Induced pluripotent stem cells in the inherited cardiomyopathies: From disease mechanisms to novel therapies

Abstract Inherited cardiomyopathies lead to diverse clinical outcomes including heart failure, arrhythmias, and sudden death. Mutations in over 100 genes have been implicated in the pathogenesis of genetic heart diseases, including the main inherited cardiomyopathies, such as hypertrophic, dilated,...

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Veröffentlicht in:	Trends in cardiovascular medicine 2016-11, Vol.26 (8), p.663-672
Hauptverfasser:	Ross, Samantha Barratt, Fraser, Stuart T, Semsarian, Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiomyopathies - genetics Cardiomyopathies - pathology Cardiomyopathies - physiopathology Cardiomyopathies - surgery Cardiomyopathy Cardiovascular Cell Differentiation Cell Lineage Cells, Cultured Clinical outcomes Disease DNA methylation Fibroblasts Gene expression Genetic Genetic disorders Genetic Predisposition to Disease Genetics Genomes Heredity Humans Induced pluripotent stem cell Induced Pluripotent Stem Cells - metabolism Induced Pluripotent Stem Cells - transplantation Inherited Mutation Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Myocytes, Cardiac - transplantation Patients Phenotype R&D Regeneration Research & development Stem Cell Transplantation - adverse effects Stem Cell Transplantation - methods Stem cells Studies Transplantation, Autologous
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