Long-term metabolic benefits of exenatide in mice are mediated solely via the known glucagon-like peptide 1 receptor

Glucagon-like peptide 1 receptors (GLP-1R) are expressed in multiple tissues and activation results in metabolic benefits including enhanced insulin secretion, slowed gastric emptying, suppressed food intake, and improved hepatic steatosis. Limited and inconclusive knowledge exists regarding whether...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2014-04, Vol.306 (7), p.R490-R498
Hauptverfasser:	Tatarkiewicz, Krystyna, Sablan, Emmanuel J, Polizzi, Clara J, Villescaz, Christiane, Parkes, David G
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Amylases - blood Animals Aspartate Aminotransferases - blood Biomarkers - blood Blood Glucose - drug effects Blood Glucose - metabolism Body Weight - drug effects Eating - drug effects Gastric Emptying - drug effects Glomerular Filtration Rate - drug effects Glucagon-Like Peptide-1 Receptor Glycated Hemoglobin A - metabolism Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - blood Hypoglycemic Agents - pharmacology Infusions, Subcutaneous Insulin Insulin - blood Lipase - blood Liver - drug effects Liver - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Peptides Peptides - administration & dosage Peptides - blood Peptides - pharmacology Receptors, Glucagon - agonists Receptors, Glucagon - genetics Receptors, Glucagon - metabolism Rodents T cell receptors Time Factors Tissues Venoms - administration & dosage Venoms - blood Venoms - pharmacology
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