Antioxidant properties of thio-caffeine derivatives: Identification of the newly synthesized 8-[(pyrrolidin-1-ylcarbonothioyl)sulfanyl]caffeine as antioxidant and highly potent cytoprotective agent

C8-substitution of caffeine molecule by (pyrrolidin-1-yl)carbothioylsulfanyl group results in tremendous increase of antioxidant and cytoprotective in vitro activity of this novel, highly functionalized compound. [Display omitted] A series of nine thio-caffeine analogues were synthesized and charact...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2016-08, Vol.26 (16), p.3994-3998
Hauptverfasser:	Jasiewicz, Beata, Sierakowska, Arleta, Wandyszewska, Natalia, Warżajtis, Beata, Rychlewska, Urszula, Wawrzyniak, Rafał, Mrówczyńska, Lucyna
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidant activity Antioxidants - chemical synthesis Antioxidants - chemistry Antioxidants - pharmacology Caffeine - chemical synthesis Caffeine - chemistry Caffeine - pharmacology Caffeine thioderivatives Crystallography, X-Ray Erythrocytes - cytology Erythrocytes - drug effects Erythrocytes - metabolism Haemolysis Hemolysis - drug effects Human erythrocytes Humans Magnetic Resonance Spectroscopy Mass Spectrometry Molecular Conformation Protective Agents - chemical synthesis Protective Agents - chemistry Protective Agents - pharmacology Spectroscopy, Fourier Transform Infrared Sulfhydryl Compounds - chemistry Trolox X-ray structure
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