Formulation and in Vitro Evaluation of Self-microemulsifying Drug Delivery System Containing Fixed-Dose Combination of Atorvastatin and Ezetimibe

This paper focuses on the development and physicochemical characterization of a self-microemulsifying drug delivery system (SMEDDS) containing a fixed-dose combination of atorvastatin (ATR) and ezetimibe (EZT). The solubility of both drugs was determined in excipient screening studies. Ternary-phase...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2015/06/01, Vol.63(6), pp.423-430
Hauptverfasser:	Hwang, Kyu-Mok, Park, Shin-Ae, Kim, Ju-Young, Park, Chun-Woong, Rhee, Yun-Seok, Park, Eun-Seok
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticholesteremic Agents - administration & dosage Anticholesteremic Agents - chemistry atorvastatin calcium Atorvastatin Calcium - administration & dosage Atorvastatin Calcium - chemistry Drug Combinations Drug Delivery Systems Emulsifying Agents - chemistry Excipients - chemistry ezetimibe Ezetimibe - administration & dosage Ezetimibe - chemistry fixed-dose combination Phase Transition self-microemulsifying drug delivery system Solubility solubilization
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