Comparative study on endoscopic mucosal resection and endoscopic submucosal dissection for the treatment of elevated colorectal lesions

Objective To evaluate the efficacy and safety of endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) for the treatment of elevated colorectal lesions and analyze the risk factors for the local recurrence after EMR in order to improve the indications of EMR and ESD treatments. Methods The clinical and surgical data of 427 patients (with 606 colorectal lesions) undergoing EMR and 70 patients (with 80 colorectal lesions) undergoing ESD were retrospectively summarized. The clinical and surgical data of 145 patients undergoing EMR and 30 patients undergoing ESD obtained from follow-up visits were analyzed. The complications and local recurrence rates of two groups were compared and the risk factors for the local recurrence in the EMR group were analyzed. Results The rates of surgical complications in the ESD group and the EMR group were 7.14% (5/70) and 2.58% (11/427), respectively. There was no statistical difference in the rate of complications such as perforation and massive hemorrhage