Pharmacological rescue of hERG currents carried out by G604S and wide type hERG co-expression

Summary Mutations in human ether‐a‐go‐go‐related gene (hERG) can lead to type 2 long‐QT syndrome (LQT2). The authors previously identified the hERG mutation G604S results in a loss of function and obviously decreased current amplitude and impaired channel protein trafficking when co‐expressed with W...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 2016-09, Vol.43 (9), p.851-861
Hauptverfasser:	Huo, Jianhua, Zhang, Aifeng, Guo, Xueyan, Qiang, Hua, Liu, Ping, Bai, Ling, Ma, Aiqun
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Cresols - pharmacology Electrophysiological Phenomena - drug effects Electrophysiological Phenomena - genetics Ether-A-Go-Go Potassium Channels - genetics Ether-A-Go-Go Potassium Channels - metabolism G604S Gene Expression HEK293 Cells hERG mutation Humans Ion Channel Gating - drug effects Ion Channel Gating - genetics long QT syndrome Mutation patch-clamp Phenylurea Compounds - pharmacology Piperidines - pharmacology Pyridines - pharmacology Temperature
Online-Zugang:	Volltext
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