Increased insulin receptor substrate 2 expression is associated with steatohepatitis and altered lipid metabolism in obese subjects

Objective: The aim of this study was to evaluate whether dysregulation of molecules involved in FOXO1-dependent insulin signaling in the liver is associated with de novo lipogenesis (DNL) and altered lipid metabolism in severely obese subjects. Design: Observational retrospective study. Subjects: We...

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Veröffentlicht in:	International Journal of Obesity 2013-07, Vol.37 (7), p.986-992
Hauptverfasser:	Rametta, R, Mozzi, E, Dongiovanni, P, Motta, B M, Milano, M, Roviaro, G, Fargion, S, Valenti, L
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443/319/2723 631/80/86/2367 692/699/1503/1607/2750 692/699/2743/393 Adult Aged Biological and medical sciences Blotting, Western Body mass index Cellular signal transduction Cholesterol Diabetes Epidemiology Fatty Liver - genetics Fatty Liver - metabolism Fatty Liver - physiopathology Female Forkhead Box Protein O1 Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal surgery Gene Expression Glucose Health Promotion and Disease Prevention High density lipoprotein Histology Humans Insulin Insulin Receptor Substrate Proteins - genetics Insulin Receptor Substrate Proteins - metabolism Insulin resistance Insulin Resistance - genetics Internal Medicine Italy Kinases Lipid Metabolism Lipids Lipogenesis Liver Liver - metabolism Liver diseases Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Metabolic disorders Metabolic syndrome Middle Aged Obesity Obesity, Morbid - genetics Obesity, Morbid - metabolism Obesity, Morbid - physiopathology original-article Other diseases. Semiology Oxidative Stress Pathophysiology Phosphorylation Physiological aspects Proteins Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Public Health Real-Time Polymerase Chain Reaction Receptors Retrospective Studies RNA, Messenger Signal Transduction Sterol Regulatory Element Binding Protein 1 - genetics Sterol Regulatory Element Binding Protein 1 - metabolism Sterols Substrates
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