Molecular mechanisms in lithium-associated renal disease: a systematic review
Purpose Lithium is an essential treatment in bipolar disorder and treatment-resistant depression; however, its use has been limited by concerns regarding its renal adverse effects. An improved understanding of potential molecular mechanisms can help develop prevention and treatment strategies for li...
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| Veröffentlicht in: | International Urology and Nephrology 2016-11, Vol.48 (11), p.1843-1853 |
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| container_title | International Urology and Nephrology |
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| creator | Rej, Soham Pira, Shamira Marshe, Victoria Do, André Elie, Dominique Looper, Karl J. Herrmann, Nathan Müller, Daniel J. |
| description | Purpose
Lithium is an essential treatment in bipolar disorder and treatment-resistant depression; however, its use has been limited by concerns regarding its renal adverse effects. An improved understanding of potential molecular mechanisms can help develop prevention and treatment strategies for lithium-associated renal disease.
Methods
We conducted a systematic literature search using MEDLINE, Embase, and PsychINFO including English-language original research articles published prior to November 2015 that specifically investigated lithium’s effects on nephrogenic diabetes insipidus (NDI) and chronic kidney disease (CKD), using molecular markers.
Results
From a total of 3510 records, 71 pre-clinical studies and two relevant clinical studies were identified. Molecular alterations were reported in calcium signaling, inositol monophosphate, extracellular-regulated, prostaglandin, sodium/solute transport, G-protein-coupled receptors, nitric oxide, vasopressin/aquaporin, and inflammation-related pathways in lithium-associated renal disease. The majority of studies found that these mechanisms were implicated in NDI, while few studies had examined CKD.
Discussion
Future studies will have to focus on (1) validating the present findings in human subjects and (2) examining CKD, which is the most clinically relevant lithium-associated renal effect. This will improve our understanding of lithium’s biological effects, as well as inform a personalized medicine approach, which could lead to safer lithium prescribing and less renal adverse events. |
| doi_str_mv | 10.1007/s11255-016-1352-6 |
| format | Article |
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Lithium is an essential treatment in bipolar disorder and treatment-resistant depression; however, its use has been limited by concerns regarding its renal adverse effects. An improved understanding of potential molecular mechanisms can help develop prevention and treatment strategies for lithium-associated renal disease.
Methods
We conducted a systematic literature search using MEDLINE, Embase, and PsychINFO including English-language original research articles published prior to November 2015 that specifically investigated lithium’s effects on nephrogenic diabetes insipidus (NDI) and chronic kidney disease (CKD), using molecular markers.
Results
From a total of 3510 records, 71 pre-clinical studies and two relevant clinical studies were identified. Molecular alterations were reported in calcium signaling, inositol monophosphate, extracellular-regulated, prostaglandin, sodium/solute transport, G-protein-coupled receptors, nitric oxide, vasopressin/aquaporin, and inflammation-related pathways in lithium-associated renal disease. The majority of studies found that these mechanisms were implicated in NDI, while few studies had examined CKD.
Discussion
Future studies will have to focus on (1) validating the present findings in human subjects and (2) examining CKD, which is the most clinically relevant lithium-associated renal effect. This will improve our understanding of lithium’s biological effects, as well as inform a personalized medicine approach, which could lead to safer lithium prescribing and less renal adverse events.</description><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-016-1352-6</identifier><identifier>PMID: 27357223</identifier><identifier>CODEN: IURNAE</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animals ; Aquaporins - metabolism ; Calcium - metabolism ; Diabetes Insipidus, Nephrogenic - chemically induced ; Diabetes Insipidus, Nephrogenic - metabolism ; Humans ; Lithium - adverse effects ; Medicine ; Medicine & Public Health ; Nephrology ; Nephrology – Review ; Prostaglandins - metabolism ; Receptors, G-Protein-Coupled - metabolism ; Renal Insufficiency, Chronic - chemically induced ; Renal Insufficiency, Chronic - metabolism ; Signal Transduction ; Sodium - metabolism ; Symporters - metabolism ; Urology ; Vasopressins - metabolism</subject><ispartof>International Urology and Nephrology, 2016-11, Vol.48 (11), p.1843-1853</ispartof><rights>Springer Science+Business Media Dordrecht 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-98a9e0600c859654e9c8deeaac7d70792a0b388813f1c576e40be11e789eae343</citedby><cites>FETCH-LOGICAL-c405t-98a9e0600c859654e9c8deeaac7d70792a0b388813f1c576e40be11e789eae343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11255-016-1352-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11255-016-1352-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>313,314,780,784,792,27922,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27357223$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rej, Soham</creatorcontrib><creatorcontrib>Pira, Shamira</creatorcontrib><creatorcontrib>Marshe, Victoria</creatorcontrib><creatorcontrib>Do, André</creatorcontrib><creatorcontrib>Elie, Dominique</creatorcontrib><creatorcontrib>Looper, Karl J.</creatorcontrib><creatorcontrib>Herrmann, Nathan</creatorcontrib><creatorcontrib>Müller, Daniel J.</creatorcontrib><title>Molecular mechanisms in lithium-associated renal disease: a systematic review</title><title>International Urology and Nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description>Purpose
Lithium is an essential treatment in bipolar disorder and treatment-resistant depression; however, its use has been limited by concerns regarding its renal adverse effects. An improved understanding of potential molecular mechanisms can help develop prevention and treatment strategies for lithium-associated renal disease.
Methods
We conducted a systematic literature search using MEDLINE, Embase, and PsychINFO including English-language original research articles published prior to November 2015 that specifically investigated lithium’s effects on nephrogenic diabetes insipidus (NDI) and chronic kidney disease (CKD), using molecular markers.
Results
From a total of 3510 records, 71 pre-clinical studies and two relevant clinical studies were identified. Molecular alterations were reported in calcium signaling, inositol monophosphate, extracellular-regulated, prostaglandin, sodium/solute transport, G-protein-coupled receptors, nitric oxide, vasopressin/aquaporin, and inflammation-related pathways in lithium-associated renal disease. The majority of studies found that these mechanisms were implicated in NDI, while few studies had examined CKD.
Discussion
Future studies will have to focus on (1) validating the present findings in human subjects and (2) examining CKD, which is the most clinically relevant lithium-associated renal effect. This will improve our understanding of lithium’s biological effects, as well as inform a personalized medicine approach, which could lead to safer lithium prescribing and less renal adverse events.</description><subject>Animals</subject><subject>Aquaporins - metabolism</subject><subject>Calcium - metabolism</subject><subject>Diabetes Insipidus, Nephrogenic - chemically induced</subject><subject>Diabetes Insipidus, Nephrogenic - metabolism</subject><subject>Humans</subject><subject>Lithium - adverse effects</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephrology</subject><subject>Nephrology – Review</subject><subject>Prostaglandins - metabolism</subject><subject>Receptors, G-Protein-Coupled - metabolism</subject><subject>Renal Insufficiency, Chronic - chemically induced</subject><subject>Renal Insufficiency, Chronic - metabolism</subject><subject>Signal Transduction</subject><subject>Sodium - metabolism</subject><subject>Symporters - metabolism</subject><subject>Urology</subject><subject>Vasopressins - metabolism</subject><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkU1rFEEQhhsxmDX6A3KRAS9eOqnqnv4YbxKMBhJy0XPT21NrOsxH7Jox7L93NhuDCEJOdain3qriEeIY4QQB3CkjKmMkoJWojZL2hVihcVoq4-uXYgUaUKJV-lC8Zr4FgMYDvBKHymnjlNIrcXU1dpTmLpaqp3QTh8w9V3moujzd5LmXkXlMOU7UVoWG2FVtZopMH6tY8ZYn6uOU09L7len-jTjYxI7p7WM9Et_PP387-yovr79cnH26lKkGM8nGx4bAAiRvGmtqapJviWJMrnXgGhVhrb33qDeYjLNUw5oQyfmGIulaH4kP-9y7Mv6ciafQZ07UdXGgceaAXjutmtqaZ6DKOvBocEHf_4PejnNZfn6glsPq2uwCcU-lMjIX2oS7kvtYtgEh7LSEvZawaAk7LcEuM-8ek-d1T-3TxB8PC6D2AC-t4QeVv1b_N_U30jCWZA</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Rej, Soham</creator><creator>Pira, Shamira</creator><creator>Marshe, Victoria</creator><creator>Do, André</creator><creator>Elie, Dominique</creator><creator>Looper, Karl J.</creator><creator>Herrmann, Nathan</creator><creator>Müller, Daniel J.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20161101</creationdate><title>Molecular mechanisms in lithium-associated renal disease: a systematic review</title><author>Rej, Soham ; Pira, Shamira ; Marshe, Victoria ; Do, André ; Elie, Dominique ; Looper, Karl J. ; Herrmann, Nathan ; Müller, Daniel J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-98a9e0600c859654e9c8deeaac7d70792a0b388813f1c576e40be11e789eae343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Aquaporins - metabolism</topic><topic>Calcium - metabolism</topic><topic>Diabetes Insipidus, Nephrogenic - chemically induced</topic><topic>Diabetes Insipidus, Nephrogenic - metabolism</topic><topic>Humans</topic><topic>Lithium - adverse effects</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nephrology</topic><topic>Nephrology – Review</topic><topic>Prostaglandins - metabolism</topic><topic>Receptors, G-Protein-Coupled - metabolism</topic><topic>Renal Insufficiency, Chronic - chemically induced</topic><topic>Renal Insufficiency, Chronic - metabolism</topic><topic>Signal Transduction</topic><topic>Sodium - metabolism</topic><topic>Symporters - metabolism</topic><topic>Urology</topic><topic>Vasopressins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rej, Soham</creatorcontrib><creatorcontrib>Pira, Shamira</creatorcontrib><creatorcontrib>Marshe, Victoria</creatorcontrib><creatorcontrib>Do, André</creatorcontrib><creatorcontrib>Elie, Dominique</creatorcontrib><creatorcontrib>Looper, Karl J.</creatorcontrib><creatorcontrib>Herrmann, Nathan</creatorcontrib><creatorcontrib>Müller, Daniel J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International Urology and Nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rej, Soham</au><au>Pira, Shamira</au><au>Marshe, Victoria</au><au>Do, André</au><au>Elie, Dominique</au><au>Looper, Karl J.</au><au>Herrmann, Nathan</au><au>Müller, Daniel J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular mechanisms in lithium-associated renal disease: a systematic review</atitle><jtitle>International Urology and Nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>48</volume><issue>11</issue><spage>1843</spage><epage>1853</epage><pages>1843-1853</pages><issn>0301-1623</issn><eissn>1573-2584</eissn><coden>IURNAE</coden><abstract>Purpose
Lithium is an essential treatment in bipolar disorder and treatment-resistant depression; however, its use has been limited by concerns regarding its renal adverse effects. An improved understanding of potential molecular mechanisms can help develop prevention and treatment strategies for lithium-associated renal disease.
Methods
We conducted a systematic literature search using MEDLINE, Embase, and PsychINFO including English-language original research articles published prior to November 2015 that specifically investigated lithium’s effects on nephrogenic diabetes insipidus (NDI) and chronic kidney disease (CKD), using molecular markers.
Results
From a total of 3510 records, 71 pre-clinical studies and two relevant clinical studies were identified. Molecular alterations were reported in calcium signaling, inositol monophosphate, extracellular-regulated, prostaglandin, sodium/solute transport, G-protein-coupled receptors, nitric oxide, vasopressin/aquaporin, and inflammation-related pathways in lithium-associated renal disease. The majority of studies found that these mechanisms were implicated in NDI, while few studies had examined CKD.
Discussion
Future studies will have to focus on (1) validating the present findings in human subjects and (2) examining CKD, which is the most clinically relevant lithium-associated renal effect. This will improve our understanding of lithium’s biological effects, as well as inform a personalized medicine approach, which could lead to safer lithium prescribing and less renal adverse events.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>27357223</pmid><doi>10.1007/s11255-016-1352-6</doi><tpages>11</tpages></addata></record> |
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| identifier | ISSN: 0301-1623 |
| ispartof | International Urology and Nephrology, 2016-11, Vol.48 (11), p.1843-1853 |
| issn | 0301-1623 1573-2584 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Animals Aquaporins - metabolism Calcium - metabolism Diabetes Insipidus, Nephrogenic - chemically induced Diabetes Insipidus, Nephrogenic - metabolism Humans Lithium - adverse effects Medicine Medicine & Public Health Nephrology Nephrology – Review Prostaglandins - metabolism Receptors, G-Protein-Coupled - metabolism Renal Insufficiency, Chronic - chemically induced Renal Insufficiency, Chronic - metabolism Signal Transduction Sodium - metabolism Symporters - metabolism Urology Vasopressins - metabolism |
| title | Molecular mechanisms in lithium-associated renal disease: a systematic review |
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