Dual acid-responsive supramolecular nanoparticles as new anticancer drug delivery systems

Considering the specific pH gradients of tumour microenvironments, a dual acid-responsive drug delivery system, which can respond to the tumor extracellular and intercellular pH stimuli, has been fabricated via simple host-guest recognition. Firstly, we synthesise 2,4,6-trimethoxybenzaldehyde modifi...

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Veröffentlicht in:Biomaterials science 2016-01, Vol.4 (1), p.104-114
Hauptverfasser: Wang, Chunran, Chen, Xiaofei, Yao, Xuemei, Chen, Li, Chen, Xuesi
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container_end_page 114
container_issue 1
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container_title Biomaterials science
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creator Wang, Chunran
Chen, Xiaofei
Yao, Xuemei
Chen, Li
Chen, Xuesi
description Considering the specific pH gradients of tumour microenvironments, a dual acid-responsive drug delivery system, which can respond to the tumor extracellular and intercellular pH stimuli, has been fabricated via simple host-guest recognition. Firstly, we synthesise 2,4,6-trimethoxybenzaldehyde modified dextran (Dex-TMBA) and mPEG-imine-β-cyclodextrin (PIC), respectively. And then, through the host-guest recognition between the cyclodextrin (CD) of PIC and the benzene ring of Dex-TMBA, a kind of dual acid-responsive supramolecular drug delivery system can be fabricated. Under neutral pH conditions, anticancer drugs can be loaded by forming supramolecular nanoparticles via the host-guest recognition. While, at tumor extracellular pH (∼6.8), the acid-labile benzoic-imine of PIC cleaves and the nanoparticles are amino positively charged to facilitate cell internalization. Subsequently, due to the hydrolysis of acetal bonds in Dex-TMBA under significantly increased acidity in subcellular compartments such as the endosomes (∼5.3), the loaded doxorubicin releases from the endocytosed drug delivery. This dual acid-responsive nanoparticles can efficiently load and release drugs, acting as drug delivery systems for enhancing anticancer efficiency.
doi_str_mv 10.1039/c5bm00235d
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source MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Benzaldehydes - chemical synthesis
Benzaldehydes - chemistry
beta-Cyclodextrins - chemistry
beta-Cyclodextrins - metabolism
Cell Survival
Cyclodextrins
Doxorubicin - chemistry
Doxorubicin - metabolism
Drug Delivery Systems
Drugs
Humans
Hydrogen-Ion Concentration
Nanoparticles
Nanoparticles - chemistry
Polyethylene Glycols - chemical synthesis
Polyethylene Glycols - chemistry
Recognition
Stimuli
Tumors
title Dual acid-responsive supramolecular nanoparticles as new anticancer drug delivery systems
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