Osteosarcoma in Asian Populations Over the Age of 40 Years: A Multicenter Study
Background Elderly patients with osteosarcoma (OSA) are no longer uncommon; however, many questions remain regarding this population. We investigated the clinicopathological characteristics and prognostic factors of OSA in an Asian population over the age of 40 years. Methods This was a multi-nation...
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| Veröffentlicht in: | Annals of surgical oncology 2015-10, Vol.22 (11), p.3557-3564 |
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| creator | Joo, Min Wook Shin, Seung Han Kang, Yong-Koo Kawai, Akira Kim, Han Soo Asavamongkolkul, Apichat Jeon, Dae-Geun Kim, Jae Do Niu, Xiaohui Tsuchiya, Hiroyuki Puri, Ajay Wang, Edward H. M. Chung, So Hak Chung, Yang-Guk |
| description | Background
Elderly patients with osteosarcoma (OSA) are no longer uncommon; however, many questions remain regarding this population. We investigated the clinicopathological characteristics and prognostic factors of OSA in an Asian population over the age of 40 years.
Methods
This was a multi-national, multi-institutional study by the Eastern Asian Musculoskeletal Oncology Group (EAMOG).
Results
A total of 232 patients were enrolled (116 males and 116 females), with a median age of 50 years at diagnosis; 25 (10.8 %) patients exhibited initial metastasis. Median follow-up was 52 months for survivors. We observed 102 osteolytic and mixed radiographic findings for 173 lesions. Histological subtypes other than osteoblastic type were frequent. Radiation-associated OSA was seen in seven patients, with a 5-year overall survival (OS) of 16.7 %. No Paget’s OSA was observed. High-grade spinopelvic OSA was seen in 29 (12.5 %) patients. The 5-year OS was 59.4 % in patients without initial metastasis and 45.2 % in patients with spinopelvic OSA. While surgery and initial metastasis were common prognostic factors for OS, chemotherapy was not. Histologic response to neoadjuvant chemotherapy was poor in 61 of 83 patients.
Conclusion
This study revealed distinct clinicopathological features of OSA patients over 40 years of age compared with younger patients, such as the high incidence of axial tumors, common osteolytic and mixed radiographic findings, the high frequency of unusual histologic subtypes, and poor prognosis. Contrary to Western elderly patients with OSA, there was no Paget’s OSA in this study, which may result in a lower incidence of secondary OSA. Prognostic factor analyses demonstrated chemotherapy did not influence OS. |
| doi_str_mv | 10.1245/s10434-015-4414-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1837314651</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1711546733</sourcerecordid><originalsourceid>FETCH-LOGICAL-c541t-8761a4dfcad4748ba11b1f4d8b52ff1c9518bd98228d26dc6debd292936096863</originalsourceid><addsrcrecordid>eNqFkU1LxDAQhoMorl8_wIsEvHipZvLV1Nuy-AXKCurBU0ibdK10mzVphf33ZlkVEcRThswz7zA8CB0COQXKxVkEwhnPCIiMc-CZ3EA7INIPlwo2U02kygoqxQjtxvhKCOSMiG00okLmUnG2g6bT2DsfTaj83OCmw-PYmA7f-8XQmr7xXcTTdxdw_-LweOawrzEn-NmZEM_xGN8Nbd9UrusT8tAPdrmPtmrTRnfw-e6hp8uLx8l1dju9upmMb7NKcOgzlUsw3NaVsTznqjQAJdTcqlLQuoaqEKBKWyhKlaXSVtK60tKCFkySQirJ9tDJOncR_NvgYq_nTaxc25rO-SFqUCxnwKWA_9EcQHCZM5bQ41_oqx9Clw5JgVSBzFWx2g1rqgo-xuBqvQjN3ISlBqJXYvRajE5i9EqMXs0cfSYP5dzZ74kvEwmgayCmVjdz4cfqP1M_ALE6lY0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1828167896</pqid></control><display><type>article</type><title>Osteosarcoma in Asian Populations Over the Age of 40 Years: A Multicenter Study</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Joo, Min Wook ; Shin, Seung Han ; Kang, Yong-Koo ; Kawai, Akira ; Kim, Han Soo ; Asavamongkolkul, Apichat ; Jeon, Dae-Geun ; Kim, Jae Do ; Niu, Xiaohui ; Tsuchiya, Hiroyuki ; Puri, Ajay ; Wang, Edward H. M. ; Chung, So Hak ; Chung, Yang-Guk</creator><creatorcontrib>Joo, Min Wook ; Shin, Seung Han ; Kang, Yong-Koo ; Kawai, Akira ; Kim, Han Soo ; Asavamongkolkul, Apichat ; Jeon, Dae-Geun ; Kim, Jae Do ; Niu, Xiaohui ; Tsuchiya, Hiroyuki ; Puri, Ajay ; Wang, Edward H. M. ; Chung, So Hak ; Chung, Yang-Guk</creatorcontrib><description>Background
Elderly patients with osteosarcoma (OSA) are no longer uncommon; however, many questions remain regarding this population. We investigated the clinicopathological characteristics and prognostic factors of OSA in an Asian population over the age of 40 years.
Methods
This was a multi-national, multi-institutional study by the Eastern Asian Musculoskeletal Oncology Group (EAMOG).
Results
A total of 232 patients were enrolled (116 males and 116 females), with a median age of 50 years at diagnosis; 25 (10.8 %) patients exhibited initial metastasis. Median follow-up was 52 months for survivors. We observed 102 osteolytic and mixed radiographic findings for 173 lesions. Histological subtypes other than osteoblastic type were frequent. Radiation-associated OSA was seen in seven patients, with a 5-year overall survival (OS) of 16.7 %. No Paget’s OSA was observed. High-grade spinopelvic OSA was seen in 29 (12.5 %) patients. The 5-year OS was 59.4 % in patients without initial metastasis and 45.2 % in patients with spinopelvic OSA. While surgery and initial metastasis were common prognostic factors for OS, chemotherapy was not. Histologic response to neoadjuvant chemotherapy was poor in 61 of 83 patients.
Conclusion
This study revealed distinct clinicopathological features of OSA patients over 40 years of age compared with younger patients, such as the high incidence of axial tumors, common osteolytic and mixed radiographic findings, the high frequency of unusual histologic subtypes, and poor prognosis. Contrary to Western elderly patients with OSA, there was no Paget’s OSA in this study, which may result in a lower incidence of secondary OSA. Prognostic factor analyses demonstrated chemotherapy did not influence OS.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-015-4414-6</identifier><identifier>PMID: 25676843</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Antineoplastic Agents - therapeutic use ; Asian Continental Ancestry Group ; Bone and Bones ; Bone and Soft Tissue Sarcomas ; Bone Neoplasms - drug therapy ; Bone Neoplasms - pathology ; Bone Neoplasms - surgery ; Chemotherapy, Adjuvant ; Female ; Femur ; Follow-Up Studies ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoadjuvant Therapy ; Neoplasm Grading ; Neoplasms, Radiation-Induced - drug therapy ; Neoplasms, Radiation-Induced - pathology ; Neoplasms, Radiation-Induced - surgery ; Oncology ; Osteosarcoma - drug therapy ; Osteosarcoma - secondary ; Osteosarcoma - surgery ; Pelvic Bones ; Prognosis ; Retrospective Studies ; Sacrum ; Spinal Neoplasms - drug therapy ; Spinal Neoplasms - pathology ; Spinal Neoplasms - surgery ; Surgery ; Surgical Oncology ; Survival Rate ; Tibia</subject><ispartof>Annals of surgical oncology, 2015-10, Vol.22 (11), p.3557-3564</ispartof><rights>Society of Surgical Oncology 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-8761a4dfcad4748ba11b1f4d8b52ff1c9518bd98228d26dc6debd292936096863</citedby><cites>FETCH-LOGICAL-c541t-8761a4dfcad4748ba11b1f4d8b52ff1c9518bd98228d26dc6debd292936096863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-015-4414-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-015-4414-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25676843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Joo, Min Wook</creatorcontrib><creatorcontrib>Shin, Seung Han</creatorcontrib><creatorcontrib>Kang, Yong-Koo</creatorcontrib><creatorcontrib>Kawai, Akira</creatorcontrib><creatorcontrib>Kim, Han Soo</creatorcontrib><creatorcontrib>Asavamongkolkul, Apichat</creatorcontrib><creatorcontrib>Jeon, Dae-Geun</creatorcontrib><creatorcontrib>Kim, Jae Do</creatorcontrib><creatorcontrib>Niu, Xiaohui</creatorcontrib><creatorcontrib>Tsuchiya, Hiroyuki</creatorcontrib><creatorcontrib>Puri, Ajay</creatorcontrib><creatorcontrib>Wang, Edward H. M.</creatorcontrib><creatorcontrib>Chung, So Hak</creatorcontrib><creatorcontrib>Chung, Yang-Guk</creatorcontrib><title>Osteosarcoma in Asian Populations Over the Age of 40 Years: A Multicenter Study</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Elderly patients with osteosarcoma (OSA) are no longer uncommon; however, many questions remain regarding this population. We investigated the clinicopathological characteristics and prognostic factors of OSA in an Asian population over the age of 40 years.
Methods
This was a multi-national, multi-institutional study by the Eastern Asian Musculoskeletal Oncology Group (EAMOG).
Results
A total of 232 patients were enrolled (116 males and 116 females), with a median age of 50 years at diagnosis; 25 (10.8 %) patients exhibited initial metastasis. Median follow-up was 52 months for survivors. We observed 102 osteolytic and mixed radiographic findings for 173 lesions. Histological subtypes other than osteoblastic type were frequent. Radiation-associated OSA was seen in seven patients, with a 5-year overall survival (OS) of 16.7 %. No Paget’s OSA was observed. High-grade spinopelvic OSA was seen in 29 (12.5 %) patients. The 5-year OS was 59.4 % in patients without initial metastasis and 45.2 % in patients with spinopelvic OSA. While surgery and initial metastasis were common prognostic factors for OS, chemotherapy was not. Histologic response to neoadjuvant chemotherapy was poor in 61 of 83 patients.
Conclusion
This study revealed distinct clinicopathological features of OSA patients over 40 years of age compared with younger patients, such as the high incidence of axial tumors, common osteolytic and mixed radiographic findings, the high frequency of unusual histologic subtypes, and poor prognosis. Contrary to Western elderly patients with OSA, there was no Paget’s OSA in this study, which may result in a lower incidence of secondary OSA. Prognostic factor analyses demonstrated chemotherapy did not influence OS.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Asian Continental Ancestry Group</subject><subject>Bone and Bones</subject><subject>Bone and Soft Tissue Sarcomas</subject><subject>Bone Neoplasms - drug therapy</subject><subject>Bone Neoplasms - pathology</subject><subject>Bone Neoplasms - surgery</subject><subject>Chemotherapy, Adjuvant</subject><subject>Female</subject><subject>Femur</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoadjuvant Therapy</subject><subject>Neoplasm Grading</subject><subject>Neoplasms, Radiation-Induced - drug therapy</subject><subject>Neoplasms, Radiation-Induced - pathology</subject><subject>Neoplasms, Radiation-Induced - surgery</subject><subject>Oncology</subject><subject>Osteosarcoma - drug therapy</subject><subject>Osteosarcoma - secondary</subject><subject>Osteosarcoma - surgery</subject><subject>Pelvic Bones</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Sacrum</subject><subject>Spinal Neoplasms - drug therapy</subject><subject>Spinal Neoplasms - pathology</subject><subject>Spinal Neoplasms - surgery</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><subject>Tibia</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkU1LxDAQhoMorl8_wIsEvHipZvLV1Nuy-AXKCurBU0ibdK10mzVphf33ZlkVEcRThswz7zA8CB0COQXKxVkEwhnPCIiMc-CZ3EA7INIPlwo2U02kygoqxQjtxvhKCOSMiG00okLmUnG2g6bT2DsfTaj83OCmw-PYmA7f-8XQmr7xXcTTdxdw_-LweOawrzEn-NmZEM_xGN8Nbd9UrusT8tAPdrmPtmrTRnfw-e6hp8uLx8l1dju9upmMb7NKcOgzlUsw3NaVsTznqjQAJdTcqlLQuoaqEKBKWyhKlaXSVtK60tKCFkySQirJ9tDJOncR_NvgYq_nTaxc25rO-SFqUCxnwKWA_9EcQHCZM5bQ41_oqx9Clw5JgVSBzFWx2g1rqgo-xuBqvQjN3ISlBqJXYvRajE5i9EqMXs0cfSYP5dzZ74kvEwmgayCmVjdz4cfqP1M_ALE6lY0</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Joo, Min Wook</creator><creator>Shin, Seung Han</creator><creator>Kang, Yong-Koo</creator><creator>Kawai, Akira</creator><creator>Kim, Han Soo</creator><creator>Asavamongkolkul, Apichat</creator><creator>Jeon, Dae-Geun</creator><creator>Kim, Jae Do</creator><creator>Niu, Xiaohui</creator><creator>Tsuchiya, Hiroyuki</creator><creator>Puri, Ajay</creator><creator>Wang, Edward H. M.</creator><creator>Chung, So Hak</creator><creator>Chung, Yang-Guk</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>20151001</creationdate><title>Osteosarcoma in Asian Populations Over the Age of 40 Years: A Multicenter Study</title><author>Joo, Min Wook ; Shin, Seung Han ; Kang, Yong-Koo ; Kawai, Akira ; Kim, Han Soo ; Asavamongkolkul, Apichat ; Jeon, Dae-Geun ; Kim, Jae Do ; Niu, Xiaohui ; Tsuchiya, Hiroyuki ; Puri, Ajay ; Wang, Edward H. M. ; Chung, So Hak ; Chung, Yang-Guk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-8761a4dfcad4748ba11b1f4d8b52ff1c9518bd98228d26dc6debd292936096863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Asian Continental Ancestry Group</topic><topic>Bone and Bones</topic><topic>Bone and Soft Tissue Sarcomas</topic><topic>Bone Neoplasms - drug therapy</topic><topic>Bone Neoplasms - pathology</topic><topic>Bone Neoplasms - surgery</topic><topic>Chemotherapy, Adjuvant</topic><topic>Female</topic><topic>Femur</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoadjuvant Therapy</topic><topic>Neoplasm Grading</topic><topic>Neoplasms, Radiation-Induced - drug therapy</topic><topic>Neoplasms, Radiation-Induced - pathology</topic><topic>Neoplasms, Radiation-Induced - surgery</topic><topic>Oncology</topic><topic>Osteosarcoma - drug therapy</topic><topic>Osteosarcoma - secondary</topic><topic>Osteosarcoma - surgery</topic><topic>Pelvic Bones</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Sacrum</topic><topic>Spinal Neoplasms - drug therapy</topic><topic>Spinal Neoplasms - pathology</topic><topic>Spinal Neoplasms - surgery</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><topic>Tibia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Joo, Min Wook</creatorcontrib><creatorcontrib>Shin, Seung Han</creatorcontrib><creatorcontrib>Kang, Yong-Koo</creatorcontrib><creatorcontrib>Kawai, Akira</creatorcontrib><creatorcontrib>Kim, Han Soo</creatorcontrib><creatorcontrib>Asavamongkolkul, Apichat</creatorcontrib><creatorcontrib>Jeon, Dae-Geun</creatorcontrib><creatorcontrib>Kim, Jae Do</creatorcontrib><creatorcontrib>Niu, Xiaohui</creatorcontrib><creatorcontrib>Tsuchiya, Hiroyuki</creatorcontrib><creatorcontrib>Puri, Ajay</creatorcontrib><creatorcontrib>Wang, Edward H. M.</creatorcontrib><creatorcontrib>Chung, So Hak</creatorcontrib><creatorcontrib>Chung, Yang-Guk</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Joo, Min Wook</au><au>Shin, Seung Han</au><au>Kang, Yong-Koo</au><au>Kawai, Akira</au><au>Kim, Han Soo</au><au>Asavamongkolkul, Apichat</au><au>Jeon, Dae-Geun</au><au>Kim, Jae Do</au><au>Niu, Xiaohui</au><au>Tsuchiya, Hiroyuki</au><au>Puri, Ajay</au><au>Wang, Edward H. M.</au><au>Chung, So Hak</au><au>Chung, Yang-Guk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osteosarcoma in Asian Populations Over the Age of 40 Years: A Multicenter Study</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>22</volume><issue>11</issue><spage>3557</spage><epage>3564</epage><pages>3557-3564</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
Elderly patients with osteosarcoma (OSA) are no longer uncommon; however, many questions remain regarding this population. We investigated the clinicopathological characteristics and prognostic factors of OSA in an Asian population over the age of 40 years.
Methods
This was a multi-national, multi-institutional study by the Eastern Asian Musculoskeletal Oncology Group (EAMOG).
Results
A total of 232 patients were enrolled (116 males and 116 females), with a median age of 50 years at diagnosis; 25 (10.8 %) patients exhibited initial metastasis. Median follow-up was 52 months for survivors. We observed 102 osteolytic and mixed radiographic findings for 173 lesions. Histological subtypes other than osteoblastic type were frequent. Radiation-associated OSA was seen in seven patients, with a 5-year overall survival (OS) of 16.7 %. No Paget’s OSA was observed. High-grade spinopelvic OSA was seen in 29 (12.5 %) patients. The 5-year OS was 59.4 % in patients without initial metastasis and 45.2 % in patients with spinopelvic OSA. While surgery and initial metastasis were common prognostic factors for OS, chemotherapy was not. Histologic response to neoadjuvant chemotherapy was poor in 61 of 83 patients.
Conclusion
This study revealed distinct clinicopathological features of OSA patients over 40 years of age compared with younger patients, such as the high incidence of axial tumors, common osteolytic and mixed radiographic findings, the high frequency of unusual histologic subtypes, and poor prognosis. Contrary to Western elderly patients with OSA, there was no Paget’s OSA in this study, which may result in a lower incidence of secondary OSA. Prognostic factor analyses demonstrated chemotherapy did not influence OS.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>25676843</pmid><doi>10.1245/s10434-015-4414-6</doi><tpages>8</tpages></addata></record> |
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| ispartof | Annals of surgical oncology, 2015-10, Vol.22 (11), p.3557-3564 |
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| subjects | Adult Age Factors Aged Aged, 80 and over Antineoplastic Agents - therapeutic use Asian Continental Ancestry Group Bone and Bones Bone and Soft Tissue Sarcomas Bone Neoplasms - drug therapy Bone Neoplasms - pathology Bone Neoplasms - surgery Chemotherapy, Adjuvant Female Femur Follow-Up Studies Humans Male Medicine Medicine & Public Health Middle Aged Neoadjuvant Therapy Neoplasm Grading Neoplasms, Radiation-Induced - drug therapy Neoplasms, Radiation-Induced - pathology Neoplasms, Radiation-Induced - surgery Oncology Osteosarcoma - drug therapy Osteosarcoma - secondary Osteosarcoma - surgery Pelvic Bones Prognosis Retrospective Studies Sacrum Spinal Neoplasms - drug therapy Spinal Neoplasms - pathology Spinal Neoplasms - surgery Surgery Surgical Oncology Survival Rate Tibia |
| title | Osteosarcoma in Asian Populations Over the Age of 40 Years: A Multicenter Study |
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