Effects of NSAIDs on the osteogenic differentiation of human adipose tissue-derived stromal cells

Objectives Non‐steroidal anti‐inflammatory drugs (NSAIDs), used in the treatment of musculoskeletal pathologies, have been associated with impaired bone healing, possibly through inhibition of osteogenic differentiation. The adipose tissue (AT) is regarded as an attractive source of stromal cells fo...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2016-11, Vol.68 (11), p.1403-1408
Hauptverfasser:	Hadjicharalambous, Chrystalleni, Alexaki, Vasileia Ismini, Alpantaki, Kalliopi, Chatzinikolaidou, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - cytology adipose tissue-derived stromal cells Alkaline Phosphatase - metabolism Anti-Inflammatory Agents, Non-Steroidal - pharmacology Calcification, Physiologic - drug effects Calcium - metabolism Cell Differentiation - drug effects Cell Proliferation - drug effects Cells, Cultured Cyclooxygenase 1 - metabolism Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - pharmacology Dose-Response Relationship, Drug Gene expression Gene Expression Regulation Humans NSAIDs Osteogenesis - drug effects osteogenic differentiation Phosphatase Stromal Cells - drug effects Stromal Cells - metabolism
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