Dual acid-responsive supramolecular nanoparticles as new anticancer drug delivery systems

Considering the specific pH gradients of tumour microenvironments, a dual acid-responsive drug delivery system, which can respond to the tumor extracellular and intercellular pH stimuli, has been fabricated via simple host-guest recognition. Firstly, we synthesise 2,4,6-trimethoxybenzaldehyde modifi...

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Veröffentlicht in:	Biomaterials science 2016-01, Vol.4 (1), p.104-114
Hauptverfasser:	Wang, Chunran, Chen, Xiaofei, Yao, Xuemei, Chen, Li, Chen, Xuesi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Benzaldehydes - chemical synthesis Benzaldehydes - chemistry beta-Cyclodextrins - chemistry beta-Cyclodextrins - metabolism Cell Survival Cyclodextrins Doxorubicin - chemistry Doxorubicin - metabolism Drug Delivery Systems Drugs Humans Hydrogen-Ion Concentration Nanoparticles Nanoparticles - chemistry Polyethylene Glycols - chemical synthesis Polyethylene Glycols - chemistry Recognition Stimuli Tumors
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