Acute Administration of Diazepam Provokes Redox Homeostasis Imbalance in the Rat Brain: Prevention by Simvastatin

ABSTRACT We investigated the effects of acute diazepam (DZP) administration on thiobarbituric acid‐reactive substance (TBARS) levels, protein carbonyl content, and on the activities of the antioxidant enzymes catalase, glutathione peroxidase, and superoxide dismutase in the brain of rats. Additional...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2016-10, Vol.30 (10), p.506-512
Hauptverfasser:	Eger, Guilherme André, Ferreira, Vinícius Vialle, Batista, Camila Ribeiro, Bonde, Henrique LuisPetrek, de Lima, Daniela Delwing, Rodrigues, André Felipe, da Cruz, José Geraldo Pereira, Magro, Débora Delwing Dal
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Anticholesteremic Agents - pharmacology Antioxidant Enzymes Brain Brain - drug effects Brain - metabolism Catalase - metabolism Diazepam Diazepam - adverse effects Diazepam - antagonists & inhibitors Drug Administration Schedule Glutathione Peroxidase - metabolism Hypnotics and Sedatives - adverse effects Hypnotics and Sedatives - antagonists & inhibitors Injections, Intraperitoneal Lipid Peroxidation Lipid Peroxidation - drug effects Oxidation-Reduction Oxidative stress Oxidative Stress - drug effects Protein Carbonylation - drug effects Rats Rats, Wistar Rodents Simvastatin Simvastatin - pharmacology Superoxide Dismutase - metabolism Thiobarbituric Acid Reactive Substances - metabolism
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