An In Vivo Method to Identify microRNA Targets Not Predicted by Computation Algorithms: p21 Targeting by miR-92a in Cancer

microRNA (miRNA) dysregulation is involved in the development and progression of various human cancers, including hepatocellular carcinoma (HCC). However, how to identify the miRNAs targeting specific mRNA in cells is a significant challenge because of the interaction complexity and the limited know...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2015-07, Vol.75 (14), p.2875-2885
Hauptverfasser:	Su, Xiaoping, Wang, Huaming, Ge, Wei, Yang, Mingjin, Hou, Jin, Chen, Taoyong, Li, Nan, Cao, Xuetao
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - mortality Computational Biology - methods Computational Biology - standards Cyclin-Dependent Kinase Inhibitor p21 - genetics Gene Expression Regulation, Neoplastic Genetic Association Studies - methods Hep G2 Cells Humans Liver Neoplasms - genetics Liver Neoplasms - mortality Male Mice Mice, Nude MicroRNAs - genetics Neoplasms - genetics Neoplasms - therapy Tumor Cells, Cultured
Online-Zugang:	Volltext
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