Endothelin receptors in augmented vasoconstrictor responses to endothelin-1 in chronic intermittent hypoxia

Summary Chronic intermittent hypoxia (CIH) contributes to the development of cardiovascular diseases in patients with obstructive sleep apnoea. Many studies have shown an association between increased circulating endothelin (ET)‐1 levels and CIH. The aim of the present study was to determine the rol...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 2013-07, Vol.40 (7), p.449-457
Hauptverfasser:	Guo, Qiu-Hong, Tian, Yi-Long, Wang, Zhuo, Li, Ai-Ying, Ma, Zhi-Hong, Guo, Ya-Jing, Weiss, J Woodrow, Ji, En-Sheng, Chu, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals aorta Aorta - metabolism Aorta - physiopathology chronic intermittent hypoxia Disease Models, Animal Endothelin A Receptor Antagonists Endothelin B Receptor Antagonists endothelin receptors endothelin-1 Endothelin-1 - genetics Endothelin-1 - metabolism Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Hypoxia - genetics Hypoxia - metabolism Hypoxia - physiopathology Male Nitric Oxide - genetics Nitric Oxide - metabolism Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism Rats Rats, Sprague-Dawley Receptor, Endothelin A - genetics Receptor, Endothelin A - metabolism Receptor, Endothelin B - genetics Receptor, Endothelin B - metabolism Vasoconstriction - genetics Vasoconstriction - physiology Vasodilation - genetics Vasodilation - physiology
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