Astrocytes Regulate Angiogenesis Through the Jagged1-Mediated Notch1 Pathway After Status Epilepticus

Vascular disruptions including blood–brain barrier breakdown and pathologic angiogenesis contribute to the development of epilepsy in normal brains. The Notch signaling pathway is activated in response to seizure activity, and its activation promotes seizures, although its exact role in angiogenesis...

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Veröffentlicht in:	Molecular neurobiology 2016-11, Vol.53 (9), p.5893-5901
Hauptverfasser:	Zhai, Xuan, Liang, Ping, Li, Yingliang, Li, Lusheng, Zhou, Yudong, Wu, Xuanxuan, Deng, Jinmu, Jiang, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Astrocytes - metabolism Biomedical and Life Sciences Biomedicine Brain - metabolism Brain - pathology Cell Biology Coculture Techniques Endothelial Cells - metabolism Endothelium Epilepsy Gene Knockdown Techniques Jagged-1 Protein - metabolism Kainic Acid Male Mice, Inbred C57BL Neovascularization, Physiologic Neurobiology Neurology Neurosciences Receptor, Notch1 - metabolism Signal Transduction Status Epilepticus - metabolism
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