Standardized cell sources and recommendations for good cell culture practices in genotoxicity testing

•Good cell culture practice is critical in in vitro genotoxicity testing.•This initiative made stocks of mammalian cell lines available worldwide.•Cell lines L5178Y TK+/− 3.7.2C, TK6, CHO-WBL and CHL/IU were deposited at cell banks.•Recommendations for handling and monitoring the cell lines are desc...

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Veröffentlicht in:	Mutation research 2016-10, Vol.809, p.1-15
Hauptverfasser:	Lorge, E., Moore, M.M., Clements, J., O’Donovan, M., Fellows, M.D., Honma, M., Kohara, A., Galloway, S., Armstrong, M.J., Thybaud, V., Gollapudi, B., Aardema, M.J., Tanir, J.Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	3.7.2C Animals Cell culture Cell Culture Techniques - standards Cell growth Cells Cells, Cultured CHL/IU CHO Cells CHO-WBL Cricetulus Cytotoxicity DNA Damage - drug effects Dose-Response Relationship, Drug Genetic testing Genotoxicity Humans L5178Y TK Lymphocytes - cytology Lymphocytes - drug effects Lymphocytes - metabolism Lymphoma - drug therapy Lymphoma - metabolism Lymphoma - pathology Mammals Mice Mutagenicity Tests - standards Mutagens - toxicity Reference Standards Spectral Karyotyping TK6 Tumor Suppressor Protein p53 - metabolism
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