according to the pathologic upgrading in the surgical specimens. The predictive factors for pathologic upgrading were evaluated using a multivariate logistic regression analysis.
Results
In 256 patients with low-risk PCa, the percentage of positive cores [odds ratio (OR) 1.09; 95 % confidence interval (CI) 1.02–1.16], the percentage of cancer in the positive cores (OR 1.07, 95 % CI 1.03–1.12), and the presence of hypointensity on an ADC map (OR 2.28; 95 % CI 1.23–4.22) were independent predictors of pathologic upgrading. Notably, 138 of low-risk patients (53.9 %) had no hypointense lesions on an ADC map. Of these 138 patients, the percentage of positive cores (OR 1.09; 95 % CI 1.01–1.18) and the percentage of cancer in the positive cores (OR 1.06; 95 % CI 1.01–1.12) remained independent predictors of pathologic upgrading.
Conclusions
In low-risk PCa patients without hypointense lesions on an ADC map, biopsy-related parameters such as the percentage of positive cores and the percentage of cancer in the positive cores were independent predictors of pathological upgrading following radical prostatectomy.</description><subject>Aged</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Grading - methods</subject><subject>Nephrology</subject><subject>Odds Ratio</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Predictive Value of Tests</subject><subject>Prostate - diagnostic imaging</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Urology</subject><issn>0724-4983</issn><issn>1433-8726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNklFr1jAUhoMo7tv0B3gjAW-8qSZp2qSXMqYOBnqh1yVNT7rMNqlJyth-mz_OU74pIgiGQMLJ8745JzmEvODsDWdMvc2M1bKpGG8rrkVX3T8iBy7rutJKtI_JgSkhK9np-oSc5nzDGFcta56SE6GYkl2tDuTH5wSjtyWmTKOjqynXcY6Tt2am2zolM_owUR_oHG-r5PM3uqaYiylArQkW0i7xEEqmtx61W6HXd2v0oUDIQGfIPga0DtTgXFeTkKWjd27bT6iN4Jy3uwNdzLrnsGxz8QiaBUryFsNTgIKbBDmG_VLqMYZ5PSNPnJkzPH9Yz8jX9xdfzj9WV58-XJ6_u6qsZE2puLUNd0K1DWtHJ6yzUg9ct0JzrjpgqtFadtJY7rhio9J8kMzhTmtnBzfUZ-T10Rdr_75BLv3is4V5NgHilnuua1XXolHqP1DR4uCaIfrqL_QmbilgITulhVRtuxvyI2Xx3XMC168Jy093PWf93gX9sQt67IJd1_X3qHn54LwNC4y_Fb--HQFxBDIehQnSH1f_0_UnymHCdw</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Kang, Minyong</creator><creator>Song, Byeongdo</creator><creator>Lee, Injae</creator><creator>Lee, Sang Eun</creator><creator>Byun, Seok-Soo</creator><creator>Hong, Sung Kyu</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20161101</creationdate><title>Predictors of pathological upgrading in low-risk prostate cancer patients without hypointense lesions on an apparent diffusion coefficient map of multiparametric magnetic resonance imaging</title><author>Kang, Minyong ; Song, Byeongdo ; Lee, Injae ; Lee, Sang Eun ; Byun, Seok-Soo ; Hong, Sung Kyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-1cc51f276506df2cfc48b186281179e07588494ac1f170d781b40f70d88fcbfb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Grading - methods</topic><topic>Nephrology</topic><topic>Odds Ratio</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Predictive Value of Tests</topic><topic>Prostate - diagnostic imaging</topic><topic>Prostatic Neoplasms - diagnosis</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Minyong</creatorcontrib><creatorcontrib>Song, Byeongdo</creatorcontrib><creatorcontrib>Lee, Injae</creatorcontrib><creatorcontrib>Lee, Sang Eun</creatorcontrib><creatorcontrib>Byun, Seok-Soo</creatorcontrib><creatorcontrib>Hong, Sung Kyu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Minyong</au><au>Song, Byeongdo</au><au>Lee, Injae</au><au>Lee, Sang Eun</au><au>Byun, Seok-Soo</au><au>Hong, Sung Kyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of pathological upgrading in low-risk prostate cancer patients without hypointense lesions on an apparent diffusion coefficient map of multiparametric magnetic resonance imaging</atitle><jtitle>World journal of urology</jtitle><stitle>World J Urol</stitle><addtitle>World J Urol</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>34</volume><issue>11</issue><spage>1541</spage><epage>1546</epage><pages>1541-1546</pages><issn>0724-4983</issn><eissn>1433-8726</eissn><abstract>Purpose
To examine the clinicopathological features and identify the predictors of pathological upgrading in low-risk prostate cancer (PCa) patients without hypointense lesions on the apparent diffusion coefficient (ADC) map calculated from multiparametric magnetic resonance imaging.
Methods
We reviewed the medical records of 1905 PCa patients who underwent radical prostatectomy between 2007 and 2015. All ADC images were graded using the five-grade Likert scale; the positive hypointense lesions were graded 4–5. We analyzed 256 patients with low-risk classifications according to D’Amico criteria. Patients were classified into two groups according to the pathologic upgrading in the surgical specimens. The predictive factors for pathologic upgrading were evaluated using a multivariate logistic regression analysis.
Results
In 256 patients with low-risk PCa, the percentage of positive cores [odds ratio (OR) 1.09; 95 % confidence interval (CI) 1.02–1.16], the percentage of cancer in the positive cores (OR 1.07, 95 % CI 1.03–1.12), and the presence of hypointensity on an ADC map (OR 2.28; 95 % CI 1.23–4.22) were independent predictors of pathologic upgrading. Notably, 138 of low-risk patients (53.9 %) had no hypointense lesions on an ADC map. Of these 138 patients, the percentage of positive cores (OR 1.09; 95 % CI 1.01–1.18) and the percentage of cancer in the positive cores (OR 1.06; 95 % CI 1.01–1.12) remained independent predictors of pathologic upgrading.
Conclusions
In low-risk PCa patients without hypointense lesions on an ADC map, biopsy-related parameters such as the percentage of positive cores and the percentage of cancer in the positive cores were independent predictors of pathological upgrading following radical prostatectomy.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27074937</pmid><doi>10.1007/s00345-016-1829-z</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Aged Follow-Up Studies Humans Magnetic Resonance Imaging - methods Male Medicine Medicine & Public Health Middle Aged Neoplasm Grading - methods Nephrology Odds Ratio Oncology Original Article Predictive Value of Tests Prostate - diagnostic imaging Prostatic Neoplasms - diagnosis Retrospective Studies Risk Assessment Risk Factors Urology |
| title | Predictors of pathological upgrading in low-risk prostate cancer patients without hypointense lesions on an apparent diffusion coefficient map of multiparametric magnetic resonance imaging |
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