ERK1/2-induced phosphorylation of R-Ras GTPases stimulates their oncogenic potential

The Ras-related (R-Ras) isoforms TC21, R-Ras and M-Ras are members of the Ras superfamily of small GTPases. R-Ras family proteins are frequently overexpressed in human cancers, and expression of activated mutants of these GTPases is sufficient to induce cell transformation. Unlike Ras, few activatin...

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Veröffentlicht in:	Oncogene 2016-10, Vol.35 (43), p.5692-5698
Hauptverfasser:	Frémin, C, Guégan, J-P, Plutoni, C, Mahaffey, J, Philips, M R, Emery, G, Meloche, S
Format:	Artikel
Sprache:	eng
Schlagworte:	13/95 14/19 42/109 45/41 631/67/70 631/80/458 64/60 82/58 82/80 96/106 Amino Acid Sequence Apoptosis Cancer Cell adhesion Cell Biology Cell migration Cell Transformation, Neoplastic - metabolism Defective mutant Extracellular signal-regulated kinase Gene expression Genetic aspects GTPases Guanosine triphosphatases Human Genetics Humans Immunodeficiency Internal Medicine Intracellular Space Isoforms Kinases Localization Medicine Medicine & Public Health Membrane Proteins - chemistry Membrane Proteins - metabolism Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Monomeric GTP-Binding Proteins - chemistry Monomeric GTP-Binding Proteins - metabolism Mutation Oncogenes Oncology Phosphorylation Physiological aspects Protein Binding Protein Interaction Domains and Motifs Protein Kinase Inhibitors - pharmacology Protein Transport Proteins Serine short-communication
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