Anti-apoptotic and Beneficial Metabolic Activities of Resveratrol in Type II Gaucher Disease

Gaucher disease (GD) is one of the most common lysosomal storage disorders and is caused by an inherited deficiency in glucocerebrosidase. Resveratrol is a phytoalexin that has many beneficial activities, including anti-oxidant, anti-apoptotic, and neuroprotective effects. The aim of this study was...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2015/06/01, Vol.38(6), pp.913-918
Hauptverfasser:	Yoo, Soojin, Kim, June-Bum
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl-CoA C-Acetyltransferase - metabolism Apoptosis - drug effects Apoptosis Inducing Factor - metabolism bcl-2-Associated X Protein - metabolism Caspase 3 - metabolism Cell Survival - drug effects Cells, Cultured Citrate (si)-Synthase - metabolism Fibroblasts - drug effects Fibroblasts - metabolism Gaucher disease Gaucher Disease - drug therapy Gaucher Disease - metabolism Glucosylceramides - metabolism Humans lysosomal storage disease phytoalexin Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use polyphenol Pyruvate Dehydrogenase Complex - metabolism resveratrol Stilbenes - pharmacology Stilbenes - therapeutic use therapeutics
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