Role of ADH1B rs1229984 and ALDH2 rs671 gene polymorphisms in the development of Alzheimer's disease

In the present study, we investigated the association between ADH1B rs1229984 and ALDH2 rs671 polymorphisms and the development of Alzheimer's disease in a Chinese population. Genotyping of the ADH1B rs1229984 and ALDH2 rs671 polymorphisms was carried out by polymerase chain reaction-restrictio...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Genetics and molecular research 2016-10, Vol.15 (4)
Hauptverfasser:	Ma, L, Lu, Z N
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alcohol Dehydrogenase - genetics Alcohol Drinking - adverse effects Aldehyde Dehydrogenase, Mitochondrial - genetics Alzheimer Disease - genetics Case-Control Studies Demography Epistasis, Genetic Female Genetic Predisposition to Disease Humans Male Polymorphism, Single Nucleotide - genetics Risk Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page
container_issue	4
container_start_page
container_title	Genetics and molecular research
container_volume	15
creator	Ma, L Lu, Z N
description	In the present study, we investigated the association between ADH1B rs1229984 and ALDH2 rs671 polymorphisms and the development of Alzheimer's disease in a Chinese population. Genotyping of the ADH1B rs1229984 and ALDH2 rs671 polymorphisms was carried out by polymerase chain reaction-restriction fragment length polymorphism. Logistic regression analyses revealed that the AA genotype of ADH1B rs1229984 was associated with an increased risk of Alzheimer's disease (OR = 2.54, 95%CI = 1.19-5.41). In addition, ADH1B rs1229984 was also associated with elevated risk of Alzheimer's disease in both dominant (OR = 1.78, 95%CI = 1.09-2.93) and recessive (OR = 2.33, 95%CI = 1.18-4.57) models. For ALDH2 rs671, the AA genotype was correlated with an increased risk of Alzheimer's disease as compared to the GG genotype (OR = 4.57, 95%CI = 1.60-14.01). The ALDH2 rs671 polymorphism was associated with Alzheimer's in both dominant (OR = 1.79, 95%CI = 1.08-2.97) and recessive (OR = 4.17, 95%CI = 1.49-12.67) models. In conclusion, we observed that ADH1B rs1229984 and ALDH2 rs671 polymorphisms increased the risk of Alzheimer's disease in all the genetic models.
doi_str_mv	10.4238/gmr.15048740
format	Article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1837317591</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1836735359</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4130-58f6c80d4629f0d1356017212380a43bc8fc9909592ef3f801e42dc663a911cc3</originalsourceid><addsrcrecordid>eNqNkU1Lw0AQhhdRbK3ePMve9GDqzn5l91hbtUJBED2HdDNpI_lytxXqrzfaVjx6mmF4eOGdh5BzYEPJhblZVH4IikkTS3ZA-qBjHSlt2OGfvUdOQnhjjCtp2DHp8dgwI2LeJ9lzUyJtcjqaTOGW-gCcW2skTeuMjmaTKe9uOga6wBpp25SbqvHtsghVoEVNV0ukGX5g2bQV1qufoPJziUWF_jLQrAiYBjwlR3laBjzbzQF5vb97GU-j2dPD43g0i5wEwSJlcu0My6TmNmcZCKUZxBy6liyVYu5M7qxlVlmOucgNA5Q8c1qL1AI4Jwbkapvb-uZ9jWGVVEVwWJZpjc06JNB1FhArC_9BdSyUULZDr7eo800IHvOk9UWV-k0CLPlWkHQKkr2CDr_YJa_nFWa_8P7n4guxFX05</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1836735359</pqid></control><display><type>article</type><title>Role of ADH1B rs1229984 and ALDH2 rs671 gene polymorphisms in the development of Alzheimer's disease</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Ma, L ; Lu, Z N</creator><creatorcontrib>Ma, L ; Lu, Z N</creatorcontrib><description>In the present study, we investigated the association between ADH1B rs1229984 and ALDH2 rs671 polymorphisms and the development of Alzheimer's disease in a Chinese population. Genotyping of the ADH1B rs1229984 and ALDH2 rs671 polymorphisms was carried out by polymerase chain reaction-restriction fragment length polymorphism. Logistic regression analyses revealed that the AA genotype of ADH1B rs1229984 was associated with an increased risk of Alzheimer's disease (OR = 2.54, 95%CI = 1.19-5.41). In addition, ADH1B rs1229984 was also associated with elevated risk of Alzheimer's disease in both dominant (OR = 1.78, 95%CI = 1.09-2.93) and recessive (OR = 2.33, 95%CI = 1.18-4.57) models. For ALDH2 rs671, the AA genotype was correlated with an increased risk of Alzheimer's disease as compared to the GG genotype (OR = 4.57, 95%CI = 1.60-14.01). The ALDH2 rs671 polymorphism was associated with Alzheimer's in both dominant (OR = 1.79, 95%CI = 1.08-2.97) and recessive (OR = 4.17, 95%CI = 1.49-12.67) models. In conclusion, we observed that ADH1B rs1229984 and ALDH2 rs671 polymorphisms increased the risk of Alzheimer's disease in all the genetic models.</description><identifier>ISSN: 1676-5680</identifier><identifier>EISSN: 1676-5680</identifier><identifier>DOI: 10.4238/gmr.15048740</identifier><identifier>PMID: 27808372</identifier><language>eng</language><publisher>Brazil</publisher><subject>Aged ; Alcohol Dehydrogenase - genetics ; Alcohol Drinking - adverse effects ; Aldehyde Dehydrogenase, Mitochondrial - genetics ; Alzheimer Disease - genetics ; Case-Control Studies ; Demography ; Epistasis, Genetic ; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Polymorphism, Single Nucleotide - genetics ; Risk Factors</subject><ispartof>Genetics and molecular research, 2016-10, Vol.15 (4)</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4130-58f6c80d4629f0d1356017212380a43bc8fc9909592ef3f801e42dc663a911cc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27808372$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, L</creatorcontrib><creatorcontrib>Lu, Z N</creatorcontrib><title>Role of ADH1B rs1229984 and ALDH2 rs671 gene polymorphisms in the development of Alzheimer's disease</title><title>Genetics and molecular research</title><addtitle>Genet Mol Res</addtitle><description>In the present study, we investigated the association between ADH1B rs1229984 and ALDH2 rs671 polymorphisms and the development of Alzheimer's disease in a Chinese population. Genotyping of the ADH1B rs1229984 and ALDH2 rs671 polymorphisms was carried out by polymerase chain reaction-restriction fragment length polymorphism. Logistic regression analyses revealed that the AA genotype of ADH1B rs1229984 was associated with an increased risk of Alzheimer's disease (OR = 2.54, 95%CI = 1.19-5.41). In addition, ADH1B rs1229984 was also associated with elevated risk of Alzheimer's disease in both dominant (OR = 1.78, 95%CI = 1.09-2.93) and recessive (OR = 2.33, 95%CI = 1.18-4.57) models. For ALDH2 rs671, the AA genotype was correlated with an increased risk of Alzheimer's disease as compared to the GG genotype (OR = 4.57, 95%CI = 1.60-14.01). The ALDH2 rs671 polymorphism was associated with Alzheimer's in both dominant (OR = 1.79, 95%CI = 1.08-2.97) and recessive (OR = 4.17, 95%CI = 1.49-12.67) models. In conclusion, we observed that ADH1B rs1229984 and ALDH2 rs671 polymorphisms increased the risk of Alzheimer's disease in all the genetic models.</description><subject>Aged</subject><subject>Alcohol Dehydrogenase - genetics</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Aldehyde Dehydrogenase, Mitochondrial - genetics</subject><subject>Alzheimer Disease - genetics</subject><subject>Case-Control Studies</subject><subject>Demography</subject><subject>Epistasis, Genetic</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Male</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Risk Factors</subject><issn>1676-5680</issn><issn>1676-5680</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1Lw0AQhhdRbK3ePMve9GDqzn5l91hbtUJBED2HdDNpI_lytxXqrzfaVjx6mmF4eOGdh5BzYEPJhblZVH4IikkTS3ZA-qBjHSlt2OGfvUdOQnhjjCtp2DHp8dgwI2LeJ9lzUyJtcjqaTOGW-gCcW2skTeuMjmaTKe9uOga6wBpp25SbqvHtsghVoEVNV0ukGX5g2bQV1qufoPJziUWF_jLQrAiYBjwlR3laBjzbzQF5vb97GU-j2dPD43g0i5wEwSJlcu0My6TmNmcZCKUZxBy6liyVYu5M7qxlVlmOucgNA5Q8c1qL1AI4Jwbkapvb-uZ9jWGVVEVwWJZpjc06JNB1FhArC_9BdSyUULZDr7eo800IHvOk9UWV-k0CLPlWkHQKkr2CDr_YJa_nFWa_8P7n4guxFX05</recordid><startdate>20161005</startdate><enddate>20161005</enddate><creator>Ma, L</creator><creator>Lu, Z N</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20161005</creationdate><title>Role of ADH1B rs1229984 and ALDH2 rs671 gene polymorphisms in the development of Alzheimer's disease</title><author>Ma, L ; Lu, Z N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4130-58f6c80d4629f0d1356017212380a43bc8fc9909592ef3f801e42dc663a911cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Alcohol Dehydrogenase - genetics</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Aldehyde Dehydrogenase, Mitochondrial - genetics</topic><topic>Alzheimer Disease - genetics</topic><topic>Case-Control Studies</topic><topic>Demography</topic><topic>Epistasis, Genetic</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Male</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, L</creatorcontrib><creatorcontrib>Lu, Z N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Genetics and molecular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, L</au><au>Lu, Z N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of ADH1B rs1229984 and ALDH2 rs671 gene polymorphisms in the development of Alzheimer's disease</atitle><jtitle>Genetics and molecular research</jtitle><addtitle>Genet Mol Res</addtitle><date>2016-10-05</date><risdate>2016</risdate><volume>15</volume><issue>4</issue><issn>1676-5680</issn><eissn>1676-5680</eissn><abstract>In the present study, we investigated the association between ADH1B rs1229984 and ALDH2 rs671 polymorphisms and the development of Alzheimer's disease in a Chinese population. Genotyping of the ADH1B rs1229984 and ALDH2 rs671 polymorphisms was carried out by polymerase chain reaction-restriction fragment length polymorphism. Logistic regression analyses revealed that the AA genotype of ADH1B rs1229984 was associated with an increased risk of Alzheimer's disease (OR = 2.54, 95%CI = 1.19-5.41). In addition, ADH1B rs1229984 was also associated with elevated risk of Alzheimer's disease in both dominant (OR = 1.78, 95%CI = 1.09-2.93) and recessive (OR = 2.33, 95%CI = 1.18-4.57) models. For ALDH2 rs671, the AA genotype was correlated with an increased risk of Alzheimer's disease as compared to the GG genotype (OR = 4.57, 95%CI = 1.60-14.01). The ALDH2 rs671 polymorphism was associated with Alzheimer's in both dominant (OR = 1.79, 95%CI = 1.08-2.97) and recessive (OR = 4.17, 95%CI = 1.49-12.67) models. In conclusion, we observed that ADH1B rs1229984 and ALDH2 rs671 polymorphisms increased the risk of Alzheimer's disease in all the genetic models.</abstract><cop>Brazil</cop><pmid>27808372</pmid><doi>10.4238/gmr.15048740</doi><oa>free_for_read</oa></addata></record>
fulltext	fulltext
identifier	ISSN: 1676-5680
ispartof	Genetics and molecular research, 2016-10, Vol.15 (4)
issn	1676-5680 1676-5680
language	eng
recordid	cdi_proquest_miscellaneous_1837317591
source	MEDLINE; EZB-FREE-00999 freely available EZB journals
subjects	Aged Alcohol Dehydrogenase - genetics Alcohol Drinking - adverse effects Aldehyde Dehydrogenase, Mitochondrial - genetics Alzheimer Disease - genetics Case-Control Studies Demography Epistasis, Genetic Female Genetic Predisposition to Disease Humans Male Polymorphism, Single Nucleotide - genetics Risk Factors
title	Role of ADH1B rs1229984 and ALDH2 rs671 gene polymorphisms in the development of Alzheimer's disease
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T00%3A41%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20ADH1B%20rs1229984%20and%20ALDH2%20rs671%20gene%20polymorphisms%20in%20the%20development%20of%20Alzheimer's%20disease&rft.jtitle=Genetics%20and%20molecular%20research&rft.au=Ma,%20L&rft.date=2016-10-05&rft.volume=15&rft.issue=4&rft.issn=1676-5680&rft.eissn=1676-5680&rft_id=info:doi/10.4238/gmr.15048740&rft_dat=%3Cproquest_cross%3E1836735359%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1836735359&rft_id=info:pmid/27808372&rfr_iscdi=true