Sex-dependent association between angiotensin-converting enzyme insertion/deletion polymorphism and obesity in relation to sodium intake in children
Abstract Objective Obesity is a complex condition that is influenced by genetic and environmental factors and is associated with an increased risk for diabetes, hypertension, and cardiovascular diseases. Angiotensin-converting enzyme (ACE) is well characterized in the control of blood pressure. This...
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| Veröffentlicht in: | Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2013-03, Vol.29 (3), p.525-530 |
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| creator | Yang, Soo Jin, Ph.D Kim, Sunyoung, M.S Park, Hyesoon, M.D Kim, Seon-Mee, M.D Choi, Kyung-Mook, M.D Lim, Yunsook, Ph.D Lee, Myoungsook, Ph.D |
| description | Abstract Objective Obesity is a complex condition that is influenced by genetic and environmental factors and is associated with an increased risk for diabetes, hypertension, and cardiovascular diseases. Angiotensin-converting enzyme (ACE) is well characterized in the control of blood pressure. This study investigated whether the ACE insertion/deletion (I/D) polymorphism affects obesity in relation to sodium intake in children. Methods A cross-sectional study was conducted in 1260 elementary schoolchildren (633 boys and 627 girls). Subjects were assessed for the degree of obesity, sodium intake, and ACE I/D genotype, and associations were evaluated between the ACE I/D polymorphism and obesity in relation to sodium intake. Results Sodium intake was significantly correlated with the obesity index ( r = 0.048, P = 0.016) and was particularly high in obese D-carrier boys compared with normal D-carrier boys. D-carrier boys did not show any association with the degree of obesity, whereas D-carrier girls with a high sodium intake exhibited a significant association (odds ratio 0.551, P = 0.042) and a negative correlation between the D allele and obesity as a continuous variable (regression coefficient −3.095, P = 0.020), showing gender-dependent associations between the ACE I/D polymorphism and obesity in relation to sodium intake. Conclusions These findings demonstrate that the association between the ACE I/D polymorphism and obesity in relation to sodium intake is gender dependent in children. |
| doi_str_mv | 10.1016/j.nut.2012.09.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1837316340</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0899900712003553</els_id><sourcerecordid>1837316340</sourcerecordid><originalsourceid>FETCH-LOGICAL-c499t-df9ee4477793dd2987ce7e22d21b7f19fe43fd1b0ca75bb1a8515c3122e4738f3</originalsourceid><addsrcrecordid>eNqFks1u1TAQhS0EopfCA7BBkRASm6T-SeJYSJVQxZ9UiUVhbTn2pPVtYl9spxCegwfG6b1QqQtYWRp954xnziD0nOCKYNKebCs3p4piQissKozJA7QhHWcloXX9EG1wJ0QpMOZH6EmMW5wJ0YrH6IgyJjpB8Qb9uoAfpYEdOAMuFSpGr61K1ruih_QdwBXKXVqfwEXrSu3dDYRk3WUB7ucyQWFdXAvenRgY4Va48-My-bC7snHKalP4HqJNS2aLAOPePfkiemPnKVeTul6NCn1lRxPAPUWPBjVGeHZ4j9HX9---nH0szz9_-HT29rzUtRCpNIMAqGvOuWDGUNFxDRwoNZT0fCBigJoNhvRYK970PVFdQxrNCKVQc9YN7Bi93vvugv82Q0xyslHDOCoHfo6SdIwz0rIa_x-lee9d3ivJ6Mt76NbPweVBbilcN21bZ4rsKR18jAEGuQt2UmGRBMs1XbmVOV25piuxkDm7rHlxcJ77CcxfxZ84M_DqAKio1TgE5bSNdxwntBFUZO7NnoO83RsLQUZtwWkwNoBO0nj7z2-c3lPr0TqbG17DAvFuWhmzRl6sZ7heIaEYs6Zh7DdKeNpA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1287045664</pqid></control><display><type>article</type><title>Sex-dependent association between angiotensin-converting enzyme insertion/deletion polymorphism and obesity in relation to sodium intake in children</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>ProQuest Central UK/Ireland</source><creator>Yang, Soo Jin, Ph.D ; Kim, Sunyoung, M.S ; Park, Hyesoon, M.D ; Kim, Seon-Mee, M.D ; Choi, Kyung-Mook, M.D ; Lim, Yunsook, Ph.D ; Lee, Myoungsook, Ph.D</creator><creatorcontrib>Yang, Soo Jin, Ph.D ; Kim, Sunyoung, M.S ; Park, Hyesoon, M.D ; Kim, Seon-Mee, M.D ; Choi, Kyung-Mook, M.D ; Lim, Yunsook, Ph.D ; Lee, Myoungsook, Ph.D</creatorcontrib><description>Abstract Objective Obesity is a complex condition that is influenced by genetic and environmental factors and is associated with an increased risk for diabetes, hypertension, and cardiovascular diseases. Angiotensin-converting enzyme (ACE) is well characterized in the control of blood pressure. This study investigated whether the ACE insertion/deletion (I/D) polymorphism affects obesity in relation to sodium intake in children. Methods A cross-sectional study was conducted in 1260 elementary schoolchildren (633 boys and 627 girls). Subjects were assessed for the degree of obesity, sodium intake, and ACE I/D genotype, and associations were evaluated between the ACE I/D polymorphism and obesity in relation to sodium intake. Results Sodium intake was significantly correlated with the obesity index ( r = 0.048, P = 0.016) and was particularly high in obese D-carrier boys compared with normal D-carrier boys. D-carrier boys did not show any association with the degree of obesity, whereas D-carrier girls with a high sodium intake exhibited a significant association (odds ratio 0.551, P = 0.042) and a negative correlation between the D allele and obesity as a continuous variable (regression coefficient −3.095, P = 0.020), showing gender-dependent associations between the ACE I/D polymorphism and obesity in relation to sodium intake. Conclusions These findings demonstrate that the association between the ACE I/D polymorphism and obesity in relation to sodium intake is gender dependent in children.</description><identifier>ISSN: 0899-9007</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2012.09.001</identifier><identifier>PMID: 23398920</identifier><identifier>CODEN: NUTRER</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adiposity ; Angiotensin-converting enzyme insertion/deletion polymorphism ; Biological and medical sciences ; Blood Pressure ; Body Mass Index ; Cardiovascular diseases ; Child ; Children ; Children & youth ; Cholesterol ; Cross-Sectional Studies ; Diet ; Environmental factors ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology and Hepatology ; Gender-dependent association ; Gene Deletion ; Gene Frequency ; Genotype ; Heterozygote ; Humans ; Hypertension ; Male ; Medical sciences ; Metabolic diseases ; Metabolic disorders ; Mutagenesis, Insertional ; Obesity ; Obesity - enzymology ; Obesity - genetics ; Peptidyl-Dipeptidase A - genetics ; Polymorphism, Genetic - genetics ; Republic of Korea ; Sex Factors ; Sodium ; Sodium intake ; Sodium, Dietary - administration & dosage ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Waist Circumference</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2013-03, Vol.29 (3), p.525-530</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-df9ee4477793dd2987ce7e22d21b7f19fe43fd1b0ca75bb1a8515c3122e4738f3</citedby><cites>FETCH-LOGICAL-c499t-df9ee4477793dd2987ce7e22d21b7f19fe43fd1b0ca75bb1a8515c3122e4738f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1287045664?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,64361,64363,64365,65309,72215</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27125929$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23398920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Soo Jin, Ph.D</creatorcontrib><creatorcontrib>Kim, Sunyoung, M.S</creatorcontrib><creatorcontrib>Park, Hyesoon, M.D</creatorcontrib><creatorcontrib>Kim, Seon-Mee, M.D</creatorcontrib><creatorcontrib>Choi, Kyung-Mook, M.D</creatorcontrib><creatorcontrib>Lim, Yunsook, Ph.D</creatorcontrib><creatorcontrib>Lee, Myoungsook, Ph.D</creatorcontrib><title>Sex-dependent association between angiotensin-converting enzyme insertion/deletion polymorphism and obesity in relation to sodium intake in children</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><addtitle>Nutrition</addtitle><description>Abstract Objective Obesity is a complex condition that is influenced by genetic and environmental factors and is associated with an increased risk for diabetes, hypertension, and cardiovascular diseases. Angiotensin-converting enzyme (ACE) is well characterized in the control of blood pressure. This study investigated whether the ACE insertion/deletion (I/D) polymorphism affects obesity in relation to sodium intake in children. Methods A cross-sectional study was conducted in 1260 elementary schoolchildren (633 boys and 627 girls). Subjects were assessed for the degree of obesity, sodium intake, and ACE I/D genotype, and associations were evaluated between the ACE I/D polymorphism and obesity in relation to sodium intake. Results Sodium intake was significantly correlated with the obesity index ( r = 0.048, P = 0.016) and was particularly high in obese D-carrier boys compared with normal D-carrier boys. D-carrier boys did not show any association with the degree of obesity, whereas D-carrier girls with a high sodium intake exhibited a significant association (odds ratio 0.551, P = 0.042) and a negative correlation between the D allele and obesity as a continuous variable (regression coefficient −3.095, P = 0.020), showing gender-dependent associations between the ACE I/D polymorphism and obesity in relation to sodium intake. Conclusions These findings demonstrate that the association between the ACE I/D polymorphism and obesity in relation to sodium intake is gender dependent in children.</description><subject>Adiposity</subject><subject>Angiotensin-converting enzyme insertion/deletion polymorphism</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Body Mass Index</subject><subject>Cardiovascular diseases</subject><subject>Child</subject><subject>Children</subject><subject>Children & youth</subject><subject>Cholesterol</subject><subject>Cross-Sectional Studies</subject><subject>Diet</subject><subject>Environmental factors</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology and Hepatology</subject><subject>Gender-dependent association</subject><subject>Gene Deletion</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Heterozygote</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metabolic disorders</subject><subject>Mutagenesis, Insertional</subject><subject>Obesity</subject><subject>Obesity - enzymology</subject><subject>Obesity - genetics</subject><subject>Peptidyl-Dipeptidase A - genetics</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Republic of Korea</subject><subject>Sex Factors</subject><subject>Sodium</subject><subject>Sodium intake</subject><subject>Sodium, Dietary - administration & dosage</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Waist Circumference</subject><issn>0899-9007</issn><issn>1873-1244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFks1u1TAQhS0EopfCA7BBkRASm6T-SeJYSJVQxZ9UiUVhbTn2pPVtYl9spxCegwfG6b1QqQtYWRp954xnziD0nOCKYNKebCs3p4piQissKozJA7QhHWcloXX9EG1wJ0QpMOZH6EmMW5wJ0YrH6IgyJjpB8Qb9uoAfpYEdOAMuFSpGr61K1ruih_QdwBXKXVqfwEXrSu3dDYRk3WUB7ucyQWFdXAvenRgY4Va48-My-bC7snHKalP4HqJNS2aLAOPePfkiemPnKVeTul6NCn1lRxPAPUWPBjVGeHZ4j9HX9---nH0szz9_-HT29rzUtRCpNIMAqGvOuWDGUNFxDRwoNZT0fCBigJoNhvRYK970PVFdQxrNCKVQc9YN7Bi93vvugv82Q0xyslHDOCoHfo6SdIwz0rIa_x-lee9d3ivJ6Mt76NbPweVBbilcN21bZ4rsKR18jAEGuQt2UmGRBMs1XbmVOV25piuxkDm7rHlxcJ77CcxfxZ84M_DqAKio1TgE5bSNdxwntBFUZO7NnoO83RsLQUZtwWkwNoBO0nj7z2-c3lPr0TqbG17DAvFuWhmzRl6sZ7heIaEYs6Zh7DdKeNpA</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Yang, Soo Jin, Ph.D</creator><creator>Kim, Sunyoung, M.S</creator><creator>Park, Hyesoon, M.D</creator><creator>Kim, Seon-Mee, M.D</creator><creator>Choi, Kyung-Mook, M.D</creator><creator>Lim, Yunsook, Ph.D</creator><creator>Lee, Myoungsook, Ph.D</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20130301</creationdate><title>Sex-dependent association between angiotensin-converting enzyme insertion/deletion polymorphism and obesity in relation to sodium intake in children</title><author>Yang, Soo Jin, Ph.D ; Kim, Sunyoung, M.S ; Park, Hyesoon, M.D ; Kim, Seon-Mee, M.D ; Choi, Kyung-Mook, M.D ; Lim, Yunsook, Ph.D ; Lee, Myoungsook, Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-df9ee4477793dd2987ce7e22d21b7f19fe43fd1b0ca75bb1a8515c3122e4738f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adiposity</topic><topic>Angiotensin-converting enzyme insertion/deletion polymorphism</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Body Mass Index</topic><topic>Cardiovascular diseases</topic><topic>Child</topic><topic>Children</topic><topic>Children & youth</topic><topic>Cholesterol</topic><topic>Cross-Sectional Studies</topic><topic>Diet</topic><topic>Environmental factors</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology and Hepatology</topic><topic>Gender-dependent association</topic><topic>Gene Deletion</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Heterozygote</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metabolic disorders</topic><topic>Mutagenesis, Insertional</topic><topic>Obesity</topic><topic>Obesity - enzymology</topic><topic>Obesity - genetics</topic><topic>Peptidyl-Dipeptidase A - genetics</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Republic of Korea</topic><topic>Sex Factors</topic><topic>Sodium</topic><topic>Sodium intake</topic><topic>Sodium, Dietary - administration & dosage</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Waist Circumference</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Soo Jin, Ph.D</creatorcontrib><creatorcontrib>Kim, Sunyoung, M.S</creatorcontrib><creatorcontrib>Park, Hyesoon, M.D</creatorcontrib><creatorcontrib>Kim, Seon-Mee, M.D</creatorcontrib><creatorcontrib>Choi, Kyung-Mook, M.D</creatorcontrib><creatorcontrib>Lim, Yunsook, Ph.D</creatorcontrib><creatorcontrib>Lee, Myoungsook, Ph.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Soo Jin, Ph.D</au><au>Kim, Sunyoung, M.S</au><au>Park, Hyesoon, M.D</au><au>Kim, Seon-Mee, M.D</au><au>Choi, Kyung-Mook, M.D</au><au>Lim, Yunsook, Ph.D</au><au>Lee, Myoungsook, Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex-dependent association between angiotensin-converting enzyme insertion/deletion polymorphism and obesity in relation to sodium intake in children</atitle><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle><addtitle>Nutrition</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>29</volume><issue>3</issue><spage>525</spage><epage>530</epage><pages>525-530</pages><issn>0899-9007</issn><eissn>1873-1244</eissn><coden>NUTRER</coden><abstract>Abstract Objective Obesity is a complex condition that is influenced by genetic and environmental factors and is associated with an increased risk for diabetes, hypertension, and cardiovascular diseases. Angiotensin-converting enzyme (ACE) is well characterized in the control of blood pressure. This study investigated whether the ACE insertion/deletion (I/D) polymorphism affects obesity in relation to sodium intake in children. Methods A cross-sectional study was conducted in 1260 elementary schoolchildren (633 boys and 627 girls). Subjects were assessed for the degree of obesity, sodium intake, and ACE I/D genotype, and associations were evaluated between the ACE I/D polymorphism and obesity in relation to sodium intake. Results Sodium intake was significantly correlated with the obesity index ( r = 0.048, P = 0.016) and was particularly high in obese D-carrier boys compared with normal D-carrier boys. D-carrier boys did not show any association with the degree of obesity, whereas D-carrier girls with a high sodium intake exhibited a significant association (odds ratio 0.551, P = 0.042) and a negative correlation between the D allele and obesity as a continuous variable (regression coefficient −3.095, P = 0.020), showing gender-dependent associations between the ACE I/D polymorphism and obesity in relation to sodium intake. Conclusions These findings demonstrate that the association between the ACE I/D polymorphism and obesity in relation to sodium intake is gender dependent in children.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>23398920</pmid><doi>10.1016/j.nut.2012.09.001</doi><tpages>6</tpages></addata></record> |
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| subjects | Adiposity Angiotensin-converting enzyme insertion/deletion polymorphism Biological and medical sciences Blood Pressure Body Mass Index Cardiovascular diseases Child Children Children & youth Cholesterol Cross-Sectional Studies Diet Environmental factors Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastroenterology and Hepatology Gender-dependent association Gene Deletion Gene Frequency Genotype Heterozygote Humans Hypertension Male Medical sciences Metabolic diseases Metabolic disorders Mutagenesis, Insertional Obesity Obesity - enzymology Obesity - genetics Peptidyl-Dipeptidase A - genetics Polymorphism, Genetic - genetics Republic of Korea Sex Factors Sodium Sodium intake Sodium, Dietary - administration & dosage Vertebrates: anatomy and physiology, studies on body, several organs or systems Waist Circumference |
| title | Sex-dependent association between angiotensin-converting enzyme insertion/deletion polymorphism and obesity in relation to sodium intake in children |
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