Effects of grape seed extract supplementation on exercise-induced oxidative stress in rats
The aim of the present study was to investigate the effects of grape seed extract (GSE) supplementation on exercise performance and oxidative stress in acutely and chronically exercised rats. A total of sixty-four male rats were used in the study. Rats were divided into six groups: control, chronic...
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| Veröffentlicht in: | British journal of nutrition 2012-07, Vol.108 (2), p.249-256 |
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| description | The aim of the present study was to investigate the effects of grape seed extract (GSE) supplementation on exercise performance and oxidative stress in acutely and chronically exercised rats. A total of sixty-four male rats were used in the study. Rats were divided into six groups: control, chronic exercise control, acute exercise control (AEC), GSE-supplemented control, GSE-supplemented chronic exercise and GSE-supplemented acute exercise groups. Chronic exercise consisted of treadmill running at 25 m/min, 45 min/d, 5 d a week for 6 weeks. Rats in the acute exercise groups were run on the treadmill at 30 m/min until exhaustion. GSE were given at 100 mg/kg of body weight with drinking water for 6 weeks. Plasma was separated from blood samples for the analysis of oxidative stress markers. There was no significant difference in time of exhaustion between the acute exercise groups. Plasma malondialdehyde (MDA) levels were higher in the acute exercise groups and lower in the chronic exercise groups. GSE supplementation decreased MDA levels. Xanthine oxidase and adenosine deaminase activities were higher in the AEC group compared to all the other groups. NO levels were increased with both chronic exercise and GSE supplementation. Superoxide dismutase and glutathione peroxidase activities were lower in the acute exercised groups and higher in the chronic exercised groups. GSE supplementation caused an increase in antioxidant enzyme activities. In conclusion, GSE supplementation prevents exercise-induced oxidative stress by preventing lipid peroxidation and increasing antioxidant enzyme activities. |
| doi_str_mv | 10.1017/S0007114511005496 |
| format | Article |
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A total of sixty-four male rats were used in the study. Rats were divided into six groups: control, chronic exercise control, acute exercise control (AEC), GSE-supplemented control, GSE-supplemented chronic exercise and GSE-supplemented acute exercise groups. Chronic exercise consisted of treadmill running at 25 m/min, 45 min/d, 5 d a week for 6 weeks. Rats in the acute exercise groups were run on the treadmill at 30 m/min until exhaustion. GSE were given at 100 mg/kg of body weight with drinking water for 6 weeks. Plasma was separated from blood samples for the analysis of oxidative stress markers. There was no significant difference in time of exhaustion between the acute exercise groups. Plasma malondialdehyde (MDA) levels were higher in the acute exercise groups and lower in the chronic exercise groups. GSE supplementation decreased MDA levels. Xanthine oxidase and adenosine deaminase activities were higher in the AEC group compared to all the other groups. NO levels were increased with both chronic exercise and GSE supplementation. Superoxide dismutase and glutathione peroxidase activities were lower in the acute exercised groups and higher in the chronic exercised groups. GSE supplementation caused an increase in antioxidant enzyme activities. In conclusion, GSE supplementation prevents exercise-induced oxidative stress by preventing lipid peroxidation and increasing antioxidant enzyme activities.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114511005496</identifier><identifier>PMID: 22011589</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge: Cambridge University Press</publisher><subject>Adenosine Deaminase - blood ; Animals ; Antioxidants ; Antioxidants - therapeutic use ; Biological and medical sciences ; Biomarkers - blood ; Body weight ; Dietary Supplements ; Drinking water ; Enzymatic activity ; Enzymes ; Exercise ; Fatigue - blood ; Fatigue - enzymology ; Fatigue - prevention & control ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Grape Seed Extract - therapeutic use ; Lipid Peroxidation ; Male ; Malondialdehyde - blood ; Membrane Proteins - blood ; Motor Activity ; Nitric Oxide - blood ; Nutrition research ; Oxidative Stress ; Oxidoreductases - blood ; Performance-Enhancing Substances - therapeutic use ; Peroxidation ; Physical Conditioning, Animal - adverse effects ; Proanthocyanidins - therapeutic use ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Rodents ; Running ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>British journal of nutrition, 2012-07, Vol.108 (2), p.249-256</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright © The Authors 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-a11f8d737a50261710ab6252e0fab617a34165585e4b0ac55f8af8b2d97cd23</citedby><cites>FETCH-LOGICAL-c435t-a11f8d737a50261710ab6252e0fab617a34165585e4b0ac55f8af8b2d97cd23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26161424$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22011589$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BELVIRANLI, Muaz</creatorcontrib><creatorcontrib>GÖKBEL, Hakki</creatorcontrib><creatorcontrib>OKUDAN, Nilsel</creatorcontrib><creatorcontrib>BASARALI, Kemal</creatorcontrib><title>Effects of grape seed extract supplementation on exercise-induced oxidative stress in rats</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>The aim of the present study was to investigate the effects of grape seed extract (GSE) supplementation on exercise performance and oxidative stress in acutely and chronically exercised rats. A total of sixty-four male rats were used in the study. Rats were divided into six groups: control, chronic exercise control, acute exercise control (AEC), GSE-supplemented control, GSE-supplemented chronic exercise and GSE-supplemented acute exercise groups. Chronic exercise consisted of treadmill running at 25 m/min, 45 min/d, 5 d a week for 6 weeks. Rats in the acute exercise groups were run on the treadmill at 30 m/min until exhaustion. GSE were given at 100 mg/kg of body weight with drinking water for 6 weeks. Plasma was separated from blood samples for the analysis of oxidative stress markers. There was no significant difference in time of exhaustion between the acute exercise groups. Plasma malondialdehyde (MDA) levels were higher in the acute exercise groups and lower in the chronic exercise groups. GSE supplementation decreased MDA levels. Xanthine oxidase and adenosine deaminase activities were higher in the AEC group compared to all the other groups. NO levels were increased with both chronic exercise and GSE supplementation. Superoxide dismutase and glutathione peroxidase activities were lower in the acute exercised groups and higher in the chronic exercised groups. GSE supplementation caused an increase in antioxidant enzyme activities. In conclusion, GSE supplementation prevents exercise-induced oxidative stress by preventing lipid peroxidation and increasing antioxidant enzyme activities.</description><subject>Adenosine Deaminase - blood</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Body weight</subject><subject>Dietary Supplements</subject><subject>Drinking water</subject><subject>Enzymatic activity</subject><subject>Enzymes</subject><subject>Exercise</subject><subject>Fatigue - blood</subject><subject>Fatigue - enzymology</subject><subject>Fatigue - prevention & control</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Grape Seed Extract - therapeutic use</subject><subject>Lipid Peroxidation</subject><subject>Male</subject><subject>Malondialdehyde - blood</subject><subject>Membrane Proteins - blood</subject><subject>Motor Activity</subject><subject>Nitric Oxide - blood</subject><subject>Nutrition research</subject><subject>Oxidative Stress</subject><subject>Oxidoreductases - blood</subject><subject>Performance-Enhancing Substances - therapeutic use</subject><subject>Peroxidation</subject><subject>Physical Conditioning, Animal - adverse effects</subject><subject>Proanthocyanidins - therapeutic use</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Running</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkUtLxDAUhYMoOj5-gBspiOCmmpvm1aXI-ADBha7clEx6I5VOW5NUxn9viqOCLoRAEs53ziU5hBwCPQMK6vyBUqoAuACgVPBSbpAZcCVyJiXbJLNJzid9h-yG8JKuGmi5TXYYowBClzPyNHcObQxZ77JnbwbMAmKd4Sp6Y2MWxmFocYldNLHpuywtXKG3TcC86erRJrZfNXVS35I1egwha7rMmxj2yZYzbcCD9b5HHq7mj5c3-d399e3lxV1ueSFibgCcrlWhjKBMggJqFpIJhtSlAyhTcJBCaIF8QY0Vwmnj9ILVpbI1K_bI6Wfq4PvXEUOslk2w2Lamw34MFehCFbRkQv2PpvlSSwUioce_0Jd-9F16xkRxTUtBp0D4pKzvQ_DoqsE3S-PfE1RNDVV_Gkqeo3XyuFhi_e34qiQBJ2vABGta502XvvuHkyCBM158AK36luo</recordid><startdate>20120728</startdate><enddate>20120728</enddate><creator>BELVIRANLI, Muaz</creator><creator>GÖKBEL, Hakki</creator><creator>OKUDAN, Nilsel</creator><creator>BASARALI, Kemal</creator><general>Cambridge University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7TS</scope></search><sort><creationdate>20120728</creationdate><title>Effects of grape seed extract supplementation on exercise-induced oxidative stress in rats</title><author>BELVIRANLI, Muaz ; GÖKBEL, Hakki ; OKUDAN, Nilsel ; BASARALI, Kemal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-a11f8d737a50261710ab6252e0fab617a34165585e4b0ac55f8af8b2d97cd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adenosine Deaminase - blood</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Body weight</topic><topic>Dietary Supplements</topic><topic>Drinking water</topic><topic>Enzymatic activity</topic><topic>Enzymes</topic><topic>Exercise</topic><topic>Fatigue - blood</topic><topic>Fatigue - enzymology</topic><topic>Fatigue - prevention & control</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Grape Seed Extract - therapeutic use</topic><topic>Lipid Peroxidation</topic><topic>Male</topic><topic>Malondialdehyde - blood</topic><topic>Membrane Proteins - blood</topic><topic>Motor Activity</topic><topic>Nitric Oxide - blood</topic><topic>Nutrition research</topic><topic>Oxidative Stress</topic><topic>Oxidoreductases - blood</topic><topic>Performance-Enhancing Substances - therapeutic use</topic><topic>Peroxidation</topic><topic>Physical Conditioning, Animal - adverse effects</topic><topic>Proanthocyanidins - therapeutic use</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><topic>Running</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BELVIRANLI, Muaz</creatorcontrib><creatorcontrib>GÖKBEL, Hakki</creatorcontrib><creatorcontrib>OKUDAN, Nilsel</creatorcontrib><creatorcontrib>BASARALI, Kemal</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BELVIRANLI, Muaz</au><au>GÖKBEL, Hakki</au><au>OKUDAN, Nilsel</au><au>BASARALI, Kemal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of grape seed extract supplementation on exercise-induced oxidative stress in rats</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2012-07-28</date><risdate>2012</risdate><volume>108</volume><issue>2</issue><spage>249</spage><epage>256</epage><pages>249-256</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>The aim of the present study was to investigate the effects of grape seed extract (GSE) supplementation on exercise performance and oxidative stress in acutely and chronically exercised rats. A total of sixty-four male rats were used in the study. Rats were divided into six groups: control, chronic exercise control, acute exercise control (AEC), GSE-supplemented control, GSE-supplemented chronic exercise and GSE-supplemented acute exercise groups. Chronic exercise consisted of treadmill running at 25 m/min, 45 min/d, 5 d a week for 6 weeks. Rats in the acute exercise groups were run on the treadmill at 30 m/min until exhaustion. GSE were given at 100 mg/kg of body weight with drinking water for 6 weeks. Plasma was separated from blood samples for the analysis of oxidative stress markers. There was no significant difference in time of exhaustion between the acute exercise groups. Plasma malondialdehyde (MDA) levels were higher in the acute exercise groups and lower in the chronic exercise groups. GSE supplementation decreased MDA levels. Xanthine oxidase and adenosine deaminase activities were higher in the AEC group compared to all the other groups. NO levels were increased with both chronic exercise and GSE supplementation. Superoxide dismutase and glutathione peroxidase activities were lower in the acute exercised groups and higher in the chronic exercised groups. GSE supplementation caused an increase in antioxidant enzyme activities. In conclusion, GSE supplementation prevents exercise-induced oxidative stress by preventing lipid peroxidation and increasing antioxidant enzyme activities.</abstract><cop>Cambridge</cop><pub>Cambridge University Press</pub><pmid>22011589</pmid><doi>10.1017/S0007114511005496</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of nutrition, 2012-07, Vol.108 (2), p.249-256 |
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| subjects | Adenosine Deaminase - blood Animals Antioxidants Antioxidants - therapeutic use Biological and medical sciences Biomarkers - blood Body weight Dietary Supplements Drinking water Enzymatic activity Enzymes Exercise Fatigue - blood Fatigue - enzymology Fatigue - prevention & control Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Grape Seed Extract - therapeutic use Lipid Peroxidation Male Malondialdehyde - blood Membrane Proteins - blood Motor Activity Nitric Oxide - blood Nutrition research Oxidative Stress Oxidoreductases - blood Performance-Enhancing Substances - therapeutic use Peroxidation Physical Conditioning, Animal - adverse effects Proanthocyanidins - therapeutic use Random Allocation Rats Rats, Sprague-Dawley Rodents Running Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Effects of grape seed extract supplementation on exercise-induced oxidative stress in rats |
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