High Intratumoral Stromal Content Defines Reactive Breast Cancer as a Low-risk Breast Cancer Subtype

The current study evaluated associative effects of breast cancer cells with the tumor microenvironment and its influence on tumor behavior. Formalin-fixed, paraffin-embedded tissue and matched protein lysates were evaluated from two independent breast cancer patient datasets (TCGA and MD Anderson)....

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Veröffentlicht in:	Clinical cancer research 2016-10, Vol.22 (20), p.5068-5078
Hauptverfasser:	Dennison, Jennifer B, Shahmoradgoli, Maria, Liu, Wenbin, Ju, Zhenlin, Meric-Bernstam, Funda, Perou, Charles M, Sahin, Aysegul A, Welm, Alana, Oesterreich, Steffi, Sikora, Matthew J, Brown, Robert E, Mills, Gordon B
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - metabolism Breast Neoplasms - classification Breast Neoplasms - pathology Cadherins - metabolism Cell Line, Tumor DNA, Neoplasm - genetics Female Gene Expression Regulation, Neoplastic - genetics Humans MCF-7 Cells Middle Aged Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism RNA, Neoplasm - genetics Tumor Microenvironment - physiology
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