Long non-coding RNA HOTAIR promotes ischemic infarct induced by hypoxia through up-regulating the expression of NOX2

Mounting studies have illustrated an important role of HOTAIR in cancer progress, but few studies have reported its function in brain disease, including nerve cell-associated ischemic infarct. This study aimed to investigate the function of HOTAIR in ischemic infarct, involving its association with...

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Veröffentlicht in:	Biochemical and biophysical research communications 2016-10, Vol.479 (2), p.186-191
Hauptverfasser:	Yang, Lei, Lu, Zu-Neng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics Blotting, Western Brain Infarction - etiology Brain Infarction - genetics Brain Infarction - metabolism Cell Hypoxia Cell Line Gene Expression Regulation HOTAIR HT22 cells Hypoxia Hypoxia-Ischemia, Brain - complications Hypoxia-Ischemia, Brain - genetics Hypoxia-Ischemia, Brain - metabolism Ischemic infarct Membrane Glycoproteins - blood Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice, Inbred ICR NADPH Oxidase 2 NADPH Oxidases - blood NADPH Oxidases - genetics NADPH Oxidases - metabolism NOX2 Reverse Transcriptase Polymerase Chain Reaction RNA Interference RNA, Long Noncoding - genetics Up-Regulation
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