Collagen: a network for regenerative medicine
The basic building block of the extra-cellular matrix in native tissue is collagen. As a structural protein, collagen has an inherent biocompatibility making it an ideal material for regenerative medicine. Cellular response, mediated by integrins, is dictated by the structure and chemistry of the co...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2016-01, Vol.4 (4), p.6484-6496 |
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| container_title | Journal of materials chemistry. B, Materials for biology and medicine |
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| creator | Pawelec, K. M Best, S. M Cameron, R. E |
| description | The basic building block of the extra-cellular matrix in native tissue is collagen. As a structural protein, collagen has an inherent biocompatibility making it an ideal material for regenerative medicine. Cellular response, mediated by integrins, is dictated by the structure and chemistry of the collagen fibers. Fiber formation,
via
fibrillogenesis, can be controlled
in vitro
by several factors: pH, ionic strength, and collagen structure. After formation, fibers are stabilized
via
cross-linking. The final bioactivity of collagen scaffolds is a result of both processes. By considering each step of fabrication, scaffolds can be tailored for the specific needs of each tissue, improving their therapeutic potential.
Collagen, as the basic building block of native extracellular matrix, possesses an inherent biocompatibility which makes it ideal for regenerative medicine. |
| doi_str_mv | 10.1039/c6tb00807k |
| format | Article |
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via
fibrillogenesis, can be controlled
in vitro
by several factors: pH, ionic strength, and collagen structure. After formation, fibers are stabilized
via
cross-linking. The final bioactivity of collagen scaffolds is a result of both processes. By considering each step of fabrication, scaffolds can be tailored for the specific needs of each tissue, improving their therapeutic potential.
Collagen, as the basic building block of native extracellular matrix, possesses an inherent biocompatibility which makes it ideal for regenerative medicine.</description><identifier>ISSN: 2050-750X</identifier><identifier>ISSN: 2050-7518</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/c6tb00807k</identifier><identifier>PMID: 27928505</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>bioactive properties ; Biochemistry ; biocompatibility ; Biology ; Chemistry ; collagen ; Collagens ; crosslinking ; Fibers ; Formations ; integrins ; ionic strength ; medicine ; Regeneration (physiology) ; Scaffolds ; structural proteins ; therapeutics ; Tissue engineering</subject><ispartof>Journal of materials chemistry. B, Materials for biology and medicine, 2016-01, Vol.4 (4), p.6484-6496</ispartof><rights>This journal is © The Royal Society of Chemistry 2016 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c632t-dc68ab78a89f6f09492aedb4530288df08d03c2623934dfc22bf0846fa0f89f03</citedby><cites>FETCH-LOGICAL-c632t-dc68ab78a89f6f09492aedb4530288df08d03c2623934dfc22bf0846fa0f89f03</cites><orcidid>0000-0003-2606-4136</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27928505$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pawelec, K. M</creatorcontrib><creatorcontrib>Best, S. M</creatorcontrib><creatorcontrib>Cameron, R. E</creatorcontrib><title>Collagen: a network for regenerative medicine</title><title>Journal of materials chemistry. B, Materials for biology and medicine</title><addtitle>J Mater Chem B</addtitle><description>The basic building block of the extra-cellular matrix in native tissue is collagen. As a structural protein, collagen has an inherent biocompatibility making it an ideal material for regenerative medicine. Cellular response, mediated by integrins, is dictated by the structure and chemistry of the collagen fibers. Fiber formation,
via
fibrillogenesis, can be controlled
in vitro
by several factors: pH, ionic strength, and collagen structure. After formation, fibers are stabilized
via
cross-linking. The final bioactivity of collagen scaffolds is a result of both processes. By considering each step of fabrication, scaffolds can be tailored for the specific needs of each tissue, improving their therapeutic potential.
Collagen, as the basic building block of native extracellular matrix, possesses an inherent biocompatibility which makes it ideal for regenerative medicine.</description><subject>bioactive properties</subject><subject>Biochemistry</subject><subject>biocompatibility</subject><subject>Biology</subject><subject>Chemistry</subject><subject>collagen</subject><subject>Collagens</subject><subject>crosslinking</subject><subject>Fibers</subject><subject>Formations</subject><subject>integrins</subject><subject>ionic strength</subject><subject>medicine</subject><subject>Regeneration (physiology)</subject><subject>Scaffolds</subject><subject>structural proteins</subject><subject>therapeutics</subject><subject>Tissue engineering</subject><issn>2050-750X</issn><issn>2050-7518</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNks0vBDEYxhshCHtxJ-MmkuFtO_1ykLDxFRKXlbg1nU7LsDuz2tkV_72yLC7opc37_Pq0b58itIFhDwNV-5Z3JYAE8biAVgkwyAXDcnG-htsV1IvxAdKQmEtaLKMVIhSRDNgqyvvtcGjuXHOQmaxx3XMbHjPfhiy4VHTBdPXUZSNX1bZu3Dpa8mYYXe9jXkM3pyeD_nl-dX120T-6yi2npMsry6UphTRSee5BFYoYV5UFo0CkrDzICqglnFBFi8pbQspUK7g34NMWoGvocOY7npTpbOuaLpihHod6ZMKLbk2tfypNfa_v2qlmmFBORTLY-TAI7dPExU6P6mhdarVx7SRqQgSWDGOh_kSxLISUXEHxH5SlJDAX_0DTLYmimCV0d4ba0MYYnJ_3iUG_Zaz7fHD8nvFlgre-v8wc_Uw0AZszIEQ7V78-SdK3f9P1uPL0FZqmtRg</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Pawelec, K. M</creator><creator>Best, S. M</creator><creator>Cameron, R. E</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2606-4136</orcidid></search><sort><creationdate>20160101</creationdate><title>Collagen: a network for regenerative medicine</title><author>Pawelec, K. M ; Best, S. M ; Cameron, R. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c632t-dc68ab78a89f6f09492aedb4530288df08d03c2623934dfc22bf0846fa0f89f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>bioactive properties</topic><topic>Biochemistry</topic><topic>biocompatibility</topic><topic>Biology</topic><topic>Chemistry</topic><topic>collagen</topic><topic>Collagens</topic><topic>crosslinking</topic><topic>Fibers</topic><topic>Formations</topic><topic>integrins</topic><topic>ionic strength</topic><topic>medicine</topic><topic>Regeneration (physiology)</topic><topic>Scaffolds</topic><topic>structural proteins</topic><topic>therapeutics</topic><topic>Tissue engineering</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pawelec, K. M</creatorcontrib><creatorcontrib>Best, S. M</creatorcontrib><creatorcontrib>Cameron, R. E</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pawelec, K. M</au><au>Best, S. M</au><au>Cameron, R. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Collagen: a network for regenerative medicine</atitle><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle><addtitle>J Mater Chem B</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>4</volume><issue>4</issue><spage>6484</spage><epage>6496</epage><pages>6484-6496</pages><issn>2050-750X</issn><issn>2050-7518</issn><eissn>2050-7518</eissn><abstract>The basic building block of the extra-cellular matrix in native tissue is collagen. As a structural protein, collagen has an inherent biocompatibility making it an ideal material for regenerative medicine. Cellular response, mediated by integrins, is dictated by the structure and chemistry of the collagen fibers. Fiber formation,
via
fibrillogenesis, can be controlled
in vitro
by several factors: pH, ionic strength, and collagen structure. After formation, fibers are stabilized
via
cross-linking. The final bioactivity of collagen scaffolds is a result of both processes. By considering each step of fabrication, scaffolds can be tailored for the specific needs of each tissue, improving their therapeutic potential.
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| identifier | ISSN: 2050-750X |
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| issn | 2050-750X 2050-7518 2050-7518 |
| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | bioactive properties Biochemistry biocompatibility Biology Chemistry collagen Collagens crosslinking Fibers Formations integrins ionic strength medicine Regeneration (physiology) Scaffolds structural proteins therapeutics Tissue engineering |
| title | Collagen: a network for regenerative medicine |
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