Serum concentration of CD40L is elevated in inflammatory demyelinating diseases
Abstract It is believed that auto-inflammatory activity, including cellular and humoral immunity responses, especially T cell–B cell collaboration, is one of the most important components of the pathogenesis of inflammatory demyelinating disease. CD40L is critical for T cell–B cell collaboration. Ac...
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| Veröffentlicht in: | Journal of neuroimmunology 2016-10, Vol.299, p.66-69 |
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| container_title | Journal of neuroimmunology |
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| creator | Zhong, Xiaonan Wang, Honghao Ye, Zhiwei Qiu, Wei Lu, Zhengqi Li, Rui Shu, Yaqing Chang, Yanyu Hu, Xueqiang |
| description | Abstract It is believed that auto-inflammatory activity, including cellular and humoral immunity responses, especially T cell–B cell collaboration, is one of the most important components of the pathogenesis of inflammatory demyelinating disease. CD40L is critical for T cell–B cell collaboration. Actually, serum CD40L levels have been shown to increase in MS. In the present study, serum CD40L levels were measured by an enzyme-linked immunosorbent assay (ELISA) in NMO
( n = 27) and MS ( n = 19) patients and controls ( n = 14). We revealed elevation of CD40L in NMO patients, and discovered a correlation between CD40L and humoral immunity in inflammatory demyelinating disease. |
| doi_str_mv | 10.1016/j.jneuroim.2016.08.015 |
| format | Article |
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( n = 27) and MS ( n = 19) patients and controls ( n = 14). We revealed elevation of CD40L in NMO patients, and discovered a correlation between CD40L and humoral immunity in inflammatory demyelinating disease.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2016.08.015</identifier><identifier>PMID: 27725124</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Allergy and Immunology ; Biomarkers - blood ; CD40 Ligand - blood ; CD40 Ligand - immunology ; CD40L ; Child ; Demyelinating Diseases - blood ; Demyelinating Diseases - diagnosis ; Demyelinating Diseases - immunology ; Female ; Humans ; Immunity, Humoral - immunology ; Male ; Middle Aged ; Multiple sclerosis ; Multiple Sclerosis, Relapsing-Remitting - blood ; Multiple Sclerosis, Relapsing-Remitting - diagnosis ; Multiple Sclerosis, Relapsing-Remitting - immunology ; Neurology ; Neuromyelitis optica ; Neuromyelitis Optica - blood ; Neuromyelitis Optica - diagnosis ; Neuromyelitis Optica - immunology ; Serum ; Young Adult</subject><ispartof>Journal of neuroimmunology, 2016-10, Vol.299, p.66-69</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-d9c7c934787fc1de75221ebb1227c98bc6fc832e1fb8e55019c513da49ea3a9a3</citedby><cites>FETCH-LOGICAL-c522t-d9c7c934787fc1de75221ebb1227c98bc6fc832e1fb8e55019c513da49ea3a9a3</cites><orcidid>0000-0002-1187-7612</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jneuroim.2016.08.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27725124$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhong, Xiaonan</creatorcontrib><creatorcontrib>Wang, Honghao</creatorcontrib><creatorcontrib>Ye, Zhiwei</creatorcontrib><creatorcontrib>Qiu, Wei</creatorcontrib><creatorcontrib>Lu, Zhengqi</creatorcontrib><creatorcontrib>Li, Rui</creatorcontrib><creatorcontrib>Shu, Yaqing</creatorcontrib><creatorcontrib>Chang, Yanyu</creatorcontrib><creatorcontrib>Hu, Xueqiang</creatorcontrib><title>Serum concentration of CD40L is elevated in inflammatory demyelinating diseases</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Abstract It is believed that auto-inflammatory activity, including cellular and humoral immunity responses, especially T cell–B cell collaboration, is one of the most important components of the pathogenesis of inflammatory demyelinating disease. CD40L is critical for T cell–B cell collaboration. Actually, serum CD40L levels have been shown to increase in MS. In the present study, serum CD40L levels were measured by an enzyme-linked immunosorbent assay (ELISA) in NMO
( n = 27) and MS ( n = 19) patients and controls ( n = 14). We revealed elevation of CD40L in NMO patients, and discovered a correlation between CD40L and humoral immunity in inflammatory demyelinating disease.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Allergy and Immunology</subject><subject>Biomarkers - blood</subject><subject>CD40 Ligand - blood</subject><subject>CD40 Ligand - immunology</subject><subject>CD40L</subject><subject>Child</subject><subject>Demyelinating Diseases - blood</subject><subject>Demyelinating Diseases - diagnosis</subject><subject>Demyelinating Diseases - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunity, Humoral - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis, Relapsing-Remitting - blood</subject><subject>Multiple Sclerosis, Relapsing-Remitting - diagnosis</subject><subject>Multiple Sclerosis, Relapsing-Remitting - immunology</subject><subject>Neurology</subject><subject>Neuromyelitis optica</subject><subject>Neuromyelitis Optica - blood</subject><subject>Neuromyelitis Optica - diagnosis</subject><subject>Neuromyelitis Optica - immunology</subject><subject>Serum</subject><subject>Young Adult</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1r3DAQQEVpaTbb_oXgYy529GFZ8qW0bJo0sJBDWuhNyNK4yLWlRLIX9t9XZpMeemlgQMzozQy8QeiC4Ipg0lwN1eBhicFNFc15hWWFCX-DNkQKWsqakrdokz94yQWVZ-g8pQFngtXte3RGhaCc0HqD7h8gLlNhgjfg56hnF3wR-mJ3XeN94VIBIxz0DLZwPkc_6mnSc4jHwsJ0hNH53OJ_FdYl0AnSB_Su12OCj8_vFv24-fp9963c39_e7b7sS8MpnUvbGmFaVgspekMsiFwl0HWE0lyXnWl6IxkF0ncSOMekNZwwq-sWNNOtZlt0eZr7GMPTAmlWk0sGxlF7CEtSRDLBqGg4ew3KmZCS04w2J9TEkFKEXj1GN-l4VASr1bsa1It3tXpXWKrV6hZdPO9Yugns37YX0Rn4fAIgSzk4iCoZB1m6dRHMrGxw_9_x6Z8RJut3Ro-_4QhpCEv0WbkiKlGF1cN6_fX4pGGYYvaT_QFtl6x6</recordid><startdate>20161015</startdate><enddate>20161015</enddate><creator>Zhong, Xiaonan</creator><creator>Wang, Honghao</creator><creator>Ye, Zhiwei</creator><creator>Qiu, Wei</creator><creator>Lu, Zhengqi</creator><creator>Li, Rui</creator><creator>Shu, Yaqing</creator><creator>Chang, Yanyu</creator><creator>Hu, Xueqiang</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><orcidid>https://orcid.org/0000-0002-1187-7612</orcidid></search><sort><creationdate>20161015</creationdate><title>Serum concentration of CD40L is elevated in inflammatory demyelinating diseases</title><author>Zhong, Xiaonan ; Wang, Honghao ; Ye, Zhiwei ; Qiu, Wei ; Lu, Zhengqi ; Li, Rui ; Shu, Yaqing ; Chang, Yanyu ; Hu, Xueqiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-d9c7c934787fc1de75221ebb1227c98bc6fc832e1fb8e55019c513da49ea3a9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Allergy and Immunology</topic><topic>Biomarkers - blood</topic><topic>CD40 Ligand - blood</topic><topic>CD40 Ligand - immunology</topic><topic>CD40L</topic><topic>Child</topic><topic>Demyelinating Diseases - blood</topic><topic>Demyelinating Diseases - diagnosis</topic><topic>Demyelinating Diseases - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunity, Humoral - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis, Relapsing-Remitting - blood</topic><topic>Multiple Sclerosis, Relapsing-Remitting - diagnosis</topic><topic>Multiple Sclerosis, Relapsing-Remitting - immunology</topic><topic>Neurology</topic><topic>Neuromyelitis optica</topic><topic>Neuromyelitis Optica - blood</topic><topic>Neuromyelitis Optica - diagnosis</topic><topic>Neuromyelitis Optica - immunology</topic><topic>Serum</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhong, Xiaonan</creatorcontrib><creatorcontrib>Wang, Honghao</creatorcontrib><creatorcontrib>Ye, Zhiwei</creatorcontrib><creatorcontrib>Qiu, Wei</creatorcontrib><creatorcontrib>Lu, Zhengqi</creatorcontrib><creatorcontrib>Li, Rui</creatorcontrib><creatorcontrib>Shu, Yaqing</creatorcontrib><creatorcontrib>Chang, Yanyu</creatorcontrib><creatorcontrib>Hu, Xueqiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhong, Xiaonan</au><au>Wang, Honghao</au><au>Ye, Zhiwei</au><au>Qiu, Wei</au><au>Lu, Zhengqi</au><au>Li, Rui</au><au>Shu, Yaqing</au><au>Chang, Yanyu</au><au>Hu, Xueqiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum concentration of CD40L is elevated in inflammatory demyelinating diseases</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2016-10-15</date><risdate>2016</risdate><volume>299</volume><spage>66</spage><epage>69</epage><pages>66-69</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Abstract It is believed that auto-inflammatory activity, including cellular and humoral immunity responses, especially T cell–B cell collaboration, is one of the most important components of the pathogenesis of inflammatory demyelinating disease. CD40L is critical for T cell–B cell collaboration. Actually, serum CD40L levels have been shown to increase in MS. In the present study, serum CD40L levels were measured by an enzyme-linked immunosorbent assay (ELISA) in NMO
( n = 27) and MS ( n = 19) patients and controls ( n = 14). We revealed elevation of CD40L in NMO patients, and discovered a correlation between CD40L and humoral immunity in inflammatory demyelinating disease.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>27725124</pmid><doi>10.1016/j.jneuroim.2016.08.015</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-1187-7612</orcidid></addata></record> |
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| subjects | Adolescent Adult Allergy and Immunology Biomarkers - blood CD40 Ligand - blood CD40 Ligand - immunology CD40L Child Demyelinating Diseases - blood Demyelinating Diseases - diagnosis Demyelinating Diseases - immunology Female Humans Immunity, Humoral - immunology Male Middle Aged Multiple sclerosis Multiple Sclerosis, Relapsing-Remitting - blood Multiple Sclerosis, Relapsing-Remitting - diagnosis Multiple Sclerosis, Relapsing-Remitting - immunology Neurology Neuromyelitis optica Neuromyelitis Optica - blood Neuromyelitis Optica - diagnosis Neuromyelitis Optica - immunology Serum Young Adult |
| title | Serum concentration of CD40L is elevated in inflammatory demyelinating diseases |
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