Abstract 3777: TAS4464, a novel and highly potent NEDD8 activating enzyme (NAE) inhibitor, causes apoptosis of sarcomas via cell cycle dysregulation

Background Soft-tissue sarcomas (STSs) are heterogeneous tumors that comprise approximately 1% of adult cancers. Patients with advanced STS have a poor prognosis because few chemotherapy options are available. NAE catalyzes the first step in the NEDD8 conjugation (neddylation) pathway. Because it ac...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2016-07, Vol.76 (14_Supplement), p.3777-3777
Hauptverfasser:	Fujita, Hidenori, Fujioka, Yayoi, Ishida, Keiji, Yoshimura, Chihoko, Hashimoto, Akihiro, Tsuji, Shingo, Mizutani, Takashi, Okubo, Shuichi, Matsuo, Kenichi, Utsugi, Teruhiro, Iwasawa, Yoshikazu
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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