Resveratrol limits diabetes-associated cognitive decline in rats by preventing oxidative stress and inflammation and modulating hippocampal structural synaptic plasticity
Abstract Many patients with diabetes are at increased risk of cognitive dysfunction and dementia. Resveratrol, a polyphenol found mainly in grapes and red wine, has antioxidant, anti-inflammatory, and neuroprotective activities. Studies demonstrated that resveratrol could prevent memory deficits and...
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| Veröffentlicht in: | Brain research 2016-11, Vol.1650, p.1-9 |
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| creator | Tian, Xia Liu, Yanlin Ren, Guangwei Yin, Ling Liang, Xiaoyan Geng, Tao Dang, Heqin An, Rufeng |
| description | Abstract Many patients with diabetes are at increased risk of cognitive dysfunction and dementia. Resveratrol, a polyphenol found mainly in grapes and red wine, has antioxidant, anti-inflammatory, and neuroprotective activities. Studies demonstrated that resveratrol could prevent memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats. However, whether administration of resveratrol could modulate the structural synaptic plasticity in diabetic rats remains unknown. Therefore, we tested its influence against cognitive dysfunction as well as on hippocampal structural synaptic plasticity in streptozotocin-induced diabetic rats. Our results showed that the cognitive performances in diabetic group were markedly deteriorated, accompanied by noticeable alterations in oxidative as well as inflammation parameters, SYN and GAP-43 expression were reduced in the hippocampus. In contrast, chronic treatment with resveratrol (10, 20 mg/kg) improved neuronal injury and cognitive performance by attenuating oxidative stress and inflammation as well as inhibiting synapse loss in diabetic rats. In conclusion, the present study suggested that oral supplementation of resveratrol might be a potential therapeutic strategy for the treatment and/or prevention of diabetic encephalopathy. |
| doi_str_mv | 10.1016/j.brainres.2016.08.032 |
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Resveratrol, a polyphenol found mainly in grapes and red wine, has antioxidant, anti-inflammatory, and neuroprotective activities. Studies demonstrated that resveratrol could prevent memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats. However, whether administration of resveratrol could modulate the structural synaptic plasticity in diabetic rats remains unknown. Therefore, we tested its influence against cognitive dysfunction as well as on hippocampal structural synaptic plasticity in streptozotocin-induced diabetic rats. Our results showed that the cognitive performances in diabetic group were markedly deteriorated, accompanied by noticeable alterations in oxidative as well as inflammation parameters, SYN and GAP-43 expression were reduced in the hippocampus. In contrast, chronic treatment with resveratrol (10, 20 mg/kg) improved neuronal injury and cognitive performance by attenuating oxidative stress and inflammation as well as inhibiting synapse loss in diabetic rats. In conclusion, the present study suggested that oral supplementation of resveratrol might be a potential therapeutic strategy for the treatment and/or prevention of diabetic encephalopathy.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2016.08.032</identifier><identifier>PMID: 27566063</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Antioxidants - pharmacology ; Blood Glucose - metabolism ; Cognition - drug effects ; Cognition Disorders - etiology ; Cognitive Dysfunction ; Cognitive function ; Diabetes ; Diabetes Complications ; Diabetes Mellitus, Experimental - complications ; Hippocampus - drug effects ; Inflammation - metabolism ; Male ; Maze Learning - drug effects ; Memory - drug effects ; Neurology ; Neuronal Plasticity - drug effects ; Oxidative stress ; Oxidative Stress - drug effects ; Rats ; Rats, Sprague-Dawley ; Resveratrol ; Stilbenes - metabolism ; Stilbenes - pharmacology ; Structural synaptic plasticity ; Superoxide Dismutase - metabolism ; Synapses - drug effects ; TNF-α ; Vitaceae</subject><ispartof>Brain research, 2016-11, Vol.1650, p.1-9</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-9ccad34922304eb04dcabbd4e977f858544c69c0734ddb35f179b31349d869793</citedby><cites>FETCH-LOGICAL-c522t-9ccad34922304eb04dcabbd4e977f858544c69c0734ddb35f179b31349d869793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006899316305856$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27566063$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tian, Xia</creatorcontrib><creatorcontrib>Liu, Yanlin</creatorcontrib><creatorcontrib>Ren, Guangwei</creatorcontrib><creatorcontrib>Yin, Ling</creatorcontrib><creatorcontrib>Liang, Xiaoyan</creatorcontrib><creatorcontrib>Geng, Tao</creatorcontrib><creatorcontrib>Dang, Heqin</creatorcontrib><creatorcontrib>An, Rufeng</creatorcontrib><title>Resveratrol limits diabetes-associated cognitive decline in rats by preventing oxidative stress and inflammation and modulating hippocampal structural synaptic plasticity</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Abstract Many patients with diabetes are at increased risk of cognitive dysfunction and dementia. Resveratrol, a polyphenol found mainly in grapes and red wine, has antioxidant, anti-inflammatory, and neuroprotective activities. Studies demonstrated that resveratrol could prevent memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats. However, whether administration of resveratrol could modulate the structural synaptic plasticity in diabetic rats remains unknown. Therefore, we tested its influence against cognitive dysfunction as well as on hippocampal structural synaptic plasticity in streptozotocin-induced diabetic rats. Our results showed that the cognitive performances in diabetic group were markedly deteriorated, accompanied by noticeable alterations in oxidative as well as inflammation parameters, SYN and GAP-43 expression were reduced in the hippocampus. In contrast, chronic treatment with resveratrol (10, 20 mg/kg) improved neuronal injury and cognitive performance by attenuating oxidative stress and inflammation as well as inhibiting synapse loss in diabetic rats. In conclusion, the present study suggested that oral supplementation of resveratrol might be a potential therapeutic strategy for the treatment and/or prevention of diabetic encephalopathy.</description><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Blood Glucose - metabolism</subject><subject>Cognition - drug effects</subject><subject>Cognition Disorders - etiology</subject><subject>Cognitive Dysfunction</subject><subject>Cognitive function</subject><subject>Diabetes</subject><subject>Diabetes Complications</subject><subject>Diabetes Mellitus, Experimental - complications</subject><subject>Hippocampus - drug effects</subject><subject>Inflammation - metabolism</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Memory - drug effects</subject><subject>Neurology</subject><subject>Neuronal Plasticity - drug effects</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Resveratrol</subject><subject>Stilbenes - metabolism</subject><subject>Stilbenes - pharmacology</subject><subject>Structural synaptic plasticity</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Synapses - drug effects</subject><subject>TNF-α</subject><subject>Vitaceae</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk2P1DAMhisEYoeFv7DKkUuHNGnT5oJAK76klZD4OEdp4lk8pElJ0hHzl_iVpDO7HLjAybH1vHbk11V11dBtQxvxYr8do0YfIW1Zybd02FLOHlSbZuhZLVhLH1YbSqmoByn5RfUkpX1JOZf0cXXB-k4IKvim-vUJ0gGizjE44nDCnIhFPUKGVOuUgkGdwRITbj1mPACxYBx6IOhJkSUyHskc4QA-o78l4SdafeJSLp9LRHtb0J3T01TqwZ8KU7CL0yfBN5znYPQ0a7dKFpOXuD6PXs8ZDZmdTiViPj6tHu20S_DsLl5WX9---XL9vr75-O7D9eub2nSM5Voaoy1vJWOctjDS1ho9jrYF2fe7oRu6tjVCGtrz1tqRd7umlyNvisIOQvaSX1bPz33nGH4skLKaMBlwTnsIS1LNwHvOCij-B-14J3u6dhVn1MSQUoSdmiNOOh5VQ9Vqqdqre0vVaqmigyqWFuHV3YxlnMD-kd17WIBXZwDKUg4IUSWD4A1YjGCysgH_PePlXy1Wj9Fo9x2OkPZhib6sXDUqMUXV5_Ww1rtqBKdlo4L_BvVi0EU</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Tian, Xia</creator><creator>Liu, Yanlin</creator><creator>Ren, Guangwei</creator><creator>Yin, Ling</creator><creator>Liang, Xiaoyan</creator><creator>Geng, Tao</creator><creator>Dang, Heqin</creator><creator>An, Rufeng</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20161101</creationdate><title>Resveratrol limits diabetes-associated cognitive decline in rats by preventing oxidative stress and inflammation and modulating hippocampal structural synaptic plasticity</title><author>Tian, Xia ; Liu, Yanlin ; Ren, Guangwei ; Yin, Ling ; Liang, Xiaoyan ; Geng, Tao ; Dang, Heqin ; An, Rufeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-9ccad34922304eb04dcabbd4e977f858544c69c0734ddb35f179b31349d869793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Blood Glucose - metabolism</topic><topic>Cognition - drug effects</topic><topic>Cognition Disorders - etiology</topic><topic>Cognitive Dysfunction</topic><topic>Cognitive function</topic><topic>Diabetes</topic><topic>Diabetes Complications</topic><topic>Diabetes Mellitus, Experimental - complications</topic><topic>Hippocampus - drug effects</topic><topic>Inflammation - metabolism</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Memory - drug effects</topic><topic>Neurology</topic><topic>Neuronal Plasticity - drug effects</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Resveratrol</topic><topic>Stilbenes - metabolism</topic><topic>Stilbenes - pharmacology</topic><topic>Structural synaptic plasticity</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Synapses - drug effects</topic><topic>TNF-α</topic><topic>Vitaceae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tian, Xia</creatorcontrib><creatorcontrib>Liu, Yanlin</creatorcontrib><creatorcontrib>Ren, Guangwei</creatorcontrib><creatorcontrib>Yin, Ling</creatorcontrib><creatorcontrib>Liang, Xiaoyan</creatorcontrib><creatorcontrib>Geng, Tao</creatorcontrib><creatorcontrib>Dang, Heqin</creatorcontrib><creatorcontrib>An, Rufeng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tian, Xia</au><au>Liu, Yanlin</au><au>Ren, Guangwei</au><au>Yin, Ling</au><au>Liang, Xiaoyan</au><au>Geng, Tao</au><au>Dang, Heqin</au><au>An, Rufeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resveratrol limits diabetes-associated cognitive decline in rats by preventing oxidative stress and inflammation and modulating hippocampal structural synaptic plasticity</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>1650</volume><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>Abstract Many patients with diabetes are at increased risk of cognitive dysfunction and dementia. Resveratrol, a polyphenol found mainly in grapes and red wine, has antioxidant, anti-inflammatory, and neuroprotective activities. Studies demonstrated that resveratrol could prevent memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats. However, whether administration of resveratrol could modulate the structural synaptic plasticity in diabetic rats remains unknown. Therefore, we tested its influence against cognitive dysfunction as well as on hippocampal structural synaptic plasticity in streptozotocin-induced diabetic rats. Our results showed that the cognitive performances in diabetic group were markedly deteriorated, accompanied by noticeable alterations in oxidative as well as inflammation parameters, SYN and GAP-43 expression were reduced in the hippocampus. In contrast, chronic treatment with resveratrol (10, 20 mg/kg) improved neuronal injury and cognitive performance by attenuating oxidative stress and inflammation as well as inhibiting synapse loss in diabetic rats. In conclusion, the present study suggested that oral supplementation of resveratrol might be a potential therapeutic strategy for the treatment and/or prevention of diabetic encephalopathy.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>27566063</pmid><doi>10.1016/j.brainres.2016.08.032</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Antioxidants - pharmacology Blood Glucose - metabolism Cognition - drug effects Cognition Disorders - etiology Cognitive Dysfunction Cognitive function Diabetes Diabetes Complications Diabetes Mellitus, Experimental - complications Hippocampus - drug effects Inflammation - metabolism Male Maze Learning - drug effects Memory - drug effects Neurology Neuronal Plasticity - drug effects Oxidative stress Oxidative Stress - drug effects Rats Rats, Sprague-Dawley Resveratrol Stilbenes - metabolism Stilbenes - pharmacology Structural synaptic plasticity Superoxide Dismutase - metabolism Synapses - drug effects TNF-α Vitaceae |
| title | Resveratrol limits diabetes-associated cognitive decline in rats by preventing oxidative stress and inflammation and modulating hippocampal structural synaptic plasticity |
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