Impact of CYP2C9 Polymorphism Found in the Chinese Population on the Metabolism of Propofol in Vitro

The microsomal CYP2C9 alleles involved in the biotransformation of propofol, a widely used anesthetic agent, were investigated in vitro. To examine the enzymatic activity of the CYP2C9 alleles, kinetic parameters for propofol 4-hydroxylation were determined in recombinant human P450s CYP2C9 microsom...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2015/04/01, Vol.38(4), pp.531-535
Hauptverfasser:	Lian, Qing-Quan, Pan, Pei-Pei, Li, Jun-Wei, Lin, Han, Hu, Guo-Xin, Zuo, Ming-Zhang, Cai, Jian-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles allelic variant Anesthetics - metabolism Animals Asian Continental Ancestry Group - genetics catalytic character Cell Line CYP2C9 Cytochrome P-450 CYP2C9 - genetics Cytochrome P-450 CYP2C9 - metabolism Humans Hydroxylation Insecta metabolism microsome Microsomes - metabolism Mutation Polymorphism, Genetic propofol Propofol - metabolism
Online-Zugang:	Volltext
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