Hot-Melt Granulation in a Twin Screw Extruder: Effects of Processing on Formulations with Caffeine and Ibuprofen

Hot-melt granulation (HMG) by twin screw extrusion is a novel technology for the continuous processing of pharmaceuticals but confidence must still be gained regarding whether the environment affects drug properties. In this preliminary study, granulation was studied for a model product containing l...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2013-12, Vol.102 (12), p.4330-4336
Hauptverfasser:	Weatherley, Sharleen, MU, B.O., Thompson, Michael R., Sheskey, Paul J., O'Donnell, Kevin P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - chemistry caffeine Caffeine - chemistry calorimetry (DSC) chemical stability continuous granulation Drug Compounding - instrumentation drug degradation Drug Stability extrusion granulation Hot Temperature hot-melt granulation ibuprofen Ibuprofen - chemistry Lactose - chemistry Particle Size Solubility X-Ray Diffraction X-ray diffractometry
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