Marek’s disease herpesvirus vaccines integrate into chicken host chromosomes yet lack a virus-host phenotype associated with oncogenic transformation
Highlights • Marek’s disease (MD) incidence is reduced with HVT, SB-1, and/or Rispens vaccination. • The physical status of MD vaccines at the level of the host genome was not known. • We provide an overview of the cytogenetic interactions of MD vaccines with the host. • Our data show that MD vaccin...
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| Veröffentlicht in: | Vaccine 2016-11, Vol.34 (46), p.5554-5561 |
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| container_title | Vaccine |
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| creator | McPherson, Marla C Cheng, Hans H Delany, Mary E |
| description | Highlights • Marek’s disease (MD) incidence is reduced with HVT, SB-1, and/or Rispens vaccination. • The physical status of MD vaccines at the level of the host genome was not known. • We provide an overview of the cytogenetic interactions of MD vaccines with the host. • Our data show that MD vaccines are capable of integrating into the host genome. • However, MD vaccines lacked a virus-host phenotype observed for oncogenic MDV. |
| doi_str_mv | 10.1016/j.vaccine.2016.09.051 |
| format | Article |
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| subjects | Allergy and Immunology Alphaherpesvirinae Alphaherpesvirus Animals antineoplastic activity Artificial chromosomes biosecurity Birds Cell Transformation, Viral - genetics Chicken Chickens Chickens - genetics Chromosomes Chromosomes - genetics Cytogenetics death disease resistance Experiments flocks genetic resistance Genome Genomes Genotype & phenotype Herpesviridae Herpesvirus 2, Gallid - genetics Herpesvirus 2, Gallid - physiology host-pathogen relationships hosts Hypotheses immunity Infections Laboratory animals Lymphocytes Lymphoma Marek disease Marek Disease - prevention & control Marek Disease Vaccines - genetics Marek Disease Vaccines - immunology Marek’s disease virus Methods oncogenic viruses Oncogenic Viruses - genetics Oncogenic Viruses - physiology pathogens Phenotype Poultry Diseases - prevention & control R&D Research & development Science selection methods Selective breeding Serogroup serotypes Spleen Telomerase telomeres vaccination Vaccine Vaccines Viral integration Viral Vaccines - genetics Virus Integration virus replication Viruses |
| title | Marek’s disease herpesvirus vaccines integrate into chicken host chromosomes yet lack a virus-host phenotype associated with oncogenic transformation |
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