Acute and Repeated Dose Toxicity Studies of Different β-Cyclodextrin-Based Nanosponge Formulations

Nanosponges (NS) show promising results in different fields such as medicine, agriculture, water purification, fire engineering and so on. The present study was designed to evaluate toxicity of different NS formulations (namely, S1–S6) synthesized with different cross-linking agents such as carbonyl...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2015-05, Vol.104 (5), p.1856-1863
Hauptverfasser:	Shende, Pravin, Kulkarni, Yogesh A., Gaud, R.S., Deshmukh, Kiran, Cavalli, Roberta, Trotta, Francesco, Caldera, Fabrizio
Format:	Artikel
Sprache:	eng
Schlagworte:	acute toxicity Animals beta-Cyclodextrins - administration & dosage beta-Cyclodextrins - chemistry beta-Cyclodextrins - toxicity bulk condensation method Chemistry, Pharmaceutical complexation cyclodextrin nanosponge Dose-Response Relationship, Drug Female interfacial condensation method Male Nanospheres - administration & dosage Nanospheres - chemistry Nanospheres - toxicity nanotechnology OECD guidelines pharmacokinetics protein delivery Rats Rats, Wistar repeated dose toxicity surface active Toxicity Tests, Acute - methods
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