AhR-dependent 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in human neuronal cell line SHSY5Y

•TCDD induces toxicity in SHSY5Y human neuroblastoma cells.•TCDD toxicity in SHSY5Y neuroblastoma cells depends on dioxin concentration and time of incubation.•Transient transfection of a hairpin RNA for AhR protects against TCDD neurotoxicity. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a xenobio...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2016-09, Vol.56, p.55-63
Hauptverfasser:	Morales-Hernández, Antonio, Corrales-Redondo, María, Marcos-Merino, José M., González-Rico, Francisco J., Sánchez-Martín, Francisco J., Merino, Jaime M.
Format:	Artikel
Sprache:	eng
Schlagworte:	AhR Antioxidants - pharmacology Apoptosis - drug effects Caspase 3 - metabolism Cell Line, Tumor Cell Nucleus - drug effects Cell Survival - drug effects Dose-Response Relationship, Drug Human neuronal cell line SHSY5Y Humans Neuroblastoma - pathology Neurons - drug effects Neurotoxicity Neurotoxins - pharmacology Polychlorinated Dibenzodioxins - pharmacology Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Stilbenes - pharmacology TCDD Time Factors Transfection
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