Ultrasound-Assisted Extraction of Pristimerin from Celastrus orbiculatus Using Response Surface Methodology
This paper describes the ultrasound-assisted extraction (UAE) of pristimerin from Celastrus orbiculatus. Methanol was the most effective for pristimerin extraction, followed by ethanol, ethyl acetate, n-butanol, and water. To optimize the conditions, the Box–Behnken design, a widely used form of res...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2016/01/01, Vol.39(1), pp.97-103 |
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| creator | Fang, Gong Li, Guocheng Pang, Chaohai Li, Wenxi Wang, Dingyong Liu, Chunxia |
| description | This paper describes the ultrasound-assisted extraction (UAE) of pristimerin from Celastrus orbiculatus. Methanol was the most effective for pristimerin extraction, followed by ethanol, ethyl acetate, n-butanol, and water. To optimize the conditions, the Box–Behnken design, a widely used form of response surface methodology, was used to investigate the effects of parameters on UAE. Several variables, such as extraction time, ultrasonic power, extraction temperature, and solvent-to-solid (S/S) ratio were investigated. The highest extraction yield of 1.843 mg/g was obtained using methanol under optimal conditions with an extraction time of 40 min, ultrasonic power of 105 W, an S/S ratio of 40 mL/g, and an extraction temperature of 52°C. The experimental values under optimal conditions agreed well with the predicted values, suggesting that UAE has good potential as an extraction method for pristimerin from C. orbiculatus. |
| doi_str_mv | 10.1248/bpb.b15-00664 |
| format | Article |
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Methanol was the most effective for pristimerin extraction, followed by ethanol, ethyl acetate, n-butanol, and water. To optimize the conditions, the Box–Behnken design, a widely used form of response surface methodology, was used to investigate the effects of parameters on UAE. Several variables, such as extraction time, ultrasonic power, extraction temperature, and solvent-to-solid (S/S) ratio were investigated. The highest extraction yield of 1.843 mg/g was obtained using methanol under optimal conditions with an extraction time of 40 min, ultrasonic power of 105 W, an S/S ratio of 40 mL/g, and an extraction temperature of 52°C. The experimental values under optimal conditions agreed well with the predicted values, suggesting that UAE has good potential as an extraction method for pristimerin from C. orbiculatus.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.b15-00664</identifier><identifier>PMID: 26466608</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Celastrus - chemistry ; Celastrus orbiculatus ; Molecular Structure ; optimization ; Plant Leaves - chemistry ; pristimerin ; response surface methodology ; Solvents ; Triterpenes - chemistry ; Ultrasonics - methods ; ultrasound-assisted extraction</subject><ispartof>Biological and Pharmaceutical Bulletin, 2016/01/01, Vol.39(1), pp.97-103</ispartof><rights>2016 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c735t-780f136ae2805f584013b8fe85bc28df34b9262c6da58380eadb7b3c31b434443</citedby><cites>FETCH-LOGICAL-c735t-780f136ae2805f584013b8fe85bc28df34b9262c6da58380eadb7b3c31b434443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26466608$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fang, Gong</creatorcontrib><creatorcontrib>Li, Guocheng</creatorcontrib><creatorcontrib>Pang, Chaohai</creatorcontrib><creatorcontrib>Li, Wenxi</creatorcontrib><creatorcontrib>Wang, Dingyong</creatorcontrib><creatorcontrib>Liu, Chunxia</creatorcontrib><creatorcontrib>aCollege of Pharmacy</creatorcontrib><creatorcontrib>bDepartment of Pharmacy</creatorcontrib><creatorcontrib>ZengCheng People's Hospital</creatorcontrib><creatorcontrib>Guangdong Pharmaceutical University</creatorcontrib><title>Ultrasound-Assisted Extraction of Pristimerin from Celastrus orbiculatus Using Response Surface Methodology</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>This paper describes the ultrasound-assisted extraction (UAE) of pristimerin from Celastrus orbiculatus. Methanol was the most effective for pristimerin extraction, followed by ethanol, ethyl acetate, n-butanol, and water. To optimize the conditions, the Box–Behnken design, a widely used form of response surface methodology, was used to investigate the effects of parameters on UAE. Several variables, such as extraction time, ultrasonic power, extraction temperature, and solvent-to-solid (S/S) ratio were investigated. The highest extraction yield of 1.843 mg/g was obtained using methanol under optimal conditions with an extraction time of 40 min, ultrasonic power of 105 W, an S/S ratio of 40 mL/g, and an extraction temperature of 52°C. The experimental values under optimal conditions agreed well with the predicted values, suggesting that UAE has good potential as an extraction method for pristimerin from C. orbiculatus.</description><subject>Celastrus - chemistry</subject><subject>Celastrus orbiculatus</subject><subject>Molecular Structure</subject><subject>optimization</subject><subject>Plant Leaves - chemistry</subject><subject>pristimerin</subject><subject>response surface methodology</subject><subject>Solvents</subject><subject>Triterpenes - chemistry</subject><subject>Ultrasonics - methods</subject><subject>ultrasound-assisted extraction</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1vEzEQxS0EoqFw5IpW4sJli7_tPVZRKUitQEDOlu31pg6OHWyv1P73OEkbJC5c7NHMT2-e_QB4i-AFwlR-NDtzYRDrIeScPgMLRKjoGUbsOVjAAcmeIybPwKtSNhBCATF5Cc4wp5xzKBfg1yrUrEua49hfluJLdWN3dd96tvoUuzR133Lr-q3LPnZTTttu6YIuNc-lS9l4OwddW70qPq67767sUiyu-zHnSVvX3bp6l8YU0vrhNXgx6VDcm8f7HKw-Xf1cfu5vvl5_WV7e9FYQVnsh4YQI1w5LyCYmKUTEyMlJZiyW40SoGTDHlo-aSSKh06MRhliCDCWUUnIOPhx1dzn9nl2pauuLdSHo6NJcFJJEEEgZJ_9HBdtLYiYa-v4fdJPmHNtDDhRpRuWe6o-UzamU7Ca1y36r84NCUO0DUy0w1QJTh8Aa_-5RdTZbN57op4QacH0E2tRbHVIMPrq_u20RxrfvVRgi3kTJAJGCCLdyEK2ABLOBSDE0peVRaVOqXrvTKp2rt8EdjJFBof1xMnia2judlYvkD-JEwAY</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Fang, Gong</creator><creator>Li, Guocheng</creator><creator>Pang, Chaohai</creator><creator>Li, Wenxi</creator><creator>Wang, Dingyong</creator><creator>Liu, Chunxia</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>20160101</creationdate><title>Ultrasound-Assisted Extraction of Pristimerin from Celastrus orbiculatus Using Response Surface Methodology</title><author>Fang, Gong ; Li, Guocheng ; Pang, Chaohai ; Li, Wenxi ; Wang, Dingyong ; Liu, Chunxia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c735t-780f136ae2805f584013b8fe85bc28df34b9262c6da58380eadb7b3c31b434443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Celastrus - chemistry</topic><topic>Celastrus orbiculatus</topic><topic>Molecular Structure</topic><topic>optimization</topic><topic>Plant Leaves - chemistry</topic><topic>pristimerin</topic><topic>response surface methodology</topic><topic>Solvents</topic><topic>Triterpenes - chemistry</topic><topic>Ultrasonics - methods</topic><topic>ultrasound-assisted extraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fang, Gong</creatorcontrib><creatorcontrib>Li, Guocheng</creatorcontrib><creatorcontrib>Pang, Chaohai</creatorcontrib><creatorcontrib>Li, Wenxi</creatorcontrib><creatorcontrib>Wang, Dingyong</creatorcontrib><creatorcontrib>Liu, Chunxia</creatorcontrib><creatorcontrib>aCollege of Pharmacy</creatorcontrib><creatorcontrib>bDepartment of Pharmacy</creatorcontrib><creatorcontrib>ZengCheng People's Hospital</creatorcontrib><creatorcontrib>Guangdong Pharmaceutical University</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fang, Gong</au><au>Li, Guocheng</au><au>Pang, Chaohai</au><au>Li, Wenxi</au><au>Wang, Dingyong</au><au>Liu, Chunxia</au><aucorp>aCollege of Pharmacy</aucorp><aucorp>bDepartment of Pharmacy</aucorp><aucorp>ZengCheng People's Hospital</aucorp><aucorp>Guangdong Pharmaceutical University</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrasound-Assisted Extraction of Pristimerin from Celastrus orbiculatus Using Response Surface Methodology</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>39</volume><issue>1</issue><spage>97</spage><epage>103</epage><pages>97-103</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>This paper describes the ultrasound-assisted extraction (UAE) of pristimerin from Celastrus orbiculatus. Methanol was the most effective for pristimerin extraction, followed by ethanol, ethyl acetate, n-butanol, and water. To optimize the conditions, the Box–Behnken design, a widely used form of response surface methodology, was used to investigate the effects of parameters on UAE. Several variables, such as extraction time, ultrasonic power, extraction temperature, and solvent-to-solid (S/S) ratio were investigated. The highest extraction yield of 1.843 mg/g was obtained using methanol under optimal conditions with an extraction time of 40 min, ultrasonic power of 105 W, an S/S ratio of 40 mL/g, and an extraction temperature of 52°C. The experimental values under optimal conditions agreed well with the predicted values, suggesting that UAE has good potential as an extraction method for pristimerin from C. orbiculatus.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>26466608</pmid><doi>10.1248/bpb.b15-00664</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Celastrus - chemistry Celastrus orbiculatus Molecular Structure optimization Plant Leaves - chemistry pristimerin response surface methodology Solvents Triterpenes - chemistry Ultrasonics - methods ultrasound-assisted extraction |
| title | Ultrasound-Assisted Extraction of Pristimerin from Celastrus orbiculatus Using Response Surface Methodology |
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